ICER1 gen

DICER1 syndrome

disrupts the biogenesis and processing of miRNAs with subsequent disruption in control of gene

ers included, comparedto the control population: 8% and 0% for women and men, respectively [ 23 ]. Specifically, a recent studyindicated a correlation between truncating germline DICER1 mutations and familial multinodulargoiter, among other cancers [24]. Women are more likely to develop thyroid cancer than men, regardlessof DICER1 variant status [25 ]. Frequent malignant neoplasms of the endocrine system [26 ] such as

Another study confirmed this, indicating that more than 60% of ovarianSertoli–Leydig cell tumors diagnosed harbored DICER1 mutations within the RNase III domain

History: Sertoli–Leydig cell tumor.

e mutation was found to be heterozygous forgermline but hemizygous in the tumor itself

tumorigenesi

, located on chromosome 14, position q32.1