819 Matching Annotations
  1. Apr 2023
  2. www.sciencedirect.com www.sciencedirect.com
    Regulation of sertoli cell function by planar cell polarity (PCP) protein Fjx1
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    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.mce.2023.111936

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    sciencedirect.com/science/article/pii/S0303720723000874
  3. www.hindawi.com www.hindawi.com
    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
    1
    1. scibot 28 Apr 2023
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      DOI: 10.1155/2023/8938674

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    hindawi.com/journals/np/2023/8938674/
  4. www.thelancet.com www.thelancet.com
    Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.ebiom.2023.104569

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    thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00134-2/abstract
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    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.isci.2023.106661

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    sciencedirect.com/science/article/pii/S2589004223007381
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    Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes
    1
    1. scibot 26 Apr 2023
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    sciencedirect.com/science/article/pii/S2211124723004448
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
    1
    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
  8. www.biorxiv.org www.biorxiv.org
    RhoB promotes Salmonella survival by regulating autophagy
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    1. scibot 20 Apr 2023
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      DOI: 10.1101/2023.04.05.535690

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    biorxiv.org/content/10.1101/2023.04.05.535690v1
  9. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
    1
    1. scibot 18 Apr 2023
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      DOI: 10.1038/s41416-023-02264-4

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  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
    1
    1. scibot 09 Apr 2023
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      DOI: 10.7554/eLife.78629

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
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    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1016/j.isci.2023.106495

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    sciencedirect.com/science/article/pii/S2589004223005722
  12. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1002/iub.2722

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    1
    1. scibot 08 Apr 2023
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    sciencedirect.com/science/article/pii/S2666379123001179
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphate Depletion in Insulin-Insensitive Skeletal Muscle Drives AMPD Activation and Sarcopenia in Chronic Kidney DIsease
    1
    1. scibot 05 Apr 2023
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      DOI: 10.1016/j.isci.2023.106355

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    ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
    1
    1. scibot 04 Apr 2023
      RRID:AB_329827

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    ncbi.nlm.nih.gov/pmc/articles/PMC10060068/
  16. Mar 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
    1
    1. scibot 26 Mar 2023
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      DOI: 10.1371/journal.pone.0281063

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation
    1
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.isci.2023.106251

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    ncbi.nlm.nih.gov/pmc/articles/PMC10005909/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
    1
    1. scibot 05 Mar 2023
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      DOI: 10.1158/1541-7786.MCR-22-0090

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
  21. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 03 Mar 2023
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      DOI: 10.1111/bph.16047

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16047
  22. www.science.org www.science.org
    Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
    1
    1. scibot 02 Mar 2023
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      DOI: 10.1126/sciadv.ade2540

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    science.org/doi/10.1126/sciadv.ade2540
  23. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
    1
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      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
    1
    1. scibot 02 Mar 2023
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      DOI: 10.1126/sciadv.ade2540

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    ncbi.nlm.nih.gov/pmc/articles/PMC9946360/
  25. Feb 2023
  26. www.mdpi.com www.mdpi.com
    Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment
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    1. scibot 23 Feb 2023
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      DOI: 10.3390/antiox12020526

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    mdpi.com/2076-3921/12/2/526
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1126/scisignal.abj5879

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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  28. www.sciencedirect.com www.sciencedirect.com
    Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle
    1
    1. scibot 16 Feb 2023
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      DOI: 10.1016/j.ygcen.2023.114231

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    sciencedirect.com/science/article/pii/S0016648023000369
  29. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    1. scibot 16 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.007

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    sciencedirect.com/science/article/pii/S1535610823000077
  30. www.nature.com www.nature.com
    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
    1
    1. scibot 15 Feb 2023
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      DOI: 10.1038/s41420-023-01359-4

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    nature.com/articles/s41420-023-01359-4
  31. 52.53.155.43 52.53.155.43
    bcd-22-0082-html.html
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      DOI: 10.1158/2643-3230.BCD-22-0082

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
    1
    1. scibot 10 Feb 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC9887205/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer
    1
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      DOI: 10.1158/1541-7786.MCR-21-0994

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357101/
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    An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
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      DOI: 10.1016/j.chembiol.2023.01.003

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    sciencedirect.com/science/article/pii/S2451945623000260
  35. Jan 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development
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      DOI: 10.1016/j.immuni.2022.11.013

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    sciencedirect.com/science/article/pii/S1074761322006033
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    Multi-omics profiling visualizes dynamics of cardiac development and functions
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    sciencedirect.com/science/article/pii/S2211124722017909
  38. academic.oup.com academic.oup.com
    Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice
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    academic.oup.com/endo/article/164/3/bqac214/6969391
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    sciencedirect.com/science/article/pii/S2211124722018654
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect
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    ncbi.nlm.nih.gov/pmc/articles/PMC9838174/
  41. f1000research.com f1000research.com
    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    f1000research.com/articles/11-1563
  42. www.sciencedirect.com www.sciencedirect.com
    Glutamine and leucine administration attenuates muscle atrophy in sepsis
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    sciencedirect.com/science/article/pii/S002432052201027X
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
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    The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  134. aacrjournals.org aacrjournals.org
    δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice
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  135. Mar 2022
  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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  137. asbmr.onlinelibrary.wiley.com asbmr.onlinelibrary.wiley.com
    Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice
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    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
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  141. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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  143. www.sciencedirect.com www.sciencedirect.com
    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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  145. Feb 2022
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    Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
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    Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion
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  149. www.sciencedirect.com www.sciencedirect.com
    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
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    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway
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  156. link.springer.com link.springer.com
    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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  157. Jan 2022
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACE2 pathway regulates thermogenesis and energy metabolism
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  159. www.sciencedirect.com www.sciencedirect.com
    Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2
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    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    The portrait of liver cancer is shaped by mitochondrial genetics
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  163. Dec 2021
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes
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  167. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  168. journals.sagepub.com journals.sagepub.com
    Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  171. Nov 2021
  172. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  173. 52.53.155.43 52.53.155.43
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