madness
This madness seems to stem from the inability to freely express themselves within a dominant culture that has essentially destroyed this generation. It has left them physically and mentally poor. They search for other "fixes" to fill the hole that has been left by the dominant culture and the authority which runs it. Their stance on politics, art, and life, in general, has left them as targets for the oppressors to destroy. Ginsberg makes it clear that this has been extremely taxing on them by constantly mentioning the life they lead.