They will be more advanced than we are, in science and in useful arts, and will know best what will suit the circumstances of their day.
Today, Jefferson's prediction is correct. Science has not only advanced tremendously since 1818, but the University has also introduced new science disciplines, including computer science. According to the University's website, computer science as a discipline started in 1970. In 1984, computer science became an independent department. Today, over 1,000 students are enrolled in one of three UVA undergraduate computer degree programs. Ultimately, this department is an example of how UVA has changed over the last two centuries and adapted to the world's current circumstances, just as Jefferson predicted it would.