61 Matching Annotations
  1. Nov 2021
    1. mtDNA has a high mutation rate, and de novo mtDNA mutations create a mixture of mutant and normal mtDNAs in cells, a state known as heteroplasmy. As the proportion of mutant mtDNAs increases, the energy output capacity of the cell declines until there is insufficient energy to sustain cellular function, termed the bioenergetic threshold. Mitochondria also constantly undergo fusion and fission, which permits complementation of mtDNAs in trans

      jeesus

    1. the enemies of free speech and human agency are making a serious mistake, and as sun-tzu advises us, we should not interrupt them.

      "what you resist will persist" or what?

    2. advertising and information scraping will die as a business model in the age of seamless, low-friction micropayments and blockers for malicious content and data intrusion. you will be free to chart your own course, pick your own friends, and decide in the most granular of fashions which trade-offs suit you.

      sounds pretty damn good to me

    1. Ein Computer kann eine Feder nicht als Belohnung für indianische Tapferkeit "erkennen", weil diese Information nicht in der Feder enthalten ist.

      Weil ihm diese Information nicht bekannt ist.

  2. Sep 2021
    1. Focus fully on whatever fascinates you now.

      This is basically how I lived most of my life

    2. Pain’s power relies on surprise.If you expect it, it’s weaker.If you choose it, it’s gone.

      For physical pain, for example through injury, that's totally not true.

    3. Therefore, the way to live is to steer towards the pain.Use it as your compass.Always take the harder option.Always push into discomfort.Ignore your instincts

      This only makes sense because people will automatically never do that 100% xD

    4. If you avoid pain, you avoid what you really want

      Like a massage that is a bit painful but relaxes really good.

    5. Resist the urge to branch out into something new.

      I'm branching back into old important things and try to braid things together. Is that okay?

    6. The more you take on, the less you’ll achieve.

      This whole chapter reminds a lot of the book Essentialism. Funniest reviews on goodreads.com:

      Could have been a 100 pages shorter without losing anything essential


      It must be tough to write a book about Essentialism because people will be watching like a hawk to see whether you stick to your own advice – and sadly I’m not sure that he did.

    7. Most people fail in life not by aiming too high, but by aimingtoo low.

      I always forget because I don't want to disappoint myself. But it's actually more fun to aim high. A reminder to play The Game-Changing Game in real life.

    8. Take tiny breaks when working, to go longer than most

      Reminds me of the Pomodoro method. 25 min of work, 5 min of break (real break) Found an Android App yesterday that looked quite cool, but I've never tried the method so far. Usually I'll take breaks naturally.

    9. Goals only improve your present actions.A good goal makes you take action immediately.

      This is a genius definition, and one that allows to test a goal immediately instead of wondering forever if it's the right goal.

    10. flow of fascinating work

      Reference to Mihaly Csikszentihalyi's "Flow"

    11. scolding

      ausschimpfen, schelten

    12. Stop all the thinking and doing.

      this links really closely to the Tao The Ching

    13. Or have no home at all.
    1. This is a truly stunning vision, a profound integration of Ego and Eco, of Spirit descending into even the lowest state and ascending back to itself, with Spirit nonetheless fully present at each and every stage as the process of its own self-realization and self-actualization, its own self-unfolding and self-enfolding development, a divine play of Spirit present in every single movement of the Kosmos, yet finding more and more of itself as its own Play proceeds, dancing fully and divine in every gesture of the universe, never really lost and never really found, but present from the start and all along, a wink and a nod from the radiant Abyss.

      This is a truly stunning vision, a profound integration of Ego and Eco, of Spirit descending into even the lowest state and ascending back to itself, with Spirit nonetheless fully present at each and every stage as the process of its own self-realization and self-actualization, its own self-unfolding and self-enfolding development, a divine play of Spirit present in every single movement of the Kosmos, yet finding more and more of itself as its own Play proceeds, dancing fully and divine in every gesture of the universe, never really lost and never really found, but present from the start and all along, a wink and a nod from the radiant Abyss.

    2. Schelling's brilliant synthesis and integration of the Ego and the Eco stand in sharp contrast to the plethora of today's approaches to the environment, which still typically pursue either the Egoic-rational calculative adventure ("reform environmentalism"), or fall into various forms of regressive Eco-Romantic "reechantment." Indeed, the Eco-Romantic advocates of the "reenchantment of the world" are still very much with us, and still heavily committed to a vast reinterpretation and recommendation of ontological shallowness, often by simply renaming it "deep." Virtually all of the "new paradigm" schools of thought betray a profound allegiance to the flatland interlocking order (the fundamental Enlightenment paradigm), and then within that flatland they wobble between some version of rationalistic systems theory (mostly the ecomasculinists) or nature as disclosed in sentiments (mostly the ecofeminists). To the extent that either attempts to escape the flatland interlocking order at all, they do so by regression to agrarian alchemy, magico-mythic animism, astrology, horticultural planting mythology, or foraging human-nature indissociation—all of which is based, of course, on

      uff

    3. "In the ultimate dark Abyss of the divine Being, the primal ground or Urgrund, there is no differentiation but only pure identity."

      "Darkness within darkness.

      The gateway to all understanding."

    4. Whatever else we might say, the world does hang together, and evolution does have a direction: Eros as Spirit-in-action.

      Whatever else we might say, the world does hang together, and evolution does have a direction: Eros as Spirit-in-action.

    5. SPIRIT-IN-ACTION

      SPIRIT-IN-ACTION

    6. The Agony of Modernity: Fichte versus Spinoza

      The Agony of Modernity: Fichte versus Spinoza

    7. it came to the same thing: how can you possibly unite Subjective Freedom with Objective Union?

      it came to the same thing: how can you possibly unite Subjective Freedom with Objective Union?

    8. Schelling began, in a sense, by reacting to the Enlightenment notion that rationality alone is the highest Ascent to which we can aspire.

      Schelling began, in a sense, by reacting to the Enlightenment notion that rationality alone is the highest Ascent to which we can aspire.

    9. reflection had, Schelling pointed out, introduced a rift or cleavage between Nature as external object and the reflecting self as subject (which also, he said, made humans objects to themselves – the retroflected monological gaze, as we earlier put it).

      reflecting self as subject (which also, he said, made humans objects to themselves – the retroflected monological gaze, as we earlier put it).

    1. trammelled

      bound, restricted

    2. epistemology

      the theory of knowledge, especially with regard to its methods, validity, and scope, and the distinction between justified belief and opinion.

    3. IBIS
    4. “wicked problems”
    5. “Dialog Mapping”
    6. Global Sensemaking
    7. renegade

      abtrünnig

    8. And also online, after the event, by using Debategraph.
    9. I’ve often wondered if we, humans, are only inanimate matter, which somehow got infected by the desire to survive…

      an intriguing thought.. I always believed that "the desire to survive" is something that "evolved" naturally through "selection" - only the molecules that had the ability to survive survived

    10. A hologram has the property that the whole picture can be reproduced from any of its parts – because the whole is coded and hence present in its parts.

      Really?

    11. defilements

      Deutsch: Schändung, Entweihung, Verunreinigung

  3. Aug 2021
  4. Apr 2021
    1. She doesn’t give even a moment’sthought to right or wrong.

      Reminds of Gon in the Anime "Hunter x Hunter"

    2. Since before time and space were,

      This is 2600 years old..

    3. Stop thinking, and end your problems.

      Write that onto a bridge :D

    4. Throw away holiness and wisdom,and people will be a hundred times happier.

      Adam and Eve?

    5. Do you have the patience to waittill your mud settles and the water is clear?

      Patience is not necessarily one of my strengths

    6. Just realize where you come from

      Biology and evolution helps to understand that

    7. but non-being is what we use.

      What is non-being?

    8. The Master leadsby emptying people’s minds andfilling their cores, by weakening their ambitionand toughening their resolve.

      Doesn't sound too nice.. does it?

    9. That is why it lasts forever

      I don't get it

    10. The tao that can be toldis not the eternal Tao

      Ok but what are you then doing here?

    1. You’ve been compared to Carl Sagan in your ability to convey complex science in an accessible form.

      And Carl Sagan, in turn, was married to Lynn Margulis, another great scientist!

    1. T IS FLAT-OUT strange that something—that anything—is happening at all. There was nothing, then a Big Bang, then here we all are. This is extremely weird.

      Yep

    1. For a million years, people looked at the moon and wanted to walk on it. . . .

      love that

    2. new knowledge comes when you simply bear in mind what you need to know. Keep holding the problem in mind, and it will yield.

      so true