398 Matching Annotations
  1. Mar 2022
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8927994/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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    ncbi.nlm.nih.gov/pmc/articles/PMC8914552/
  4. journals.lww.com journals.lww.com
    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
    1
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      DOI: 10.4103/1673-5374.335163

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    journals.lww.com/nrronline/Fulltext/2022/17090/Urolithin_A_alleviates_blood_brain_barrier.32.aspx
  5. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    1. scibot 04 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722000705
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.69982

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    ncbi.nlm.nih.gov/pmc/articles/PMC8860447/
  7. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.72849

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    elifesciences.org/articles/72849
  8. Feb 2022
  9. www.sciencedirect.com www.sciencedirect.com
    CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson’s disease
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      DOI: 10.1016/j.phrs.2022.106133

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    sciencedirect.com/science/article/pii/S1043661822000780
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    FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression
    1
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    sciencedirect.com/science/article/pii/S2211124722001176
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
    1
    1. scibot 13 Feb 2022
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    sciencedirect.com/science/article/pii/S2589004222001298
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis
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    1. scibot 04 Feb 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8806187/
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    Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A
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    1. scibot 02 Feb 2022
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    sciencedirect.com/science/article/pii/S2211124722000213
  14. Jan 2022
  15. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 28 Jan 2022
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      DOI: 10.1111/bph.15773

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15773
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    SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model
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    1. scibot 26 Jan 2022
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    sciencedirect.com/science/article/pii/S2352396421006022
  17. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    1. scibot 26 Jan 2022
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    sciencedirect.com/science/article/pii/S2211124722000146
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production
    1
    1. scibot 22 Jan 2022
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      DOI: 10.3389/fimmu.2021.760138

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    ncbi.nlm.nih.gov/pmc/articles/PMC8767095/
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
    1
    1. scibot 11 Jan 2022
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    sciencedirect.com/science/article/pii/S1097276521010686
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    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
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      DOI: 10.1016/j.devcel.2021.12.015

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    sciencedirect.com/science/article/pii/S1534580721010352
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    Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
    1
    1. scibot 07 Jan 2022
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    sciencedirect.com/science/article/pii/S1074761321005355
  22. Dec 2021
  23. www.sciencedirect.com www.sciencedirect.com
    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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    1. scibot 22 Dec 2021
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    sciencedirect.com/science/article/pii/S221112472101634X
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    Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis
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    1. scibot 21 Dec 2021
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    sciencedirect.com/science/article/pii/S2589004221015066
  25. www.sciencedirect.com www.sciencedirect.com
    Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity
    1
    1. scibot 18 Dec 2021
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      DOI: 10.1016/j.isci.2021.103514

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    sciencedirect.com/science/article/pii/S2589004221014851
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    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
    1
    1. scibot 11 Dec 2021
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    sciencedirect.com/science/article/pii/S2589004221015091
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia
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    1. scibot 11 Dec 2021
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      DOI: 10.1016/j.isci.2021.103434

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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
    1
    1. scibot 08 Dec 2021
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      DOI: 10.7554/eLife.73215

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    ncbi.nlm.nih.gov/pmc/articles/PMC8635982/
  29. www.sciencedirect.com www.sciencedirect.com
    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
    1
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      DOI: 10.1016/j.ebiom.2021.103725

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    sciencedirect.com/science/article/pii/S2352396421005193
  30. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
    1
    1. scibot 03 Dec 2021
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      DOI: 10.1038/s42003-021-02842-3

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    nature.com/articles/s42003-021-02842-3
  31. Nov 2021
  32. www.sciencedirect.com www.sciencedirect.com
    LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
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    1. scibot 24 Nov 2021
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    sciencedirect.com/science/article/pii/S2211124721015205
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The multicellular signalling network of ovarian cancer metastases
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      DOI: 10.1002/ctm2.633

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    onlinelibrary.wiley.com/doi/10.1002/ctm2.633
  34. www.sciencedirect.com www.sciencedirect.com
    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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    1. scibot 10 Nov 2021
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    sciencedirect.com/science/article/pii/S2211124721014479
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation
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    1. scibot 09 Nov 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8551082/
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    Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics
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    sciencedirect.com/science/article/pii/S2589004221013080
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    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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    sciencedirect.com/science/article/pii/S2211124721013991
  38. Oct 2021
  39. journals.physiology.org journals.physiology.org
    Vitamin D/VDR signaling inhibits colitis by suppressing HIF-1α activation in colonic epithelial cells
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      DOI: 10.1152/ajpgi.00061.2021

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    journals.physiology.org/doi/abs/10.1152/ajpgi.00061.2021
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    sciencedirect.com/science/article/pii/S2211124721012316
  41. Sep 2021
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    Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming
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    sciencedirect.com/science/article/pii/S1550413121004216
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    AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke
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    sciencedirect.com/science/article/pii/S2211124721011402
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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    sciencedirect.com/science/article/pii/S2211124721011062
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    Activating a collaborative innate-adaptive immune response to control metastasis
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    sciencedirect.com/science/article/pii/S1535610821004451
  46. Aug 2021
  47. www.sciencedirect.com www.sciencedirect.com
    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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      DOI: 10.1016/j.cell.2021.07.020

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    sciencedirect.com/science/article/pii/S0092867421008795
  48. www.immunohorizons.org www.immunohorizons.org
    3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice
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      DOI: 10.4049/immunohorizons.2100028

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  103. Apr 2021
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    Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras
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  108. Mar 2021
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    Proteogenomics of glioblastoma associates molecular patterns with survival
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  111. Feb 2021
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    Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
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    Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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    Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1‐dependent mitochondrial fission
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    NF-κB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells
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    Iron Potentiates Microglial Interleukin‐1β Secretion Induced by Amyloid‐β
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  119. Jan 2021
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    Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
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    A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
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  124. Nov 2020
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    Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling
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  127. Oct 2020
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    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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      NFκB (p65)

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  131. Sep 2020
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    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
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    Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
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    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis
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  137. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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  138. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
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    Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity
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    PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
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    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
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    Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia
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    Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis
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      rabbit NF-κB p65 (D14E12) XP™

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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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  153. jvi.asm.org jvi.asm.org
    Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling
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    Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT
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    Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice
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  156. Jan 2020
  157. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression
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    Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
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    Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
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    Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia
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    Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
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    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Expression of the double‐stranded RNA‐dependent kinase PKR influences osteosarcoma attachment independent growth, migration, and invasion
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    Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways
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    Neuroprotective effects of an engineered commensal bacterium in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine Parkinson disease mouse model via producing glucagon‐like peptide‐1
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    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors
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    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
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    Loganetin protects against rhabdomyolysis‐induced acute kidney injury by modulating the toll‐like receptor 4 signalling pathway
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    Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation
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