Meaningful differences in ghrelin response that were indepen-dent of changes in actual nutrients have important implicationsgiven recent interest in exploring the physiological and pharma-cological use of gut peptides as a means to manage weight (Bayneset al., 2006; Zigman & Elmquist, 2006). We argue that, much likeplacebo effects, alterations in mindset—what one believes andexpects to be eating—have the potential to elicit a seeminglyinappropriate sense of satiation. This is an intriguing addition tothe growing literature supporting the mindset’s pervasive, yet oftenunexpected, influence on physiological states. Additional researchendeavoring to understand better how psychological factors influ-ence the biological impact of food is particularly warranted. Per-haps if we can begin to approach even the healthiest foods with amindset of indulgence, we will experience the physiological sat-isfaction of having had our cake and eaten it too.
conclusion of impact