if you tell people that they have a genetic predisposition to certain health characteristics, such as a low capacity for exercise or a tendency to overeat, their bodies start to respond accordingly. Even if their DNA does not actually contain the gene variants in question.
I think if someone does tell you about this genetic disposition about overeating or not exercising, and our body tends to respond differently it's because our mind is telling our body that we need to slow down and watch what we eat and then we make plans to go to the gym or for runs.