The observation that certain chromosomes, such as chromosome 3, exhibit significantly higher similarity than others, such as chromosome 5, highlights the importance of analyzing chromosome-specific homology rather than relying on averaged genome-wide comparisons. This heterogeneity suggests that different genomic regions have experienced varying rates of evolution and may be subject to different selective pressures. Further investigation is warranted to understand the underlying mechanisms driving these differences. Potential factors could include varying rates of mutation, recombination, gene duplication, transposition, and horizontal gene transfer.
Measuring gene similarity within each Chromosome (the traditional method of detecting relatedness) would be a very strong supplemental figure to establish a baseline of comparison to GeneCompare. How does the previously biased approach compare to this new unbiased approach?