I would like to clarify a point regarding the discovery of lymphatic-like vessels in the brain. The preprint appears to hint towards positioning it as the first report of this finding. However, the first published study on this subject was by Chang et al.(Ref 1 below). The authors reported on the presence and characteristics (diameters, origin, length, depth and regulation by stress) of deep brain lymphatic vessels. Their work was subsequently followed by two other independent studies (Ref 2 and 3). All studies were reviewed in a review article in 2024 (https://www.sciopen.com/article/10.26599/SAB.2024.9060001?issn=2709-1325).
Therefore, the preprint would represent a fourth report—not the first—of this discovery. It is concerning that previous foundational work has been either overlooked or cited in a misleading manner.
References 1. Chang J, Guo B, Gao Y, Li W, Tong X, Feng Y, et al. Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress. Research (Washington, DC), 2023, 6:0120.
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Öz E. 'Game changer' method lets scientists peer into mice. Science (New York, NY), 2023, 380(6644):443.
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Liu X-G, Hua Q, Peng T-T, Chang K-X, Deng C-G, Zhang J-N, et al. Histomorphological analysis of perfusion parameters and CNS lymphatic vessels in mice: an experimental method study. NeuroReport, 2024, 35(3).