- Last 7 days
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en.wikipedia.org en.wikipedia.org
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Mendelian randomization (commonly abbreviated to MR) is a method using measured variation in genes to examine the causal effect of an exposure on an outcome
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- Aug 2023
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www.fharrell.com www.fharrell.com
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fear of setting the bar too high for potential biomarkers
There is an "urgent need" to have companion diagnostics for targeted therapy. This has two parts: (a) having a biomarker to target for therapy, and (b) being able to reliably assess the biomarker for therapy. Given the pressures of the pipeline to develop new drugs, there appears to be an inclination to be eager to propose a new target biomarker without rigorous validation, with the fear that with current sample sizes the rigor will put the kibosh on the biomarker.
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- Aug 2022
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www.publichealth.columbia.edu www.publichealth.columbia.edu
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A major caveat of the cause-specific approach is that it still assumes independent censoringfor subjects who are not actually censored but failed from competing events, as for standard censorship such as loss to follow up.
This is the crucial bit. KM works under independent censoring, but there are no guarantees that the competing risks are independent.
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- May 2022
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www.neelnanda.io www.neelnanda.io
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finding new projects that I feel excited about, reframing tasks I need to do anyway into ones I feel excited about, and feeling excited about self-improvement
This is a neat way of framing things positvely
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www.neelnanda.io www.neelnanda.io
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Notice when you say “oh, I can do this tomorrow” and do it today.
This is a key concept
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