Revise: Missing All Doses (N=275)

144/262 = 54%

Revise: Missing first order within 45 days (N=262)

Can you add a combined BTKi group column in this table? Since you matched on the BTKi group vs VenO, that will prob better show the matching variables are similar.

273 here but we should have 275 VenO patients.

Also, at the bottom of the table it says 13% had missing all dose info, but this point says 273 had 400 mg dose at some point in time.

Confirm that pts are exact matched in age category, gender and race. Seems the acalabrutinib arm is different than Ibr and VenO

rwTTD?

Table 1 has 300 Acala and 1777 Ibrutinib patients. Where did these patients come from?

Instead of "unknown", "Not calculated" with a footnote that 2L start not reported (or other).

This is outdated? Based on tab 3.3, this should be 48.0 mo for BTKi

can you please include the other clinical/demographic variables: payer, region, cytogenetics ? Also can you add the 2nd line therapies for the 2 groups?

surprised there are no ibrutinib patients in the "nibs group". Can you pls check this?

relabel to "No 2nd line therapy"

On 3.2, the p-values and # at risk are different from the last run. Also the HR.

Let's also revisit the # at risk from our last convo

should this be "Received any cytogenetic test"?

Should this be 268?

how do I interpret a negative number here?

Is the p-value of 0.0098 on the KM curve testing the TTNTD?

Can you confirm what was exact matched-- age category, gender and race? In an outdated slide, I had also noted that the model included practice type, payer category, SES although not exact matched

can you include unknown/missing in the percentage?