Very interesting work for those of us studying this niche topic of viral encephalitis in DBR1-deficient patients. The mechanistic explanation that dsRNA lariat accumulation desensitizes dsRNA sensors provides complementary and, in some respects, deeper insight of how DBR1 deficiency compromises the host's antiviral defense - adding to previous work by many of the same authors, such as Zhang et al. (2018), Chan et al. (2024), and Ru et al. (2025) that have contributed a great deal to our understanding of this pathology. I've been looking forward to its peer-review and publication ever since I first read it in the summer of 2025.