1,484 Matching Annotations
  1. Jun 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12157921/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147664/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Translation suppresses exogenous target RNA-mediated microRNA decay
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    pmc.ncbi.nlm.nih.gov/articles/PMC12144122/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12155759/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12145039/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK1-mediated phosphorylation of USP37 regulates SND1 stability and promotes oncogenesis in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12138069/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3
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    pmc.ncbi.nlm.nih.gov/articles/PMC12145718/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162027/
  11. 52.53.155.43 52.53.155.43
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    52.53.155.43/9a2f79631a0beb40aa09f744c00e5a575573d112/PDF-html.html
  12. www.embopress.org www.embopress.org
    Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer
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    embopress.org/doi/10.1038/s44321-025-00254-y
  13. elifesciences.org elifesciences.org
    A Commander-independent function of COMMD3 in endosomal trafficking
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    elifesciences.org/reviewed-preprints/105264
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic mapping of the human solute carrier superfamily
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130231/
  15. www.sciencedirect.com www.sciencedirect.com
    Synaptic activity causes minute-scale changes in BAF complex composition and function
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    sciencedirect.com/science/article/pii/S1097276525004563
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12123483/
  17. www.sciencedirect.com www.sciencedirect.com
    Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
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    sciencedirect.com/science/article/pii/S0092867425005562
  18. May 2025
  19. elifesciences.org elifesciences.org
    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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    elifesciences.org/reviewed-preprints/101984
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APOBEC3 Activity Promotes the Survival and Evolution of Drug-Tolerant Persister Cells during EGFR Inhibitor Resistance in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093302/
  21. www.sciencedirect.com www.sciencedirect.com
    IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma
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    sciencedirect.com/science/article/pii/S2589004225008284
  22. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway
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    sciencedirect.com/science/article/pii/S2211124725005042
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Expanding the bat toolbox: Carollia perspicillata bat cell lines and reagents enable the characterization of viral susceptibility and innate immune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11999112/
  25. 52.53.155.43 52.53.155.43
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    52.53.155.43/0976643c3f79ff08c8e38df9c7b0ed5aea42f921/PDF-html.html
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reversible downregulation of HLA class I in adenoid cystic carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010351/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077180/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NEMO is essential for directing the kinases IKKα and ATM to the sites of DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070652/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017300/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11572484/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12067245/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12037013/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p97/VCP is required for piecemeal autophagy of aggresomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059050/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075652/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022042/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048556/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12055005/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug target
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    pmc.ncbi.nlm.nih.gov/articles/PMC12080387/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System
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    pmc.ncbi.nlm.nih.gov/articles/PMC12029788/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12027498/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALDH1A3 Regulates Cellular Senescence and Senescence-Associated Secretome in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11987895/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021886/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12054253/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12040169/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gas1-high quiescent neural stem cells are multipotent and produce oligodendrocytes during aging and after demyelinating injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11990765/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of placental trophoblast fusion by guanylate-binding protein 5
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    pmc.ncbi.nlm.nih.gov/articles/PMC12057675/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12034038/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069520/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Feedback-responsive cell factories for dynamic modulation of the unfolded protein response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048557/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12062253/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056021/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12041315/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12045962/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Congenital enteropathy caused by ezrin deficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12033192/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non‐Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077270/
  57. 52.53.155.43 52.53.155.43
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    52.53.155.43/581690a87db32a6cd802c9bdccaa776024adf4bf/PDF-html.html
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024519/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002136/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022045/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997214/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide screen identifies genes required for erythroid differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11993733/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF6α inhibits ΔNp63α expression to promote breast cancer metastasis by the GRP78-AKT1-FOXO3a signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994819/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12009364/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997380/
  67. www.sciencedirect.com www.sciencedirect.com
    Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
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    sciencedirect.com/science/article/pii/S2211124725004280
  68. www.sciencedirect.com www.sciencedirect.com
    ERBB4 selectively amplifies TGF-β pro-metastatic responses
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    sciencedirect.com/science/article/pii/S2211124724015614
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lineage-specific CDK activity dynamics characterize early mammalian development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070373/
  70. Apr 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013414/
  72. www.sciencedirect.com www.sciencedirect.com
    Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses
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    sciencedirect.com/science/article/pii/S1097276525003053
  73. elifesciences.org elifesciences.org
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    elifesciences.org/reviewed-preprints/106492
  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
  75. www.sciencedirect.com www.sciencedirect.com
    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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    sciencedirect.com/science/article/pii/S109727652500303X
  76. www.sciencedirect.com www.sciencedirect.com
    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    sciencedirect.com/science/article/pii/S153561082500128X
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952453/
  78. 52.53.155.43 52.53.155.43
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    Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance
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    sciencedirect.com/science/article/pii/S1535610825001321
  80. www.nature.com www.nature.com
    Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling
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    nature.com/articles/s41594-025-01522-8
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006248-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951516/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11931876/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest
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    pmc.ncbi.nlm.nih.gov/articles/PMC11934320/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    G0S2 modulates normal vitreous-induced proliferation in endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11971441/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11947120/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11929817/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic OASL expression licenses interferon induction during influenza A virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11956916/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
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  105. Mar 2025
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  126. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  128. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  131. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  132. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  135. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  138. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  139. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  142. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  144. www.nature.com www.nature.com
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  145. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  147. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  148. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  149. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  150. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  153. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  154. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  159. Feb 2025
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  163. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  164. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  165. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  166. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  169. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  170. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  171. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  172. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  173. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  174. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  175. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  176. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  177. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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