In entering on this field, the commissioners are aware that they have to encounter much difference of opinion as to the extent which it is expedient that this institution should occupy
I love that here they state they are aware of the "difference of opinion" they will have to encounter upon establishing this University. To me, this really embodies some of the democratic ideals Thomas Jefferson was all about. A society, and in this case an institution, needs differing opinions to help it to keep advancing.