What is CRF? (Intuitive explanation)
This is way over-explained by AI. An external reference (even Wikipedia) would do it enough justice.
As a general note, the site could offload some of the "clutter" by reference linking.
12 Matching Annotations
- May 2026
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unjournal.github.io unjournal.github.io
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unjournal.github.io unjournal.github.io
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Process Mode (realized)
Is a blend of different densities attainable in one facility?
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Cheap
How is "cheepness" defined?
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Hydrolysates Adopted
This is surprising. With 30k simulations, the mean of the simulated outcomes shouldn't deviate much from the slider's value. In my case I see 73% while the P(hydro) on a slider is 0.75 -- I'd expect the two to match.
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Distributions
With arbitrary parameterisation the plots are somewhat unnecessary. Parameterisation is already discussed in Model Formulas and Metrics tab.
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unjournal.github.io unjournal.github.io
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relative sizes shift dramatically based on technology adoption
Probably the most important conclusion. When adoption low and tech costs high, all other model components become an afterthought.
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Code { const mediaLabel = bundled_media ? "Complete Media (incl. GFs)" : "Media (incl. basal micros)"; const allComponents = [ {name: mediaLabel, value: mean(results.cost_media), color: "#27ae60"}, {name: "Growth Factors", value: mean(results.cost_recf), color: "#9b59b6"}, {name: "Supplemental Proteins", value: mean(results.cost_supp_protein), color: "#e67e22"}, {name: "Other VOC", value: mean(results.cost_other_var), color: "#7f8c8d"}, {name: "CAPEX (annualized)", value: mean(results.cost_capex), color: "#e74c3c"}, {name: "Plant overhead OPEX", value: mean(results.cost_fixed), color: "#f39c12"}, {name: "CDMO Toll", value: mean(results.cost_cdmo_toll), color: "#e67e22"}, {name: "Downstream", value: mean(results.cost_downstream), color: "#1abc9c"} ]; // Filter out zero-value components (e.g., downstream when not included) const components = allComponents.filter(c => c.value > 0.001).sort((a, b) => b.value - a.value); const total = components.reduce((s, c) => s + c.value, 0); const chartContainer = document.createElement("div"); chartContainer.style.position = "relative"; // Expand/collapse button const expandBtn = document.createElement("button"); expandBtn.textContent = "Expand Chart"; expandBtn.style.cssText = "padding: 0.3rem 0.7rem; font-size: 0.8rem; cursor: pointer; border: 1px solid #ccc; border-radius: 4px; background: #f8f9fa; margin-bottom: 0.5rem;"; let expanded = false; expandBtn.onclick = () => { expanded = !expanded; expandBtn.textContent = expanded ? "Collapse Chart" : "Expand Chart"; chartEl.replaceWith(makeChart(expanded)); chartEl = chartContainer.querySelector(".cost-breakdown-plot"); }; chartContainer.appendChild(expandBtn); function makeChart(large) { const w = large ? 1200 : 1000; const h = large ? 700 : 580; const fontSize = large ? 14 : 13; const p = Plot.plot({ width: w, height: h, marginLeft: 200, marginRight: 140, x: { label: "Average Cost ($/kg)", grid: true }, y: { label: null }, marks: [ Plot.barX(components, { y: "name", x: "value", fill: "color", sort: {y: "-x"} }), Plot.text(components, { y: "name", x: d => d.value + 0.5, text: d => `$${d.value.toFixed(2)} (${(d.value/total*100).toFixed(0)}%)`, textAnchor: "start", fontSize: fontSize }) ], title: `Cost Breakdown by Component (Total: $${Math.round(total)}/kg)` }); p.classList.add("cost-breakdown-plot"); return p; } let chartEl = makeChart(false); chartContainer.appendChild(chartEl); return chartContainer; } Expand Chart
Expand/Collapse Chart button doesn't seem to do anything in my browser (Safari, Mac OS Tahoe 26.4.1)
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30,000
Sure? In the model that we reviewed it was 200k.
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unjournal.github.io unjournal.github.io
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Key structural issues
what's missing in this section: * the model relies fully on synthetically generated data (as opposed to empirical) * parameter/variable choices are largely arbitrary (though with clear links to actual practice, of course) * there's a varying level of granularity in model components -- some variables are lumped together into higher-order categories for simplicity's sake
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Sensitivity analysis:
sensitivity testing is not a structural issue of the model -- consider either moving to a section dedicated to model testing or remove
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sensitivity analysis caveats
irrelevant, please remove
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unjournal.github.io unjournal.github.io
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missing supplemental protein costs (albumin/transferrin/insulin), and the sensitivity chart being a dollar-swing ranking rather than a variance decomposition. We are addressing these incrementally.
The observations mentioned are technicalities. More prominently, the review observed: strong (sometimes very) assumptions related to variables, their distributions and relationships between them.
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