A pharmaceutical company wants to develop a new antibiotic that is more water soluble than an existing antibiotic. Their strategy will be to add various functional groups to the existing antibiotic and then test the water solubility of the resulting antibiotic. The scientists are trying to decide which functional group(s) to try first. Which one(s) would you recommend and why?
To increase water solubility, we would want polar functional groups, since polar molecules are soluble in polar water. Some polar functional groups are alcohols, carboxylic acids, and aldehydes.