- Jan 2021
We observed that for genes subject to XCI, a general increase in methylation on the Xi occurs at gene promoters. In comparison, genes escaping XCI show higher levels of methylation within gene bodies on both the Xa and Xi, but reduced promoter methylation only on the Xi.
They found that there were higher levels of DNA methylation in the promoters of genes that underwent XCI on the Xi. Escapee genes, by contrast, have less promoter methylation on Xiin their promoters o the Xi, but an increase in methylation within gene bodies.