what the HPA stands for

Side Note: FKBP5 gene is unlike the taster gene that we looked at where it is known to be for "tasting," rather this gene is "related to stress response" which goes to show that Schizophrenia is likely onset by traumatically stressful events.

If less methylated, this means that the DNA is more accessible for transcription, which would allow the gene to be expressed more. In this case, if these genes are what causes schizophrenia, less methylation is extremely bad for patients.

Perhaps these SNPs are silent based on when they are transcribed, meaning when the trauma happens depends on whether or not the SNP is in transcription and then reflected in translation?

How/Why would a specific allele have more of a significant risk for people of the twin population? Would it be because of how they are in-utero or possibly because of the split egg for identical twins?

What about carriers of the risk G allele without accounting for childhood trauma?

Important

Would higher mRNA levels indicate that there are too many of the transcription factors present in the body that make transcription happen too much?

If something like food deprivation increases FKBP5 gene expressions, which is hypothesized to make someone more susceptible to schizophrenia, this would presumably make people in lower income areas more prone to getting schizophrenia. Possibly why homeless people have a higher ratio of people with mental illness compared to people who have homes?

Even though cortisol may not be the cause of forms of psychosis or more particularly schizophrenia, it does correlate with how severe symptoms are which is very interesting. Maybe something else is the on/off switch for the disease, while cortisol acts as an amplifier?

Given that cortisol has a glucocorticoid receptor (GR), the receptor is likely membrane impermeable.

Since the GR acts as a transcription factor, transcription of certain DNA would be severely impacted of the transcription factor were not present because it would not be able to effectively carry out the function in an efficient manner.

Note: include the first part of this sentence too (I could not because of formatting for some reason)

This is extremely interesting because the body has its own signaling and response systems within the body that happen subconsciously such as releasing cortisol. Does this lead to signs that cortisol is in fact bad for us and causing mental diseases such as Schizophrenia? If so, would there even be a fix given that this is something that the body produces on its own?

Can you guys see my comment?

Pretty sure the inhibition of FKBF5 gene in schizophrenia is what causes the HPA axis dysregulation in patients that experience schizophrenia relative to the specific gene.

**Check with original review article **

connection to lecture about cell signaling and negative feedback inhibition of gene expression

How the HPA axis is operated