387 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Plausible, robust biological oscillations through allelic buffering
    1
    1. scibot 15 Nov 2024
      RRID:AB_10956588

      DOI: 10.1016/j.cels.2024.10.002

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    sciencedirect.com/science/article/pii/S2405471224002990
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma
    1
    1. scibot 07 Nov 2024
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      DOI: 10.1002/mc.23610

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    pmc.ncbi.nlm.nih.gov/articles/PMC10592327/
  4. Oct 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
    1
    1. scibot 05 Oct 2024
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      DOI: 10.1101/2024.09.09.612106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  6. Sep 2024
  7. www.biorxiv.org www.biorxiv.org
    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
    1
    1. scibot 28 Sep 2024
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      DOI: 10.1101/2024.09.20.613717

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    biorxiv.org/content/10.1101/2024.09.20.613717v1
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    EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization
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    1. scibot 27 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114781

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    sciencedirect.com/science/article/pii/S221112472401132X
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    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.isci.2024.110893

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    sciencedirect.com/science/article/pii/S2589004224021187
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    Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
    1
    1. scibot 25 Sep 2024
      RRID:AB_2651128

      DOI: 10.1016/j.celrep.2021.109018

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    sciencedirect.com/science/article/pii/S2211124721003326
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
    1
    1. scibot 25 Sep 2024
      RRID:AB_10956589

      DOI: 10.1016/j.ccell.2019.11.003

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    sciencedirect.com/science/article/pii/S1535610819305239
  12. www.sciencedirect.com www.sciencedirect.com
    Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
    1
    1. scibot 25 Sep 2024
      RRID:AB_10953628

      DOI: 10.1016/j.chom.2019.02.003

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    sciencedirect.com/science/article/pii/S193131281930099X
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    Protofilament-specific nanopatterns of tubulin post-translational modifications regulate the mechanics of ciliary beating
    1
    1. scibot 13 Sep 2024
      RRID:AB_10956588

      DOI: 10.1016/j.cub.2024.08.021

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    sciencedirect.com/science/article/pii/S0960982224011333
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.014

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    sciencedirect.com/science/article/pii/S009286742400905X
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    Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114695

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    sciencedirect.com/science/article/pii/S2211124724010465
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
    1
    1. scibot 05 Sep 2024
      RRID:AB_10956588

      DOI: 10.1152/ajpcell.00654.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC11371365/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex
    1
    1. scibot 04 Sep 2024
      RRID:AB_10956588

      DOI: 10.1126/sciadv.ado1148

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    ncbi.nlm.nih.gov/pmc/articles/PMC11364093/
  18. Aug 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
    1
    1. scibot 29 Aug 2024
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      DOI: 10.1016/j.xcrm.2024.101700

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    sciencedirect.com/science/article/pii/S266637912400421X
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    Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
    1
    1. scibot 23 Aug 2024
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      DOI: 10.1016/j.cmet.2024.07.020

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    sciencedirect.com/science/article/pii/S1550413124002912
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    Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114616

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    sciencedirect.com/science/article/pii/S2211124724009665
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114617

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    sciencedirect.com/science/article/pii/S2211124724009677
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    Structural requirements for activity of Mind bomb1 in Notch signaling
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.str.2024.07.011

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    sciencedirect.com/science/article/pii/S0969212624002740
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor intrinsic activity of Chromobox 2 (CBX2) remodels the tumor microenvironment in high grade serous carcinoma
    1
    1. scibot 19 Aug 2024
      RRID:AB_10956588

      DOI: 10.1158/2767-9764.CRC-24-0027

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    ncbi.nlm.nih.gov/pmc/articles/PMC11298703/
  25. academic.oup.com academic.oup.com
    DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo
    1
    1. scibot 02 Aug 2024
      RRID:AB_10956588

      DOI: 10.1093/hmg/ddaa037

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    academic.oup.com/hmg/hmg/advance-article-abstract/doi/10.1093/hmg/ddaa037/5803135
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
    1
    1. scibot 01 Aug 2024
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      DOI: 10.1016/j.molcel.2024.07.003

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    sciencedirect.com/science/article/pii/S1097276524005793
  27. Jul 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.ccell.2024.06.012

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    sciencedirect.com/science/article/pii/S153561082400237X
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BTK acts as a modulator of the response to imatinib in chronic myeloid leukemia
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    1. scibot 20 Jul 2024
      RRID:AB_10956588

      DOI: 10.3892/ol.2024.14557

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    ncbi.nlm.nih.gov/pmc/articles/PMC11253089/
  30. www.sciencedirect.com www.sciencedirect.com
    Interface-guided phenotyping of coding variants in the transcription factor RUNX1
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114436

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    sciencedirect.com/science/article/pii/S2211124724007654
  31. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 18 Jul 2024
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      DOI: 10.1111/bph.16439

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16439
  32. www.cell.com www.cell.com
    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.molcel.2024.06.008

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    cell.com/molecular-cell/fulltext/S1097-2765(24)00511-2
  33. www.sciencedirect.com www.sciencedirect.com
    Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.str.2024.06.010

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    sciencedirect.com/science/article/pii/S0969212624002284
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor activity and stabilizing ER–mitochondrial junctions
    1
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      DOI: 10.1242/jcs.261728

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    ncbi.nlm.nih.gov/pmc/articles/PMC11234384/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to study CCT-mediated folding of Gβ5 by single-particle cryo-EM
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    1. scibot 07 Jul 2024
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      DOI: 10.1016/j.xpro.2024.103116

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    ncbi.nlm.nih.gov/pmc/articles/PMC11215110/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
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      DOI: 10.1101/2024.06.11.598439

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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  37. Jun 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia
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      DOI: 10.1016/j.xcrm.2024.101614

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    sciencedirect.com/science/article/pii/S2666379124003185
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    Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor
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      DOI: 10.1016/j.cmet.2024.05.010

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    sciencedirect.com/science/article/pii/S1550413124001864
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    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
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      DOI: 10.1016/j.jbc.2024.107469

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    sciencedirect.com/science/article/pii/S0021925824019707
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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      DOI: 10.1016/j.intimp.2024.112374

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    sciencedirect.com/science/article/pii/S1567576924008944
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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      DOI: 10.1016/j.isci.2024.109984

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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
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    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
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      DOI: 10.1016/j.isci.2024.109940

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    sciencedirect.com/science/article/pii/S2589004224011623
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
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    1. scibot 04 Jun 2024
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      DOI: 10.1186/s40478-024-01785-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  45. May 2024
  46. www.sciencedirect.com www.sciencedirect.com
    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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  54. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  89. Dec 2023
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    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
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    Recruitment of FBXO22 for Targeted Degradation of NSD2
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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  104. Oct 2023
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    Unbiased discovery of natural sequence variants that influence fungal virulence
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    Blocking oligomerization is the most viable strategy to inhibit STING
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
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  111. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
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    Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain
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    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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  119. Aug 2023
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    Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
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  126. Jul 2023
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    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    Development of a human iPSC-derived placental barrier-on-chip model
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer
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  133. Jun 2023
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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  140. May 2023
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    General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    Bacterial NLR-related proteins protect against phage
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling
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  148. Apr 2023
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers
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  155. Mar 2023
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    Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models
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  163. Feb 2023
  164. www.embopress.org www.embopress.org
    Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis
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    Inducing primary brainstem gliomas in genetically engineered mice using RCAS/TVA retroviruses and Cre/loxP recombination
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  166. www.nature.com www.nature.com
    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  168. Jan 2023
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    CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway
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  170. www.biorxiv.org www.biorxiv.org
    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Recurrent evolution of an inhibitor of ESCRT-dependent virus budding and LINE-1 retrotransposition in primates
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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  220. Feb 2022
  221. www.sciencedirect.com www.sciencedirect.com
    Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia
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  222. Jan 2022
  223. elifesciences.org elifesciences.org
    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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      DOI: 10.7554/eLife.73137

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  224. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15744

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  225. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward
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      DOI: 10.1111/ejn.15596

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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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      DOI: 10.1016/j.isci.2021.103725

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    Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
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      DOI: 10.1016/j.cell.2021.12.021

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    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
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      DOI: 10.1016/j.isci.2021.103650

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  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis
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      DOI: 10.1016/j.isci.2021.103551

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