just like conc= mol/vol, mol/conc= vol; if mol= mol excreted, conc= total conc of substance in plasma, then vol= the vol of plasma that was cleared of this mol. excreted (not perfect, but it helps you remember it a bit better)

excreted = U x V

error: should be DECREASED

gfr represents the maximum filtration of general plasma of all the kindeys, at the glomerulus, ml per min.

filtered load multiplies GFR (divided if the susbtance isnt freely filtered) with plasma conc to give you the actual concentration of this substance being filtered per min.

doesnt affect your calculated clearance, since this amount bound will be corrected for by a drop in urin conc. only if you calculate something that isnt looking at excretion rate too (i.e. filtered load) do you need to alter your calc (by reducing GFR proportionately to show how much the actual filtration rate for this substance is)