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  2. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    1. scibot 18 Apr 2024
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      DOI: 10.1002/path.6282

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  3. Apr 2024
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    link.springer.com/article/10.1007/s12035-024-04171-y
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    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
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    sciencedirect.com/science/article/pii/S2666979X24000934
  6. 52.53.155.43 52.53.155.43
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1
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    1. scibot 10 Apr 2024
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      DOI: 10.7554/eLife.96891

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    ncbi.nlm.nih.gov/pmc/articles/PMC11001299/
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  9. Mar 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
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    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    Prolactin promotes the recruitment of main olfactory bulb cells and enhances the behavioral exploration toward a socio-sexual stimulus in female mice
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    sciencedirect.com/science/article/pii/S0018506X24000527
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    Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells
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    1. scibot 17 Mar 2024
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      DOI: 10.7554/eLife.91903

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942591/
  14. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    1. scibot 27 Feb 2024
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    sciencedirect.com/science/article/pii/S2589004224003420
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    Sphingolipid metabolism controls mammalian heart regeneration
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    1. scibot 21 Feb 2024
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    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
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    1. scibot 08 Feb 2024
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    A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin-treated rats
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    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S0092867424000060
  20. Jan 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
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    Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner
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    sciencedirect.com/science/article/pii/S1534580723006913
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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  24. 52.53.155.43 52.53.155.43
    bqae003-html.html
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      DOI: 10.1210/endocr/bqae003

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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    1. scibot 05 Jan 2024
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      DOI: 10.1158/1535-7163.MCT-23-0026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
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    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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      DOI: 10.1152/ajpregu.00274.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  27. Dec 2023
  28. www.sciencedirect.com www.sciencedirect.com
    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    sciencedirect.com/science/article/pii/S2589004223026457
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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      DOI: 10.1016/j.xcrm.2023.101341

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    sciencedirect.com/science/article/pii/S266637912300558X
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    An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling
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    sciencedirect.com/science/article/pii/S0092867423012266
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  33. Nov 2023
  34. www.sciencedirect.com www.sciencedirect.com
    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    sciencedirect.com/science/article/pii/S2211124723013864
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    Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway
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      DOI: 10.1016/j.heliyon.2023.e22800

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    sciencedirect.com/science/article/pii/S2405844023100089
  36. Oct 2023
  37. 52.53.155.43 52.53.155.43
    bqad159-html.html
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  38. dx.doi.org dx.doi.org
    Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice
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      DOI: 10.1210/endocr/bqad151

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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  40. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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      DOI: 10.1126/sciadv.abo3610

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  41. 52.53.155.43 52.53.155.43
    ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    sciencedirect.com/science/article/pii/S2211124723012147
  44. Sep 2023
  45. 52.53.155.43 52.53.155.43
    Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess
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  46. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overfit deep neural network for predicting drug–target interactions
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  49. Aug 2023
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    RhoB Promotes Salmonella survival by Regulating Autophagy
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    Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation
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    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    Proteogenomic insights suggest druggable pathways in endometrial carcinoma
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
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    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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  69. Jun 2023
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    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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  78. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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  88. Apr 2023
  89. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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    Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
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    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development
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    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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  184. Feb 2022
  185. www.sciencedirect.com www.sciencedirect.com
    Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  192. Jan 2022
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    Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis
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    Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes
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    PI3K inhibition by BKM120 results in anti-proliferative effects on corticotroph tumor cells
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  196. Dec 2021
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    RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
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    Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner
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    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  212. Oct 2021
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    Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction
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    The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and alters neuronal function at the cellular and network levels
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    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
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  217. Sep 2021
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    Activity and mechanism of acquired resistance to tarloxotinib in HER2 mutant lung cancer: an in vitro study
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    Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health
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    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
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    Cilium induction triggers differentiation of glioma stem cells
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    C1q/tumor necrosis factor-related protein-3 improves microvascular endothelial function in diabetes through the AMPK/eNOS/NO· signaling pathway
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