Considering the extraordinary nature of this claim, I expect extraordinary levels of validation. The patterns of many CRANAD-3 positive structures look suspiciously like myelin sheaths. The authors mention that CRANAD-3 "may exhibit some nonspecific affinity for myelin", but have not explicitly excluded this possibility. To be convinced, I would like to see a demonstration that CRANAD-3 does NOT colocalize with myelin basic protein (MBP) and phosphorylated neurofilament (i.e. to show that axons are not present within the "channels"). MAP2, used by the authors, is mainly in neuronal dendrites and cell bodies.