Typically, a hemolytic attack starts with malaise, weakness, and abdominal or lumbar pain. Within a time frame of several hours to 2–3 days, the patient develops jaundice and often dark urine. T

G6PD is a housekeeping enzyme critical in the redox metabolism of all aerobic cells (Fig. 105-1). In red cells, its role is even more critical because it is the only source of NADPH, which directly and via GSH defends these cells against oxidative stress