And indeed that is the fittest and most proper hour wherein to write these high matters and deep sciences: as Homer knew very well, the paragon of all philologues,
In this quote, Rabelais is explaining that the best time to write is while one is eating and drinking, which Homer was well aware of. Homer was a Greek poet whose work inspired Rabelais. This can be seen the way his work is structured. All in all, it is safe to assume that Rabelais most likely wrote some of this work while under the influence of alcohol.
Ahn, Joyce. “The Renaissance Reception of Homer’s Odyssey: A Review-Essay.” SalemPress, 16 Sept. 2019, salempress.com/Media/SalemPress/samples/odyssey_pgs.pdf.