47 Matching Annotations
  1. Jun 2017
    1. receptor-mediated endocytosis begins

      Both West Nile Virus and Norovirus enter the cell through receptor-mediated endocytosis

    2. positive-sense single stranded RNA

      Both West Nile Virus and Norovirus have a genome structured as positive-sense single-stranded RNA

    1. Internalized

      Both West Nile Virus and Norovirus enter the cell through receptor-mediated endocytosis

    2. Positive-sense RNA strand ((+)RNA)

      Both West Nile Virus and Norovirus have a genome structured as positive-sense single-stranded RNA

  2. May 2017
    1. These proteases play a prominent role inthe pathogenesis of experimental pneumonia(Lyerly and Kreger, 1983) and keratitis (Lyerlyet al., 1981).

      virulence

    1. As control measures, the distributor improved hygiene measures, and the military bases thoroughly cleaned the bathrooms and kitchens, and increased awareness on hand hygiene among the soldiers. From Week 21, the kitchens in all three bases in Troms voluntarily elected to close the salad bar and refrain from serving pork products until the outbreak was resolved.

      public health interventions

    1. They have no specific growth requirements and grow well on standard laboratory media, but grow best between 35 and 37 °C and at pH 7.2.

      Growth requirements for Klebsiella genus

    1. A total of 5,093 isolates were collected in 2014. Of these, 25.3% were resistant to tetracycline, 19.2% to ciprofloxacin, and 16.2% to penicillin (plasmid-based, chromosomal, or both)

      additional antibiotic resistance numbers from one study by cdc

    1. n 2010, 27.2% of all GISP isolates were resistant to penicillin, tetracycline, ciprofloxacin, or some combination of those antimicrobials and 6.9% of isolates were resistant to all three antimicrobial

      antibiotic resistance numbers

    1. Disseminated infection is rare but can occur 1 to 3 percent of adults

      Disseminated infection

    2. ceftriaxone in a single 125-mg dose intramuscularly or ciprofloxacin (Cipro) in a single 500-mg dose orally,

      antibiotic treatment

    3. usually do not cause adverse sequelae

      Sequelae

    1. The oxidase test uses the tetramethyl derivative of the oxidase reagent

      oxidase test

    2. The catalase test (3% hydrogen peroxide) or superoxol (30% hydrogen peroxide) are other rapid tests used in the presumptive identification of N gonorrhoeae. A drop of the reagent is placed in the centre of a clean glass slide and the suspect colony is picked with a loop and emulsified in the reagent. N gonorrhoeae will produce a positive reaction with bubbling within 1 s to 2 s. Weak bubbling or bubbling after 3 s indicates a negative reaction (5) (Table ​(Table2).2).

      Catalase test

    3. The inoculated plates should be incubated at 35°C to 37°C in a moist atmosphere enriched with CO2 (3% to 7%) (5). An 18 h to 24 h culture should be used as the inoculum for additional tests. Plates should not be incubated for longer than 48 h because most old cultures would not survive storage conditions.

      Culture conditions

    4. intracellular Gram-negative kidney-shaped diplococci in polymorphonuclear leukocytes

      Gram stain morphology

  3. Apr 2017
    1. open – labeled studies

      A study in which both the researchers and the patient knows which drug the patient is given.

      https://en.wikipedia.org/wiki/Open-label_trial

    2. bacteriostatic

      Stops bacteria from reproducing, but does not necessarily kill them.

      https://en.wikipedia.org/wiki/Bacteriostatic_agent

    3. vancomycin exposure after colonization as the strongest predictor of prolonged colonization

      Allowed to grow better when there is less competition from vancomycin-susceptible bacteria?

    4. only a handful

      There are 3 different kinds of Vancomycin-resistant S. aureus that vary in how resistant they are.

      https://en.wikipedia.org/wiki/Vancomycin-resistant_Staphylococcus_aureus

    5. Neutropenia

      Fewer neutrophils in the blood

    6. APACHE scores

      Indicates severity of disease

    7. q6h

      Every 6 hours

    1. These events cause the symptoms of septic shock that occur during severe infections caused by S aureus.

      Toxicity

    2. S aureus cells express on their surface proteins that promote attachment to host proteins such as laminin and fibronectin that form part of the extracellular matrix

      Attachment

    3. The catalase test is important in distinguishing streptococci (catalase-negative) staphylococci which are catalase positive.

      Distinguish between staph/strep

    1. more likely to occur in children younger than 5 years and people with weakened immune systems.

      Does the friend have a weakened immune system?

    2. Later, the person's lymph nodes closest to the original scratch or bite can become swollen, tender, or painful.

      Do they have swollen areas/bumps, especially near a bite/scratch?

    3. About three to 14 days after the skin is broken, a mild infection can occur at the site of the scratch or bite.

      Did they recently have a skin infection where they may have gotten bitten/scratched?

    4. Cat-scratch disease (CSD) is a bacterial infection spread by cats.

      Have they been in physical contact (bitten, licked, etc.) with a cat?

    1. pigs are 'mixing vessels,'

      Pigs are susceptible to both avian and human flu viruses, making them especially effective mixing vessels

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702078/

    2. In less than four months, about 4,000 cases and 550 deaths from SARS could be traced to Liu's stay in Hong Kong.

      The CDC states that in the 2003 outbreak, there were a total of 8,098 cases of SARS, with 774 deaths. 8 of these cases were in the United States.

      https://www.cdc.gov/sars/about/fs-sars.html#outbreak

    3. no longer needs the animal reservoir