810 Matching Annotations
  1. Feb 2025
  2. 52.53.155.43 52.53.155.43
    Mitochondrial Transplantation: Adaptive Bio-enhancement
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    AQP1- A regulatory factor associated with brown adipose tissue-silencing
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    52.53.155.43/2dcbfaa0dcc73a4d1082a5a710760ab9fbf9ca77/2024.09.23.614599.full-html.html
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    A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
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    sciencedirect.com/science/article/pii/S1097276525000036
  5. Jan 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11759017/
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    The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models
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    sciencedirect.com/science/article/pii/S2211124724015055
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    A conserved acetylation switch enables pharmacological control of tubby-like protein stability
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    jbc.org/article/S0021-9258(20)00061-7/fulltext
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    Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving
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    nature.com/articles/s41386-024-02030-x
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    HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
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    sciencedirect.com/science/article/pii/S1534580724007330
  12. Dec 2024
  13. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-024-02097-4
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    Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactions
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    biorxiv.org/content/10.1101/2024.12.21.629891v1
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    UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11662662/
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    An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel
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    sciencedirect.com/science/article/pii/S0896627324008778
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and Their Zebrafish Homologs at the Blood-Brain Barrier
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    pmc.ncbi.nlm.nih.gov/articles/PMC11585257/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
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    Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet
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    Proteasome inhibition induces microtubule-dependent changes in nuclear morphology
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  21. pubs.acs.org pubs.acs.org
    Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1
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    Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3
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    Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration
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    Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors
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    science.org/doi/10.1126/sciadv.adp6301
  25. link.springer.com link.springer.com
    Anti-adipogenic activity of oleoresin from Nigella sativa L. seeds via modulation of PPAR-γ and C/EBP-α expression in 3T3-L1 adipocytes
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  26. 52.53.155.43 52.53.155.43
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    Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
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  29. Nov 2024
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KS-cSCC-1 and KS-cSCC-2: two novel cutaneous squamous cell carcinoma cell lines established from Japanese patients
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    Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
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  32. www.science.org www.science.org
    Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors
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    science.org/doi/10.1126/sciadv.adp6301
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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    Degradome analysis to identify direct protein substrates of small-molecule degraders
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β2-integrins control HIF1α activation in human neutrophils
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  36. Oct 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect neurons from cardiac arrest–induced pyroptosis
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  39. Sep 2024
  40. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pharmacologic activation of activating transcription factor 6 contributes to neuronal survival after spinal cord injury in mice
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16092
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    Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing
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    Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
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    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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  48. Aug 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice
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    A genetic basis for sex differences in Xp11 translocation renal cell carcinoma
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    sciencedirect.com/science/article/pii/S2451945624003076
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    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
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    Chinese medicine Linggui Zhugan formula protects against diabetic kidney disease in close association with inhibition of proteinase 3-mediated podocyte apoptosis in mice
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  57. www.authorea.com www.authorea.com
    Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators
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    authorea.com/users/811586/articles/1213019-preliminary-exploration-of-endoplasmic-reticulum-stress-transmission-in-astrocytes-and-neurons-and-its-mediators
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting heme degradation pathway augments prostate cancer cell sensitivity to docetaxel-induced apoptosis and attenuates migration
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    ncbi.nlm.nih.gov/pmc/articles/PMC11291216/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Frontiers | The Nonvesicular Sterol Transporter Aster-C Plays a Minor Role in Whole Body Cholesterol Balance
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
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  61. www.researchsquare.com www.researchsquare.com
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  62. Jul 2024
  63. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
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  64. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies
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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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  67. link.springer.com link.springer.com
    Human neural stem cell secretome relieves endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after traumatic brain injury in a rat model
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    link.springer.com/article/10.1007/s10735-024-10192-7
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223745/
  69. Jun 2024
  70. www.sciencedirect.com www.sciencedirect.com
    Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
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    Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A subpopulation of luminal progenitors secretes pleiotrophin to promote angiogenesis and metastasis in inflammatory breast cancer
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    Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice
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  76. aacrjournals.org aacrjournals.org
    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
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    Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease
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  78. May 2024
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    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
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    KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
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    Ovulation provides excessive coagulation and hepatocyte growth factor signals to cause postoperative intraabdominal adhesions
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    Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage
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    Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
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    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATG9B regulates bacterial internalization via actin rearrangement
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    Increased intestinal bile acid absorption contributes to age-related cognitive impairment
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  91. Apr 2024
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    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome
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    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    SHIP inhibition mediates select TREM2-induced microglial functions
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