The methylation differences between clones may be addressed by using the iPSC protocol described in https://doi.org/10.1038/s41586-023-06424-7 to establish the patient iPSCs, perhaps?
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The methylation differences between clones may be addressed by using the iPSC protocol described in https://doi.org/10.1038/s41586-023-06424-7 to establish the patient iPSCs, perhaps?