The plague began in central Kyrgystan and killed up to 25 million people in China in the 1330s and 1340s, about 15 years before it first arrived in Constantinople.
I always assumed the 'Black Plague' originated in Europe so I was surprised to see evidence that the plague began in Kyrgyzstan.
I always liked science so I researched that bit further and found that traces of the plague bacteria were discovered in the enamel of the deceased buried in Kyrgyzstan, the deceased who were said to have died of pestilence.