The impact of samples outside of brain tissues, such as the immune cells mentioned above, emphasizes the impact Schizophrenia has on a person. This mental disorder affects much more than just the brain- while scientists do not have many clear studies on this, the understanding of how Schizophrenia functions would grow deeper from studying the function of epigenetics on other peripheral biospecimens within the body.

A correlation in higher suicide rates and increased hyper-methylation of serotonin receptors, another essential neurotransmitter, is not only extremely scary, but also does make sense because of serotonin's key functions as a communicator. Specifically, it is associated with mood correlation, learning and memory (see annotation above), and sleep. Going off of the data presented in above paragraphs, this evidence strengthens the claim that Schizophrenia is heavilly associated with memory and learning blockage.

GABA is a neurotransmitter that slows the activity of neurons; therefore, it is interesting that hyper-methylation occurs where GABA is synthesized. The receptor sites of neurotransmitters are essential to the cells' communication, and as discussed within lecture and lab, cell communication is essential to cell differentiation, and is a large part of epigenetics when comparing what genes are expressed and which ones are not.

The correlation with a memory BDNF gene being methylated and the expression of not even just Schizophrenia, but many other mental disorders in general, raises questions of just how important the ability to learn and maintain information is relevant to dangerous mental disorders. This also makes me question what other genes associated with memory, learning, and neuronal development could be impacting the development of diseases such as Schizophrenia.

There is much more sequencing and experimenting to be done to determine the overall impact of epigenetics on Schizophrenia. Nothing is set in stone, only observations of a vast number of genes has been collected. There is much more that can impact Schizophrenia then just the genes recognized, and that is extremely important to remember when doing research about the mental disease.

This is an example of how dark matter/non-coding genes do have longterm impact on organism function! It would be interesting to see the impact on the organism if these non-coding RNAs had other modifications done onto them, because they are not the only thing triggering Schizophrenia to develop, or even if only half of this noncoding RNA was not modified.

Hypermethylation prohibits transcription factors from binding with DNA- this means that Schizophrenia, regarding the specific genes being referenced, stems from the inhibition of the Central Dogma process.

This is interesting because from scouting on the web, most clinics and reliable resources have a tendency to fixate on environmental impacts that lead to Schizophrenia- that being said, one thing I would like to stress using this paper with our project is how both genetic and environmental impacts play a large role in Schizophrenia's development.