’Tis evident, that all the sciences have a relation, greater or less, to human nature; and that however wide any of them may seem to run from it, they still return back by one passage or another. Even Mathematics, Natural Philosophy, and Natural Religion, are in some measure dependent on the science of Man; since they lie under the cognizance of men, and are judged of by their powers and faculties.
Hume is arguing that almost everything relates to human nature and we can find lots of things from these sciences that come from human nature. He says men of science are criticized by states and governments. Hume's audience is English readers which is later translated into other European countries. David Hume makes a great point that we should be skeptical and we should question why things are the way they are. This goes with metaphysics. His weakness are that its hard to understand his writing or at least it took a couple of reads for me to understand the point that he was trying to make. Overall, I think Hume was a critical thinker about why things came to be. As like most philosophers during his time, he was not liked by governments because he raised questions about liberties and rights.