maller sample size.
What would be the ideal sample size for an experiemnt like this?
8 Matching Annotations
- Last 7 days
-
Local file Local file
-
-
n psychiatrically unaffectedcomparisons, we observed clear regional differences in geneexpression between the DLPFC and caudate, suggesting specia-lization for distinct functional roles in these two circuit contexts.
This is interesting. How do these two areas interact on a broader scale and what might be the reason for these differences?
-
CHODL-SST neuron density in the DLPFC and caudate inunaffected comparisons and schizophrenia
This lines up with the previous statment that there are no reductions in number of SSTs but the dysfunction was within genetic variation. What might density play a role in or indicate when presenting differences?
-
Thus,CHODL-SST neuron density differs markedly between regions, butis not altered by diagnosis in either region.
How can this conclusion shape future investigatory work in this area of investigating SST neurons and schizophrenia?
-
HODL-SSTneurons were enriched along the layer 6–white matter border inthe DLPFC (Fig. 1A) and were relatively homogeneously distrib-uted in the caudate (Fig. 1B)
What might behind the differences and simmilarities in distribution amoung these two regions?
-
fluorescence intensity per cell
Is there any factor that can impact flourescence intensity which might alter the results?
-
prior studies indicate that SST neurons also populate the deepest aspect oflayer 6
What is the significance of this distribution of the NADPH-diaphorase neurons being in the most superficial layer versus the SST neurons populating the deepest layer 6?
-
Labelingbatches were performed such that a single run included both the DLPFCand striatum tissue sections from a given individual, and pairs wereprocessed together.
Too what specificity were these regions labelled and was it in a level of detail at which the researchers would be able to get a wider picture of the DLPFC and striatal SST projections?
-