multi-objective optimization (MOO) field
Heard of it before but can definitely use a refresher
15 Matching Annotations
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pdfs.semanticscholar.org pdfs.semanticscholar.org
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Consequently, additional modifications (e.g., cyclization, DAAs) are oftenrequired, making the screening process more time-consuming and the manufacturingprocess more costly and complex
Yeah, I remember this. takes so mych longer than you would intitially expect
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myloidogenic and aggregation-prone properties can also be ex-ploited as a functional antimicrobial mechanism
I had never heard of aggregation as something positive
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These architectures learn underlying statistical and functional patterns fromlarge peptide datasets, enabling them to explore vast sequence spaces that are inaccessibleto traditional empirical and rational design methods.
This is really interesting
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decision trees trained on bootstrapped subsets of the data,
I've seen it before
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Boman index
Have not heard of this one
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The pathogenesis of these infectionsis largely driven by microbial biofilm formation on implant surfaces, which confers markedtolerance to antimicrobial therapy and host immune responses, thereby hindering eradica-tion and frequently necessitating prolonged antimicrobial therapy and complex surgicalinterventions, including implant revision or removal
why are the implants so susceptible to this?
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quorum-sensing (QS) inhibitors
This is hella clever and interesting
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Artificial intelligence models evaluate peptide proper-ties, including charge, hydrophobicity, amino acid distribution, and secondary structure, to predictantimicrobial activity and toxicity.
It looks at databases of current animicrobials and see common trends in their overall charges, aa compositions and other properties
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antimicrobial coatings formedical devices
thats cool. yesssssss
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barrel-stave and toroidal poremodels
Definitely didn't know what these were!
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variational autoencoders
No idea what this is so i looked it up and this is what it means: A type of artificial neural network used as a generative model to compress data and create new, realistic samples based on probability distributions
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ESKAPE pathogens
Didn't know about C.auris that was new info to me
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Antimicrobial resistance (AMR)
Using AI to combat it is so cool!
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a mode of action that generally makes theemergence of resistance more difficult
why tho? why does it make emergence of resistance more difficult
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