A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.
What do you think about the one dose versus two doses decision-making within the development pipeline?
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- Nov 2025
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This article was published on December 10, 2020, and updated on December 16, 2020, at NEJM.org.
Why do you think this population (healthcare workers) was chosen and what downstream problems did it create?
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Notes
1.What was different about the powering of the Oxford study compared to the Pfizer/BNT study?
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently.
Read the articles carefully and answer the questions at the end of the page. While reading, we would like you to think about the key differences between the Oxford trial with the comparable mRNA study.
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