In the UKB cohort, we cannot exclude the possibility of a recallbias, as these participants completed retrospective questionnaires andlikely relied on information received, at some point, from their par-ents. We mitigated this by including only participants who providedconsistent answers regarding PEMCS between the initial assessmentand the neuroimaging visit.
Can the researchers really consider this mitigation when participants could just be consistently recalling misinformation?
daily consumption of at least one cigaretteevery day during the second gestational trimester was the definitionof PEMCS in this cohort; effectively, the exposed individuals wereexposed to smoking during the entire pregnancy
Do the results differ if the mother was smoking the same amount solely in the first trimester?
The knockout (KO) of the β 2 subunit of thenicotinic receptor in the mouse impairs this signaling and reducesretinal waves
If nicotine affects these receptors, could nicotine exposure change retinal waves and affect visual development in humans?