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  1. Jan 2025
    1. Walter Kempner is no I don't so he's an interesting fellow kind of a controversial guy from the 1940s and 1950s maybe the 1960s he's a physician who did a bunch of studies with diabetics people that were morbidly obese morbidly obese we're 00:11:59 talking hundreds of pound obesity if your team wants to find like images you can see the study so he has this thing called the rice diet and in the 1950s and 1960s he put people on a very very 00:12:12 high carb very lowfat very low protein diet it was essentially white sugar so sucrose and white rice was the majority of the 00:12:23 diet and they got better they lost I mean some people went from like literally being round to being thin their diabetes got better so he fixed 00:12:36 diabetes with a very high carb very low fat very low protein diet and it was by necessity it was low protein because it was all carbohydrates and the problem is that the human brain doesn't want to do this like so he's controversial because in 00:12:50 order to get his patients to do this he had to like he had to do some crazy things to cajo them and so I'm not condoning his experiments but the science is is interesting and what it says about human physiology to me is is 00:13:03 very compelling that you can give someone a diet of pure white sugar and rice and their diabetes gets better why does their diabetes get better and this is not even short term this is long term 00:13:15 so that in the span of I think it was four to six months he could then liberalize these people's diets and their diabetes did not return so this is really interesting to me and I think it kind of ties into the seed oil 00:13:27 piece and I'm not suggesting that this is a a reasonable therapy for people because what we know about human physiology and the human brain is that if you try to push any of the macros too far our brain really 00:13:39 Rebels humans seem to be able to lose weight by cutting carbohydrates or cutting fat if you cut both of them together you have what's called rabbit starvation and you can lose a lot of weight very quickly but it's very 00:13:52 stressful on the body hormonally if you cut carbohydrates you have a ketogenic diet if you cut fat you have a lowfat diet and if you look at the trials head-to-head of low fat or low carb they both have about the same amount of weight loss so there's some contention 00:14:05 but it doesn't really look like a ketogenic diet is magical for weight loss a like a lowfat diet is magical for weight loss relative to Kido they both work but when you cut both when you cut 00:14:17 the the fat really really low that's interesting to me and this is what happened in the rice diet and they the the fat was so low that these Pro people were probably becoming fatty acid deficient and there's a fatty acid that 00:14:30 you can measure in the human blood it's called me acid Mead and that's an indication of fatty acid deficiency essential quote unquote fatty acid deficiency and so the hypothesis is that one of the reasons this diet might have 00:14:43 worked is because when you restrict fat that much the cell has to turn over those cell membranes in a different way and that probably causes a lot of these polyunsaturated fats that are stuck in the cell membranes to become mobilized 00:14:56 and turn over the human body doesn't make polyunsaturated fats but if you feed someone carbohydrates the human body can make saturated fats and monounsaturated fats but this is essentially an accelerated way to get 00:15:10 rid of what were potentially excess polyunsaturated fatty acids in these people's cell membranes again I don't think this is a good therapy for humans because it's so hard on the brain humans don't want to do this we sort of 00:15:22 gravitate toward like a third fat third carbohydrates and maybe a third protein depending how you're looking at it maybe a little less if you're doing grams or calories but there's some balance of those things that kind of is what our body tends to if you go too low fat your 00:15:35 body will Rebel and you know if you go too low carb your body's like I want some carbohydrates so the indication here is there's something going on in these cell membranes and there's a massive shift that happens in the cell membrane when you get very very low fat 00:15:47 and I think that's having to do with this turnover of these omega-6 fatty acids so there's a couple of ways to do this without going solo fat you can also just get them out of your diet like extremely intentionally and then do more 00:16:00 fats that are saturated in their place and so this is the part where it gets a little bit cumbersome for people to think about but I think that you can get similar results by just having a low linolic acid diet so let's back up for a 00:16:13 moment talk about linolic acid Omega 6 which means that six carbons from the end of the molecule is the first double bond it's an 18 carbon molecule it's polyunsaturated which means it has multiple double bonds and there's a 00:16:28 small amount in ruminant fat so things like cows or goats or bison or lamb sheep deer small amount one to 2% but animals like humans or pigs or 00:16:43 chickens that are monogastric accumulate linolic acid so the more of this fatty acid we eat the more we store we don't have a way to get rid of it like cows do cows can transform it so where do we 00:16:55 find linic acid in the human diet we find it in chicken and pigs that are fed corn and soy so evolutionarily inappropriate diets and you find it in nuts and seeds plant foods and we have a massive 00:17:08 input of this linolic acid into the human diet now because we're feeding our animals corn and soy things that they've never eaten historically and all of our processed food is combined is added with these 00:17:22 seed oils things like corn canola sunflower safflower soybean grape seed these are all seed oils and they contain between 25 and 65% linolic acid so what you have I 00:17:35 think is an evolutionarily inconsistent amount of linolic acid coming into the human diet and just like pigs just like chickens when we eat corn and soy when we eat Foods when we eat seed oils that 00:17:48 have a lot of this linolic acid we store it and I think that over time it accumulates in our cell membranes and in the membranes of our mitochondria these little powerhouses in the cell and causes problems and we can get into how it might cause problems at the cellular 00:18:00 level if you want but that's kind of the the 15,000 foot perspective that we have this this fatty acid that is in our food supply historically but when we are living in a quote naturalistic way in 00:18:13 the forest in the jungle there's really very limited access to foods that are high in this it's very hard to get the amount of seeds that would you would get even in 3 to five tablespoons of seed oils so I've done some content about 00:18:25 this you look at corn oil for instance or rice brand oil is an even better example Chipotle very very popular and I went to Chipotle and I asked what do you cook your food and they said rice brand oil so it's the oil extracted from the 00:18:39 brand of the rice okay they put three to five tablespoons of rice brand oil into a a bowl like a burrito bowl or a burrito with the rice and the beans and the the 00:18:50 meat that are cooking in there to get three to five tablespoons of rice brain oil you'd have to eat something like three to four pounds of rice so something that humans would never ever do right it's the same with 00:19:04 sunflower seeds sunflower seed oil is in almost everything soybean oil is very common corn oil to get 3 to 5 tablespoons of corn oil you have to eat somewhere between 60 and 75 ears of corn 00:19:17 so you can see here that we have now even if we were eating an occasional sunflower seed from a sunflower plant because we're starving as humans historically or we're eating a little bit of rice and getting the oil from the brand or we're EA eating some corn in 00:19:30 Native American population we're never going to get anywhere close to the amount of linolic acid coming into our bodies in 2023 and really this amount has been increasing massively over the last 100 to 110 years

      super interesting