- Last 7 days
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onco1.gitlab.io onco1.gitlab.ioAQIM21
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filter(dead != "3. not known")
are there anyone with a value like this ?
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progression free survival
Progression free survival seems to be missing ??
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after treatment due to the treatment related adverse effects.
It would be useful to describe the causes and times of death for these patients as these are considered treatment related. 8.5% treatment related death is a significant proportion.
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Overall survival of individual risk groups
In the plot above please indicate that time is in years .
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dose intensity modification
Dose intensity is not exactly the same as dose reduction. If the indicator asks for intensity then this should be clarified properly.
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chemo_10_dose_reduction
How was this variable entered ?
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6
The difference of 1 patient for what reason ?
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days
May be useful to report the maximum number of days. Also check the minimum number of days. Not clear as to what proportion have completed planned radiotherapy (may be 100%) - should be mentioned in the table.
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Unknown
Presumably these 3 patients did not start RT due to some reason here ?
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Front line treatment duration
Fornt line treatment duration is not calculated.
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132 (113, 153)
This is a very large gap and reasons for these need to be discussed including the protocol in place for starting chemotherapy.
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This will be applicable only if the treatment plan includes the use of chemotherapy
Not clear from the table below what proportion of patietns did not have chemotherapy planned. Would be useful to have this percentage written though I presume that the 5 patient with chemo start date being unknown are the ones where chemotherapy was not planned.
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tart radiotherapy
For this data it would be quite useful to also include a histogram showing the distribution of days as some paitents have a very large number of days. Would be useful to discuss here what was the number of days post registration at TMC that RT was started. This would help clarify the issues related to delay in referrals.
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laboratories
laboratory
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6 (3, 15)
Check if any one had a negative date.
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VCR-CDDP-cyclophosphamide 10 (23%) VCR-CDDP-Cyclophosphamide 6 (14%) VCR-CDDP-CYCLOPHOSPHAMIDE 6 (14%)
Needs harmonization.
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_acute_pancytopenia
This means all thre lineages had grade 3 toxicity. Were the anemia, leucopenia, lymphopenia, neutropenia and thrombocytopenia etc separated.
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1. > 3 years old 41 (89%) 2. 3-4 years old 5 (11%)
Does not make sense. I think it should < 3 year old ??
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ACNS 9961 3 (6.4%) ACNS A9961 3 (6.4%) ACNS9961 1 (2.1%)
Similarly needs harmonization
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COG-POG A9961 1 (2.1%) COG-POG- A9961 1 (2.1%) COG-POG-A9961 1 (2.1%)
Thsese seem to be same. This section need harmonization.
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Cohort studies
Write Eligible Instead
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- Apr 2024
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hbiostat.org hbiostat.org
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Example notion of power: probability that PP will exceed a certain value such as 0.95 (Bayesian assurance)
PP = Posterior Probability
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similarity interval for
Say for example, we have a trial comparing two treatments A & B where B is likely to result in improved outcomes. Say the minimum clinically important benefit from B over A is 5% (e.g. 5% improvement in the overall survival). Then: $$\delta\;= \;5\% $$ $$\gamma\;=\;1.67\% $$ $$Similarity\;Interval\; =\; -2.5\%\; to\; +2.5\% $$
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the prior used in the analysis is not in conflict with the prior used by the judge of the accuracy of the study results
What does this line actually mean.
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Frequentist OCs deal with what may happen under unknowable assumptions about the treatment effect generating the data.
This is a very important point to note.
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- Jan 2024
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hbiostat.org hbiostat.org
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dataChk
This requires the data to be data.table. if it is a dataframe possibly does not work ?
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course.recode-with-r.com course.recode-with-r.com
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questions
Now you can directly comment on the website. Please use the functionality
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