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Aug 2025
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Protocol for differentiating murine 3T3-L1 and SVF-derived preadipocytes and isolating crude mitochondrial fractions

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Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.

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1-s2.0-S2589004225015652-main-html.html

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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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Jul 2025
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

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The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression

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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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Jun 2025
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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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PTEN protein phosphatase activity regulates metastasis by targeting PKCδ

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Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease

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May 2025
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Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway

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CapdevilaCastillo_columbia_0054D_18600-html.html

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Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice

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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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Apr 2025
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Integrated pharmacoanalysis, bioinformatics analysis, and experimental validation to identify the ingredients and mechanisms of Xiao-Luo-Wan in uterine fibroids treatment

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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling

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HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance

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Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission

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LNS8801: An Enantiomerically Pure Agonist of the G Protein–Coupled Estrogen Receptor Suitable for Clinical Development

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Glucagon like peptide-1 modulates urinary sodium excretion in diabetic kidney disease via ENaC activation

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Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides

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Mar 2025
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m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

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Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity informing a looping-mediated therapeutic avenue

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Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis

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The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents

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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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cell.com/cell/abstract/S0092-8674(25)00145-X
Feb 2025
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TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms

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  DOI: 10.1016/j.celrep.2024.115113
  
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RNA m5C methylation mediated by Ybx1 ensures hematopoietic stem and progenitor cell expansion

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BPS Publications

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  DOI: 10.1111/bph.17344
  
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Rhodoquinone carries electrons in the mammalian electron transport chain

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  DOI: 10.1016/j.cell.2024.12.007
  
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Jan 2025
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

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Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies

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Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring

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1-s2.0-S2589004225000112-main-html.html

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Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer

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BPS Publications

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dgae876-html.html

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Cell-autonomous action of Slit2 in radial migration of cortical projection neurons

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Inhibition of iron-induced cofilin activation and inflammation in microglia by a novel cofilin inhibitor

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Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

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Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection

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Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys

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Covalent targeting of splicing in T cells

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Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma

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Hyperfunction of AMPA receptors in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice

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SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons

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Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death

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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation

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NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance

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Protocol for CRISPR-Cas12a genome editing of protein tyrosine phosphatases in human pluripotent stem cells and functional β-like cell generation

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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming

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Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma

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A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

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Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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3-Hydroxy-3-Methylglutaric Acid Disrupts Brain Bioenergetics, Redox Homeostasis, and Mitochondrial Dynamics and Affects Neurodevelopment in Neonatal Wistar Rats

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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

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Identification and characterization of TM4SF1+ tumor self-seeded cells

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Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche

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p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization

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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties

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O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability

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MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C

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Adipocyte-Released Adipomes in Chagas Cardiomyopathy: Impact on Cardiac Metabolic and Immune Regulation

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Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals

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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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Role of ecto-5′-nucleotidase in bladder function

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FEBS Press

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Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

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Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma

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Nucleoside-diphosphate kinase of uropathogenic Escherichia coli inhibits caspase-1-dependent pyroptosis facilitating urinary tract infection

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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteins

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Single-cell omics identifies inflammatory signaling as a trans-differentiation trigger in mouse embryos

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Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis

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The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury

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Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

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Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

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LC3-dependent extracellular vesicles (LDEVs) promote M-MDSC accumulation and immunosuppression in colorectal cancer.

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Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

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Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

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Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety

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Blood oxygen regulation via P2Y12R expressed in the carotid body

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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

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Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity

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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk

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Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

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The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress

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Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

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LncRNA CFRL aggravates cardiac fibrosis by modulating both miR-3113-5p/CTGF and miR-3473d/FN1 axis

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Gonacin: A germ cell-derived hormone with glucogenic, orexigenic, and gonadal activities

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Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK

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Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma

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Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes

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A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease

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P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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PIIS2589004223016784-html.html

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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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Supplemental_Material.doc-html.html

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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart

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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

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Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism

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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

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Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

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Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

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Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation

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Inhibition of high-fat diet-induced inflammatory responses in adipose tissue by SF1-expressing neurons of the ventromedial hypothalamus

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The circadian clock is disrupted in pancreatic cancer

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Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma

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Astrotactin2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems

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Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.

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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

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m6A promotes planarian regeneration

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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy

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The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/H2S pathway on the carbachol-mediated contraction of mouse bladder smooth muscle

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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Sulfite Impairs Bioenergetics and Redox Status in Neonatal Rat Brain: Insights into the Early Neuropathophysiology of Isolated Sulfite Oxidase and Molybdenum Cofactor Deficiencies

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Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats

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Dual role of the P2X7 receptor in dendritic outgrowth during physiological and pathological brain development

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Feb 2023
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Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study

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SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron

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Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

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SSRN-id4244248-html.html

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Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

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DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

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Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma

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Morusin Protected Ruminal Epithelial Cells against Lipopolysaccharide-Induced Inflammation through Inhibiting EGFR-AKT/NF-κB Signaling and Improving Barrier Functions

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Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

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The HSF1-CPT1a Pathway Is Differentially Regulated in NAFLD Progression

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SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice

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Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling

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mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading

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BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

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Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma

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A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice

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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

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Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome

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cd-21-0646-html.html

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Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition - Cuihong Jia, Chiharu Lovins, Hannah M Malone, Matthew P Keasey, Theo Hagg, 2022

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Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish

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JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation

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Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom

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Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes

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Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide

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Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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BPS Publications

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Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection

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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

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Mar 2022
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Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat

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Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models

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Familial natural short sleep mutations reduce Alzheimer pathology in mice

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Corticotropin-releasing factor aggravates ischemic stroke injury by the inflammatory activation of microglia

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Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

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Feb 2022
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Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

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PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways

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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

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Female-specific role of ciliary neurotrophic factor in the medial amygdala in promoting stress responses

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Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers

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Jan 2022
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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Dec 2021
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Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

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Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization

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Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway

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Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes

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DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation

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  DOI: 10.1016/j.isci.2021.103436
  
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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis

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