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    Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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  4. Apr 2024
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    Role of ecto-5′-nucleotidase in bladder function
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    FEBS Press
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    Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity
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    Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
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    Nucleoside-diphosphate kinase of uropathogenic Escherichia coli inhibits caspase-1-dependent pyroptosis facilitating urinary tract infection
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  10. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins
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    Single-cell omics identifies inflammatory signaling as a trans-differentiation trigger in mouse embryos
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    Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis
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    The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury
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    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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    Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice
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    LC3-dependent extracellular vesicles (LDEVs) promote M-MDSC accumulation and immunosuppression in colorectal cancer.
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    Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
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    Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
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    sciencedirect.com/science/article/pii/S0896627324000898
  21. Feb 2024
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    Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety
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    Blood oxygen regulation via P2Y12R expressed in the carotid body
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  24. Jan 2024
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    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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    Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
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  27. Dec 2023
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    Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
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    Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk
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  30. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
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    The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress
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  34. Oct 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
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    LncRNA CFRL aggravates cardiac fibrosis by modulating both miR-3113-5p/CTGF and miR-3473d/FN1 axis
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    Gonacin: A germ cell-derived hormone with glucogenic, orexigenic, and gonadal activities
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    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
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    Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma
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    Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
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  41. Aug 2023
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    A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease
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    P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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  54. Jun 2023
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    Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
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  62. May 2023
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    Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
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  66. Apr 2023
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  68. Mar 2023
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    A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
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    The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/H2S pathway on the carbachol-mediated contraction of mouse bladder smooth muscle
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    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
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    DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma
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  88. Dec 2022
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    Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma
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    Morusin Protected Ruminal Epithelial Cells against Lipopolysaccharide-Induced Inflammation through Inhibiting EGFR-AKT/NF-κB Signaling and Improving Barrier Functions
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  91. Nov 2022
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    Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression
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    Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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    Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition - Cuihong Jia, Chiharu Lovins, Hannah M Malone, Matthew P Keasey, Theo Hagg, 2022
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  113. May 2022
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    Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
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    Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  122. Mar 2022
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
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  134. Jan 2022
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    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
    1
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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  145. Nov 2021
  146. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC1A5 provides glutamine and asparagine necessary for bone development in mice
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  148. www.sciencedirect.com www.sciencedirect.com
    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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      DOI: 10.1016/j.celrep.2021.109926

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    sciencedirect.com/science/article/pii/S2211124721013991
  149. Oct 2021
  150. www.sciencedirect.com www.sciencedirect.com
    Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila
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  151. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways
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      RRID:AB_330288

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  152. www.sciencedirect.com www.sciencedirect.com
    RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination
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      DOI: 10.1016/j.celrep.2021.109824

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  153. www.sciencedirect.com www.sciencedirect.com
    PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
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  154. academic.oup.com academic.oup.com
    LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice
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      DOI: 10.1210/endocr/bqab166

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  155. Sep 2021
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activity and mechanism of acquired resistance to tarloxotinib in HER2 mutant lung cancer: an in vitro study
    1
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      DOI: 10.21037/tlcr-21-216

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  157. www.sciencedirect.com www.sciencedirect.com
    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    1. scibot 22 Sep 2021
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  158. www.sciencedirect.com www.sciencedirect.com
    Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation
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  159. www.sciencedirect.com www.sciencedirect.com
    Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice
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      4967s

      DOI: 10.1016/j.neuint.2021.105177

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  160. www.sciencedirect.com www.sciencedirect.com
    IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
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  161. Aug 2021
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons
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      RRID:AB_330288

      DOI: 10.1016/j.celrep.2021.109551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8422973/
  163. www.sciencedirect.com www.sciencedirect.com
    A light-switching pyrene probe to detect phase separated biomolecules
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    1. scibot 16 Aug 2021
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    sciencedirect.com/science/article/pii/S2589004221008336
  164. www.sciencedirect.com www.sciencedirect.com
    PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites
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    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109510

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    sciencedirect.com/science/article/pii/S2211124721009402
  165. www.tandfonline.com www.tandfonline.com
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      RRID:AB_330288

      DOI: 10.1080/15384047.2018.1504722

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  166. academic.oup.com academic.oup.com
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      AB_330288

      DOI: 10.1210/en.2016-1854

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  167. www.sciencedirect.com www.sciencedirect.com
    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
    1
    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.celrep.2018.10.079

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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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      DOI: 10.1016/j.celrep.2021.109420

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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  171. Jul 2021
  172. academic.oup.com academic.oup.com
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    Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells
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      RRID:AB_330288

      DOI: 10.1016/j.cmet.2019.01.016

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  174. www.nature.com www.nature.com
    Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer
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      β-Actin rabbit antibody

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    nature.com/articles/s41420-019-0218-y
  175. www.nature.com www.nature.com
    Treatment of type 2 diabetes with the designer cytokine IC7Fc
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      β-actin

      DOI: 10.1038/s41586-019-1601-9

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  176. wellcomeopenresearch.org wellcomeopenresearch.org
    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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      β-actin

      DOI: 10.12688/wellcomeopenres.15403.1

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  177. www.sciencedirect.com www.sciencedirect.com
    Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
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  178. www.tandfonline.com www.tandfonline.com
    Caprine herpesvirus 1 (CpHV-1) as a potential candidate for oncolytic virotherapy
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  179. www.sciencedirect.com www.sciencedirect.com
    Androgen receptor is a negative regulator of contextual fear memory in male mice
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      4967S

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  180. elifesciences.org elifesciences.org
    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
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      4967L

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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  182. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early‐life‐stress affects the homeostasis of glutamatergic synapses
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      AB823414

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  183. www.sciencedirect.com www.sciencedirect.com
    Early-life stress induces cognitive disorder in middle-aged mice
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      RRID:AB_823414

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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity
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    1. scibot 27 Jul 2021
      AB_2629465

      DOI: 10.7554/eLife.18207

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  185. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Methyl CpG level at distal part of heat‐shock protein promoter HSP70 exhibits epigenetic memory for heat stress by modulating recruitment of POU2F1‐associated nucleosome‐remodeling deacetylase (NuRD) complex
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      AB_330288

      DOI: 10.1111/jnc.14014

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  186. rupress.org rupress.org
    Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination
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    1. scibot 23 Jul 2021
      4967S

      DOI: 10.1083/jcb.202006043

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  187. www.sciencedirect.com www.sciencedirect.com
    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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      RRID:AB_330288

      DOI: 10.1016/j.cell.2021.06.028

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  188. www.sciencedirect.com www.sciencedirect.com
    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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      RRID:AB_330288

      DOI: 10.1016/j.xcrm.2021.100344

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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression
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    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice
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  193. Jun 2021
  194. www.sciencedirect.com www.sciencedirect.com
    Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin
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    In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine regulates ovarian cancer cell migration and invasion through ETS1
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    Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells
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  198. May 2021
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    hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis
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    Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation
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    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain
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    The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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    DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma
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    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
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    A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation
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  211. Apr 2021
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    Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    Hypothalamic bile acid-TGR5 signaling protects from obesity
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  215. Mar 2021
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    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
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  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Factor
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    Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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    Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
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  222. Feb 2021
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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    Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity
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    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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    Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways
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    SCF‐Slimb is critical for GSK‐3β‐mediated suppression of TAF15‐induced neurotoxicity in Drosophila
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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