One of the complications is that stand-up comedy delivers its humor through stories, often experiences and observations based on real life.
I have seen very few comedians who tell jokes that have nothing to do with their personal experiences, or they take a common experience, such as John Mulaney talking about college donations and makes it personal, such as by explaining how he payed to college 120,000$ for an English degree that he didn't use and didn't do have the things his professor asked of him. he explains how he did a bunch of drugs and didn't drink water the whole time. he makes it personal but also vague enough that others can relate.