596 Matching Annotations
  1. May 2023
  2. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
    1
    1. scibot 05 May 2023
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      DOI: 10.1158/1078-0432.CCR-21-4291

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    aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies
    1
    1. scibot 04 May 2023
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      DOI: 10.3389/fmed.2023.1105894

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    ncbi.nlm.nih.gov/pmc/articles/PMC10151496/
  4. www.science.org www.science.org
    Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release
    1
    1. scibot 04 May 2023
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      DOI: 10.1126/scisignal.abq1366

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    science.org/doi/10.1126/scisignal.abq1366
  5. Apr 2023
  6. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112436

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    sciencedirect.com/science/article/pii/S2211124723004473
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.isci.2023.106639

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    sciencedirect.com/science/article/pii/S2589004223007162
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation
    1
    1. scibot 27 Apr 2023
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      DOI: 10.3389/fnmol.2023.1155047

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    ncbi.nlm.nih.gov/pmc/articles/PMC10118049/
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    ZFP36-mediated mRNA decay regulates metabolism
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112411

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    sciencedirect.com/science/article/pii/S2211124723004229
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    Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice
    1
    1. scibot 26 Apr 2023
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    sciencedirect.com/science/article/pii/S1931312823001464
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.isci.2023.106578

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    sciencedirect.com/science/article/pii/S2589004223006557
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer
    1
    1. scibot 12 Apr 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC9532359/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonged maternal exposure to glucocorticoids alters selenoprotein expression in the developing brain
    1
    1. scibot 12 Apr 2023
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      DOI: 10.3389/fnmol.2023.1115993

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    ncbi.nlm.nih.gov/pmc/articles/PMC10080067/
  14. 52.53.155.43 52.53.155.43
    Evolution of promoter-proximal pausing enabled a new layer of transcription control
    1
    1. scibot 11 Apr 2023
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      DOI: 10.1101/2023.02.19.529146

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    52.53.155.43/3c5d712daefd9b4515c968980af0bacbaf86aeb6/2023.02.19.529146v1.full-html.html
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gain of chromosome 1q perturbs a competitive endogenous RNA network to promote melanoma metastasis
    1
    1. scibot 04 Apr 2023
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      DOI: 10.1158/0008-5472.CAN-22-0283

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    ncbi.nlm.nih.gov/pmc/articles/PMC9971359/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses
    1
    1. scibot 04 Apr 2023
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      DOI: 10.7554/eLife.81577

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    ncbi.nlm.nih.gov/pmc/articles/PMC10065793/
  17. Mar 2023
  18. 52.53.155.43 52.53.155.43
    v1_covered (2)-html.html
    1
    1. scibot 31 Mar 2023
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      DOI: 10.21203/rs.3.rs-2679520/v1

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
    1
    1. scibot 22 Mar 2023
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      DOI: 10.1016/j.isci.2023.106297

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    ncbi.nlm.nih.gov/pmc/articles/PMC10025987/
  20. link.springer.com link.springer.com
    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
    1
    1. scibot 17 Mar 2023
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      DOI: 10.1007/s13402-023-00793-x

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    link.springer.com/article/10.1007/s13402-023-00793-x
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy
    1
    1. scibot 16 Mar 2023
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      DOI: 10.7717/peerj.15049

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    ncbi.nlm.nih.gov/pmc/articles/PMC10010179/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
    1
    1. scibot 05 Mar 2023
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      DOI: 10.1158/0008-5472.CAN-22-0631

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444962/
  23. www.sciencedirect.com www.sciencedirect.com
    Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
    1
    1. scibot 04 Mar 2023
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      DOI: 10.1016/j.cell.2023.02.010

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    sciencedirect.com/science/article/pii/S0092867423001277
  24. Feb 2023
  25. www.mdpi.com www.mdpi.com
    Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment
    1
    1. scibot 23 Feb 2023
      RRID:AB_2242334

      DOI: 10.3390/antiox12020526

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    mdpi.com/2076-3921/12/2/526
  26. www.cell.com www.cell.com
    Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
    1
    1. scibot 16 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112127

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    cell.com/cell-reports/fulltext/S2211-1247(23)00138-9
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    Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix
    1
    1. scibot 11 Feb 2023
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      DOI: 10.1016/j.isci.2023.105965

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    sciencedirect.com/science/article/pii/S2589004223000421
  28. www.sciencedirect.com www.sciencedirect.com
    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
    1
    1. scibot 11 Feb 2023
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      DOI: 10.1016/j.chembiol.2023.01.007

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    sciencedirect.com/science/article/pii/S2451945623000302
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1158/2643-3230.BCD-21-0160

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    ncbi.nlm.nih.gov/pmc/articles/PMC9780084/
  30. Jan 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
    1
    1. scibot 28 Jan 2023
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      DOI: 10.1016/j.celrep.2022.111897

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    sciencedirect.com/science/article/pii/S221112472201796X
  32. www.science.org www.science.org
    Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1126/scisignal.abh1083

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    science.org/doi/10.1126/scisignal.abh1083
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
    1
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      DOI: 10.1016/j.molcel.2022.12.034

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    sciencedirect.com/science/article/pii/S1097276522012175
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    Gasdermin D pore-forming activity is redox-sensitive
    1
    1. scibot 21 Jan 2023
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      DOI: 10.1016/j.celrep.2023.112008

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    sciencedirect.com/science/article/pii/S2211124723000190
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury
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      DOI: 10.4103/1673-5374.357905

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    ncbi.nlm.nih.gov/pmc/articles/PMC9838143/
  36. www.sciencedirect.com www.sciencedirect.com
    PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation
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      DOI: 10.1016/j.isci.2022.105909

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      DOI: 10.1016/j.isci.2022.105909

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    sciencedirect.com/science/article/pii/S2589004222021824
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pan-Cancer Analysis Reveals Recurrent BCAR4 Gene Fusions across Solid Tumors
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      DOI: 10.1158/1541-7786.MCR-21-0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC9530645/
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    METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
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      DOI: 10.1016/j.stem.2022.12.006

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    sciencedirect.com/science/article/pii/S1934590922004908
  39. link.springer.com link.springer.com
    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
    1
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      DOI: 10.1007/s12035-022-03182-x

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  40. Dec 2022
  41. www.sciencedirect.com www.sciencedirect.com
    SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice
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      DOI: 10.1016/j.celrep.2022.111842

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    sciencedirect.com/science/article/pii/S221112472201734X
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    The Agonist of Adenosine A1 Receptor Induced Desensitization of delta Opioid receptor-mediated Raf-1/MEK/ERK Signaling by Feedback Phosphorylation of Raf-1-Ser289/296/301
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      DOI: 10.1007/s11064-022-03843-2

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    link.springer.com/article/10.1007/s11064-022-03843-2
  43. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
    1
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      DOI: 10.1158/2159-8290.CD-21-1491

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    aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
  44. Nov 2022
  45. www.sciencedirect.com www.sciencedirect.com
    circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells
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      DOI: 10.1016/j.celrep.2022.111707

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    sciencedirect.com/science/article/pii/S2211124722015819
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis
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      DOI: 10.1002/glia.24300

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    MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1
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    Expression analyses of polo-like kinase 4 (Plk4), a gene product responsible for autosomal recessive microcephaly and Seckel syndrome, during mouse brain development
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    Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance
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    Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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    TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells
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    Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes
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    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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    Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1)
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    Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
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    Generation and characterization of a genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A)
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    Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization
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    Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET
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    VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
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    Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts
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    Engineering of thick human functional myocardium via static stretching and electrical stimulation
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    5-HT3Rs Maintain Hippocampal LTP in a CB1R-GABAA-Dependent Manner for Spatial Memory
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Emodin inhibits the proliferation and migration of B16F10 cells and induces their apoptosis
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    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
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    Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    Chronic neuronal excitation leads to dual metaplasticity in the signaling for structural long-term potentiation
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  151. Dec 2021
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    PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer
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    Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
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    Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
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    Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation
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    Knockdown of heterogeneous nuclear ribonucleoprotein A1 results in neurite damage, altered stress granule biology and cellular toxicity in differentiated neuronal cells
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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    Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor
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    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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    Beta 2 Adrenergic Receptor Antagonist Propranolol and Opioidergic Receptor Antagonist Naltrexone Produce Synergistic Effects on Breast Cancer Growth Prevention by Acting on Cancer Cells and Immune Environment in a Preclinical Model of Breast Cancer
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    Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity
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    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
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    Pro-inflammatory and proliferative microglia drive progression of glioblastoma
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells
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    Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy
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    Delivery of membrane impermeable molecules to primary mouse T lymphocytes
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
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    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
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  190. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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    Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice
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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Expression and distribution of Trophoblast Glycoprotein in the mouse retina
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    Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Contribute to Neuronal Cell Loss in an Animal Model of Multiple Sclerosis
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  203. Jul 2021
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    Combination of an engineered Lactococcus lactis expressing CXCL12 with light-emitting diode yellow light as a treatment for scalded skin in mice
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    TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells
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      Anti-beta actin [8H10D10], mouse monoclonal

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    Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats
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  209. www.nature.com www.nature.com
    Dominant-negative ATF5 rapidly depletes survivin in tumor cells
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      mouse anti-ACTIN

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    A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
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    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
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    A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication
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    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
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      AB_2242334u00a0

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      u03b2-actin (3700, AB_2242334)

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    Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
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  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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