If the interstitial fluid is hypotonic, water will enter the cell
When the interstitial fluid becomes hypertonic, what happens to a cell?
If the interstitial fluid is hypotonic, water will enter the cell
When the interstitial fluid becomes hypertonic, what happens to a cell?
When your body starts to run low on water, a number of changes take place: for one, the volume of your blood decreases, causing a change in blood pressure.
Your blood volume decreases and the concentration of minerals increases when your body loses water. The body modifies blood pressure, heart rate, and renal function to correct this, but thirst is the primary indicator you observe.
If the adipose tissue, liver, and muscles demand glucose, this will lead to increased insulin supply by the β-cells.
The body produces more insulin but excretes less of it in those who are insulin resistant. Stable glucose is maintained by healthy β-cells regulating insulin levels. Type 2 diabetes may result from inadequate glucose control caused by β-cell impairment.
The chemical process of digestion begins during chewing as food mixes with saliva, produced by the salivary glands.
Saliva and chewing are the first steps in digestion because they moisten and break down food. In order to get food into the stomach rather than the lungs, the tongue forces the food (bolus) into the pharynx, where the epiglottis closes the airway.
The stomach and other parts of the gastrointestinal tract produce peptides that can function as hormones,
Hormones such as CCK are released by the stomach to communicate with the brain. CCK may cause discomfort rather than actual fullness when it reduces meal size.
homeostasis when deviations from it are detected.
Like a thermostat regulating the temperature, homeostasis detects deviations from a predetermined point and initiates reactions to restore the optimal state.
Early recognition and diagnosis of narcolepsy could be significant for certain treatment possibilities.
It's critical to diagnose narcolepsy early since immune-based therapies may be beneficial if administered shortly after onset. T-cell activity is one indicator that may assist identify the illness before significant brain cell death takes place.
Both the caffeine in coffee and the theophylline in tea are examples of such adenosine antagonists and are well known for their stimulant effects.
By inhibiting the drowsy-inducing molecule adenosine, caffeine keeps us awake. According to studies, the longer we are awake, the higher our adenosine levels are; increasing them results in sleep, while inhibiting them improves alertness.
NREM sleep
The thalamus, which regulates what enters the brain's cortex, blocks awake signals during NREM sleep. This demonstrates how intricate brain connections regulate the stages of sleep.
REM sleep is a distinct, homeostatically controlled brain state characterized by an activated electroencephalogram (EEG) in combination with paralysis of skeletal muscles and is associated with vivid dreaming.
Energy conservation is aided by sleep, particularly for animals with fast metabolisms. Additionally, it helps the immune system, which may combat disease by using the energy it has stored.
This theory states that we sleep to conserve energy and is based on the fact that the metabolic rate is lower during sleep. The theory predicts that total sleep time and NREM sleep time will be proportional to the amount of energy expended during wakefulness
According to this notion, because sleep slows down our metabolism, we sleep to conserve energy. Energy-demanding animals typically sleep longer. The immune system, which expends energy battling disease, benefits from sleep as well.
Integrated Information Theory of Consciousness (IITC)
Although IITC views consciousness as levels, certain states, such as sedation or dreaming, may represent distinct types rather than merely more or less. These states were measured by Casali et al.
The phenomenon of working memory is made all the more complex by the fact that it takes place over time. For example, the experimental results illustrated below show how various areas of the subjects’ brains alter their activity levels as the subjects are presented with various visual stimuli. When the subjects are shown a blurred image, the activity level (represented by the blue bars in the graph) becomes highest in area 1, the visual part of the brain. When the subjects are shown an image of a face, brain activity (black bars) becomes highest in the associative and frontal regions (4, 5, and 6). Lastly, when the subjects are retaining an image of a face in their working memory, brain activity (red bars) is highest in the frontal regions, while the visual areas are scarcely stimulated at all.
When processing and storing visual inputs in working memory, how does activity in various parts of the brain change?
considered here is sometimes referred to as organic amnesia,
Dissociative amnesia is caused by psychological trauma, whereas organic amnesia is caused by brain damage. The latter is frequently transient but is still debatable; it impacts autobiographical memory and may involve a fugue state.
memory within the confines of the cerebral cortex"
There was an anti-localization bias as a result of Lashley's study, which focused on the cerebral cortex in memory. However, subsequent studies contradicted his findings by demonstrating the importance of the hippocampus for memory and learning.
A fascinating research enterprise contributing greatly to our understanding of memory is the case of H.M. (e.g. Henry Molianson)
The case of H.M. demonstrated how important the hippocampus is for creating new, long-term memories. He demonstrated the difference between various memory systems by being unable to retain new explicit memories, even though his previous memories and procedural learning remained intact.
classical conditioning,
Classical conditioning shapes behavior by associating experiences with stimuli. It is impacted by evolution and is stronger when presented with unique and meaningful inputs. It is nevertheless essential for researching learning and brain function despite its simplicity.
By contrast, learned behavioral adaptations can change moment to moment and, as discussed above, may be transmitted (in some species) to future generations by cultural transmission
Humans can pass on and improve learned habits from one generation to the next through cultural transmission, guaranteeing ongoing advancement.
Some people may even become dependent on them.
What are the hazards of long-term use and abrupt withdrawal of benzodiazepines, and why is it necessary that they be recommended for short-term use?
More than half of the drug overdose deaths in the United States each year are caused by prescription drug misuse
Overdoses from prescription drugs, frequently combining benzodiazepines and opioids, have varied throughout time, with fentanyl being associated with a notable increase. Fentanyl is a major contributor to the opioid problem because its presence in the drug supply has led to a large increase in overdose deaths.
Decades of research supported by NIDA has proven that addiction is a complex brain disease characterized by compulsive, at times uncontrollable, drug craving, seeking, and use that persist despite potentially devastating consequences.
Excessive drug use and strong dopamine spikes are the main causes of addiction, a neurological disorder. These spikes reorient priorities toward drug-seeking behavior by simulating natural pleasure while impairing the brain's reaction to normal rewards.
All these drugs are dopamine agonists
What effects do various dopamine agonists have, and how do psychoactive substances affect synaptic communication?
The liver produces enzymes (proteins that speed up a chemical reaction), and these enzymes help catalyze a chemical reaction that breaks down psychoactive drugs
Cytochrome P450 enzymes in the liver break down psychoactive substances. Metabolic tolerance brought on by repeated use may necessitate greater dosages. Enzymes are induced by some medications, such as alcohol, which speeds up breakdown and increases the risk of liver injury.
(these are called agonists) or decrease it (antagonists).
While antagonists lessen the usual excitatory or inhibitory action of a neurotransmitter, agonists increase it. Opioids improve inhibition, amphetamines boost excitation, while naloxone and other blockers lessen the effects of opioids.
electrical synapses current,
Through direct connections, electrical synapses enable bidirectional communication between neurons and are faster. In contrast to chemical synapses, which only transfer signals in one direction, they are employed in systems that need fast reactions, such as reflexes.
neurotransmitters is one type of synaptic transmission
Neurons can interact chemically through neurotransmitters or electrically through direct connections, a process known as synaptic transmission. Chemical transmission is more intricate and essential for brain processes including behavior and information processing.
The neuronal cell membrane, which is composed of a lipid bilayer of fat molecules,
Ion channels in the neuronal cell membrane allow ions to flow through while also dividing the cell's inside from its exterior. A resting potential is produced by the variation in ion concentration and charge.
the neuron's resting voltage a negative bias
Ion concentrations determine the resting voltage, which is produced by neurons using sodium, potassium, chloride, and organic anions.
Unmyelinated axons
Myelinated A fibers convey pain more quickly and sharply than unmyelinated axons, which transfer slower impulses, such as C fibers for aching pain.
The function of the myelin sheath and the nodes
Saltatory conduction is the process by which nerve impulses "jump" from node to node, accelerated by the myelin sheath and nodes.
tropic hormones
The anterior pituitary is known as the "master gland" because it creates tropic hormones and growth hormone, controlling other endocrine glands. As the "master" of the "master gland," the hypothalamus regulates both the anterior and posterior pituitaries.
endocrine system
Although being distinct from the neurological system, the endocrine system uses hormones to affect bodily functioning. These hormones have long-lasting effects and impact different cells as they move through the bloodstream.
Cranial nerves (Figure 4.5.34.5.3\PageIndex{3}) are in the head and neck and connect directly to the brainstem. There are twelve cranial nerves,
The middle part of the brain is connected to a total of twelve cranial nerves, which regulates motor and sensory processes in the head and neck. Some handle both roles.
The spinal cord serves as an information superhighway.
Reflexes are controlled by the spinal cord, which also sends instructions from the brain to the body.
gray matter of the human brain
Gray matter makes up the cerebrum, which affects conscious processes including memory, reasoning, and perception. It consists of deeper areas as well as the cerebral cortex.
increasingly complex
The organization of the nervous system is based on the growth of an embryo, and it goes from an easy structure to a complicated one.
Bipolar neurons
I do want to know what role does the biopolar neutrons play in sensory perception?.
maternal nurturing
What effects does maternal care have on the development of the rat's brain and stress responses?
700 neural connections created each second
Soemthing that I did not know and that I thought was interesting was that more than 700 new brain connections are formed every second in early life, influencing social, emotional, and cognitive development.
histone modifications
What effects do histone changes have on long-term behavior and gene expression?
identical twins share a common genotype
A fact that I thought was interesting to me was that differences in behavior, personality, and health concerns can result from identical twins increasingly distinct epigenetic patterns as they get older.
human behavior.
In what ways does contemporary genetics contradict our conception of moral equality and human behavior?
genetics
Something that I thought was interesting was that even characteristics like political beliefs, television viewing habits, and divorce rates can be impacted by genetics.
twin studies
In what ways can twin studies aid in our comprehension of how environment and genetics influence human characteristics?
So today America does remember the hundreds of men used in research without their knowledge and consent. We remember them and their family members. Men who were poor and African American, without resources and with few alternatives, they believed they had found hope when they were offered free medical care by the United States Public Health Service. They were betrayed.
What was the effect on healthcare trust of the unethical treatment of African American men in medical research?
However, single cell recordings are usually extracellular (outside of the cell). That is, they don’t record from inside a single cell but, rather, they record from outside a few cells. Also, consider that the neuron that responds to a line in a particular location that is moving in a particular direction likely does not respond to much else. So, it is extremely difficult to determine what exactly each cell does through single cell recordings. Recording from one area ignores what is happening everywhere else in the brain
A fact that I thought was cool was that single cell recordings detect brain activity from external cells, but because each cell is so specialized, it can be hard to identify exactly what it does.
fMRI measures the change in the concentration of oxygenated hemoglobin, which is known as the blood-oxygen-level-dependent (BOLD) signal
My annotation does go for this whole paragraph, but I did think that it is fascinating that Instead of directly measuring brain activity, fMRI monitors blood flow, which allows us to see changes in oxygen levels that indicate brain activity.
Electroencephalography (EEG) is one technique for studying brain activity. This technique uses at least two and up to 256 electrodes to measure the difference in electrical charge (the voltage) between pairs of points on the head. These electrodes are typically fastened to a flexible cap (similar to a swimming cap) that is placed on the participant’s head. Figure 2.3.12.3.1\PageIndex{1} shows a patient wearing such a cap. From the scalp, the electrodes measure the electrical activity that is naturally occurring within the brain. They do not introduce any new electrical activity.
I did not mean to highlight this whole thing but I was wondering if the patient does feel the volatage that would be happening and if it is a uncomfortable feeling.
Raymond Damadian
What role did Raymond Damadian's finding have in the advancement of MRI tumor detection technology?
X-rays can depict a two-dimensional image of a body region, and only from a single angle. In contrast, more modern medical imaging technologies produce data that are integrated and analyzed by computers to produce three-dimensional (3D) images or images that reveal aspects of the body functioning.
Modern imaging technologies, as opposed to X-rays, use advanced computer processing to provide 3D images and functional data, providing more in-depth understanding of the body.
Functional imaging techniques allow researchers to learn about the brain activity during various tasks by creating images based on the electrical activity or the absorption of various substances that occurs while a subject is engaging in a task. Such techniques can be used, for example, to visualize the parts of the brain that respond when we're exposed to stimuli that upset us or make us happy.
How can brain activity during emotional or cognitive tasks be seen using functional imaging techniques?
ructural imaging techniques are useful in many situations such as locating tumors, sites of physical brain damage, or finding size differences between the structures of the brain between various groups
How may brain abnormalities or group differences be identified using structural imaging techniques?