Figure 2.1.72.1.7\PageIndex{7}: An origin of replication. The sequence specific DNA duplex is melted then the primase synthesizes RNA primers from which bidirectional DNA replication begins as the two replication forks head off in opposite directions. The leading and lagging strands are shown along with Okazaki fragments. Note the 5’ and 3’ orientation of all strands. (Original-Locke-CC:AN)

Bolzer et al, PLoS Biology 2005 CC)