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    Research Progress on the Correlation Between Epigenetics and Schizophrenia
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    1. peter.schanzenbach 03 Nov 2025
      Both genetic and environmental factors are considered as important contributors to the development and progression of this disorder. The environmental factors have been linked to changes in gene expression through epigenetic modulations,

      This sets up the reason epigenetics matters in schizophrenia: not just genetic inheritance but modifiable environmental impacts shape risk and progression. Epigenetic mechanisms such as DNA methylation, ncRNA regulation, histone modification serve as bridges between what you inherit and what you experience.

    2. peter.schanzenbach 03 Nov 2025
      Some schizophrenia- and autism-associated genes, such as DLG4 (disks large homolog 4, MIM 602887), DRD2 (dopamine receptor D2, MIM 126450), NOS1 (nitric oxide synthase 1, MIM 163731), NRXN1 (neurexin-1, MIM 600565), and SOX10 (sex-determining region Y-box 10, MIM 602229), have all been shown to have age-related dynamically methylated changes throughout the entire lifetime, especially in the fetal and postnatal stages

      Key schizophrenia/autism genes with varying lifetime methylation patterns. Important for understanding neurodevelopment. This fits with article summary that epigenetic mechanism like methylation influence schizophrenia development. DLG4, DRD2, NOS1 and SOX10 are genes with varying methylations that influence schizophrenia.

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    frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.688727/full