We examined the above by using data from a study of effectson sleep architecture of the two aforementioned antidepres-sants in depressed outpatients

blockade of thepostsynaptic 5-HT2

nefazodone

ower delta sleep ratio (DSR)

the percentage of time spentin SWS over the whole of the night (% SWS) appear to bedecreased in depression compared with normal controls

low wave activity(SWA

Moreove

Overall, females

Globalsleep quality assessed seven indicators of sleep (dys)function: subjec-tive sleep quality, sleep latency, sleep duration, habitual sleep effi-ciency, sleep disturbances, use of sleep medication, and daytimedysfunction using the Pittsburg Sleep Quality Index

The “equi" part of the word relates to equal, as one might expect, but it does not relate to absolute concentra-tions. What happens when a biochemical reac-tion is at equilibrium is that the concentra-tions of reactants and products do not change over time.

subtle electronic ones, more significant covalent modifications, or structural changes arising from the flexibility inherent in enzymes, but not present in chemical catalysts. Flexibility allows movement and movement facilitates alteration of electronic environments necessary for catalysis. Enzymes are, thus, much more efficient than rigid chemical catalysts as a result of their abilities to facilitate the changes necessary to optimize the catalytic process.

activation energy

metabolic pathways