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Jul 2025
elifesciences.org elifesciences.org

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

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1. scibot 08 Jul 2025
  
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  RRID:Addgene_52961
  
  DOI: 10.7554/eLife.101984
  
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elifesciences.org/articles/101984
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Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer

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  Addgene_52961
  
  DOI: 10.1158/2159-8290.CD-24-1378
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223508/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225013203-main-html.html

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  Addgene_52961
  
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52.53.155.43/cf5e79d9430fe2c0516d8255d5ed63fff73c6faf/1-s2.0-S2589004225013203-main-html.html
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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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1. scibot 04 Jul 2025
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/0008-5472.CAN-23-3256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
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Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity

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1. scibot 04 Jul 2025
  
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  DOI: 10.1038/s41467-025-60745-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12216399/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

Blood group O expression in normal tissues and tumors

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1. scibot 03 Jul 2025
  
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  plasmid_52961
  
  DOI: 10.1111/febs.70172
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70172
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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sciencedirect.com/science/article/pii/S2666379125002848
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Potassium/sodium cation carriers robustly upregulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells

2
1. scibot 02 Jul 2025
  
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  Addgene_52961
  
  DOI: 10.3324/haematol.2024.285826
  
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  RRID:Addgene_52961
  
  DOI: 10.3324/haematol.2024.285826
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12208165/
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Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastoma

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1. scibot 01 Jul 2025
  
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  DOI: 10.1101/2025.06.18.660339
  
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biorxiv.org/content/10.1101/2025.06.18.660339v1
Jun 2025
www.nature.com www.nature.com

Mechanism of cytarabine-induced neurotoxicity

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1. scibot 28 Jun 2025
  
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  Addgene, 52961
  
  DOI: 10.1038/s41586-025-09210-9
  
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nature.com/articles/s41586-025-09210-9
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A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer

1
1. scibot 28 Jun 2025
  
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  plasmid_52961
  
  DOI: 10.1016/j.ebiom.2025.105828
  
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sciencedirect.com/science/article/pii/S2352396425002725
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

1
1. scibot 28 Jun 2025
  
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  Plasmid_52961
  
  DOI: 10.1016/j.celrep.2025.115921
  
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sciencedirect.com/science/article/pii/S2211124725006928
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RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation

1
1. scibot 26 Jun 2025
  
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  AddgeneCat#52961
  
  DOI: 10.1016/j.cmet.2025.05.014
  
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sciencedirect.com/science/article/pii/S1550413125002943
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PDF-html.html

1
1. scibot 22 Jun 2025
  
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  Addgene_52961
  
  DOI: 10.1016/j.isci.2025.112925
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12270665/
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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

1
1. scibot 21 Jun 2025
  
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  AddgeneCat#: 52961
  
  DOI: 10.1016/j.cmet.2025.05.013
  
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sciencedirect.com/science/article/pii/S1550413125002694
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Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target

1
1. scibot 15 Jun 2025
  
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  52961
  
  DOI: 10.3389/fonc.2025.1572040
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12162274/
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METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through m6A-YTHDF2-pluripotency/Gstp1 mRNA degradation axis

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1. scibot 15 Jun 2025
  
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  52961
  
  DOI: 10.1186/s13619-025-00241-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12116966/
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TRIM29 upregulation contributes to chemoresistance in triple negative breast cancer via modulating S100P-β-catenin axis

1
1. scibot 15 Jun 2025
  
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  lentiCRISPRv2
  
  DOI: 10.1186/s12964-025-02233-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12107940/
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Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling

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1. scibot 15 Jun 2025
  
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  52961
  
  DOI: 10.1126/sciadv.adv4725
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12101510/
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Bat organoids reveal antiviral responses at epithelial surfaces

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1. scibot 15 Jun 2025
  
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  DOI: 10.1038/s41590-025-02155-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12133567/
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Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

1
1. scibot 15 Jun 2025
  
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  LentiCRISPR v2
  
  DOI: 10.1038/s41467-025-60293-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12134272/
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ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

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  DOI: 10.1038/s41467-025-60286-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12119886/
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Linker-free PROTACs efficiently induce the degradation of oncoproteins

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  52961
  
  DOI: 10.1038/s41467-025-60107-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12102262/
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PRL3-zumab as an anti-angiogenic therapy in neovascular eye diseases

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  52961
  
  DOI: 10.1038/s41467-025-59929-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12102187/
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Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

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  52961
  
  DOI: 10.1038/s41467-025-59381-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092585/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for in vivo CRISPR knockout screening of autophagy genes to identify breast cancer metastasis suppressors

1
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  52961
  
  DOI: 10.1016/j.xpro.2025.103798
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12084073/
52.53.155.43 52.53.155.43

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function

2
1. scibot 15 Jun 2025
  
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  Addgene #52961
  
  DOI: 10.1016/j.isci.2024.111518
  
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  Addgene_52961
  
  DOI: 10.1016/j.isci.2024.111518
  
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52.53.155.43/bb3fc3d48d1d1a3ea4bd88205a0b31e5070fc2a9/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapy

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  Addgene_52961
  
  DOI: 10.1038/s41467-025-59977-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12098835/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer

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  plasmid_52961
  
  DOI: 10.1038/s41419-025-07711-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12104440/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells

1
1. scibot 14 Jun 2025
  
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  lentiCRISPR V2
  
  DOI: 10.1371/journal.ppat.1013211
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12157921/
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Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

1
1. scibot 14 Jun 2025
  
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  52961
  
  DOI: 10.1083/jcb.202405061
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147664/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Translation suppresses exogenous target RNA-mediated microRNA decay

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  52961
  
  DOI: 10.1038/s41467-025-60374-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12144122/
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SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

1
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  52961
  
  DOI: 10.1038/s41467-025-60329-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
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WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells

1
1. scibot 14 Jun 2025
  
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  lentiCRISPR v2-Puro
  
  DOI: 10.1016/j.jbc.2025.108528
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12155759/
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Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy

1
1. scibot 14 Jun 2025
  
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  lentiCRISPR V2
  
  DOI: 10.1016/j.apsb.2025.03.014
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12145039/
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CDK1-mediated phosphorylation of USP37 regulates SND1 stability and promotes oncogenesis in colorectal cancer

1
1. scibot 14 Jun 2025
  
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  LentiCRISPR v2
  
  DOI: 10.1016/j.apsb.2025.02.014
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12138069/
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Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3

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Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping

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Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer

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A Commander-independent function of COMMD3 in endosomal trafficking

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Metabolic mapping of the human solute carrier superfamily

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Synaptic activity causes minute-scale changes in BAF complex composition and function

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P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids

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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

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The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

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APOBEC3 Activity Promotes the Survival and Evolution of Drug-Tolerant Persister Cells during EGFR Inhibitor Resistance in Lung Cancer

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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

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Expanding the bat toolbox: Carollia perspicillata bat cell lines and reagents enable the characterization of viral susceptibility and innate immune responses

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Reversible downregulation of HLA class I in adenoid cystic carcinoma

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RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles

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  plasmid_52961
  
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NEMO is essential for directing the kinases IKKα and ATM to the sites of DNA damage

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  plasmid_52961
  
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In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancer

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MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

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Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells

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  plasmid_52961
  
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Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia

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p97/VCP is required for piecemeal autophagy of aggresomes

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  Addgene_52961
  
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ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213

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TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases

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LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

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The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

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Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug target

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pmc.ncbi.nlm.nih.gov/articles/PMC12080387/
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High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System

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The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration

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ALDH1A3 Regulates Cellular Senescence and Senescence-Associated Secretome in Prostate Cancer

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  lentiCRISPRv2
  
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Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

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RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response

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  lentiCRISPRv2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12054253/
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A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia

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pmc.ncbi.nlm.nih.gov/articles/PMC12040169/
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Gas1-high quiescent neural stem cells are multipotent and produce oligodendrocytes during aging and after demyelinating injury

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  pLentiCRISPR V2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11990765/
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LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma

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  52961
  
  DOI: 10.1158/2159-8290.CD-24-1317
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
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Inhibition of placental trophoblast fusion by guanylate-binding protein 5

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1126/sciadv.adt5388
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12057675/
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DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis

1
1. scibot 17 May 2025
  
  in Public
  
  52961
  
  DOI: 10.1093/nar/gkaf319
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12034038/
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Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium

1
1. scibot 17 May 2025
  
  in Public
  
  lentiCRISPRv2
  
  DOI: 10.1038/s42003-025-08183-9
  
  Resource: RRID:Addgene_52961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12069520/
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Feedback-responsive cell factories for dynamic modulation of the unfolded protein response

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-58994-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048557/
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Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-58552-5
  
  Resource: RRID:Addgene_52961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12062253/
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PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1038/s41419-025-07690-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12056021/
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UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1038/s41419-025-07532-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12041315/
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NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1038/s12276-025-01430-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12045962/
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Congenital enteropathy caused by ezrin deficiency

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1007/s00439-025-02738-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12033192/
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Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non‐Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning

1
1. scibot 17 May 2025
  
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  52961
  
  DOI: 10.1002/jev2.70078
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12077270/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 16 May 2025
  
  in Public
  
  Addgene plasmid Cat. #: 52961
  
  DOI: 10.1158/2326-6066.cir-24-0127
  
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52.53.155.43/581690a87db32a6cd802c9bdccaa776024adf4bf/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1126/sciadv.ads6385
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12024519/
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Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1126/sciadv.ado7660
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12002136/
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The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-59309-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12022045/
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Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-58740-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997214/
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A genome-wide screen identifies genes required for erythroid differentiation

2
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-58739-w
  
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  RRID:Addgene_52961
2. scibot 16 May 2025
  
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  pLentiCRISPRv2
  
  DOI: 10.1038/s41467-025-58739-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11993733/
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An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41467-025-58619-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
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ATF6α inhibits ΔNp63α expression to promote breast cancer metastasis by the GRP78-AKT1-FOXO3a signaling

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41419-025-07619-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11994819/
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Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1038/s41419-025-07617-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12009364/
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Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94

1
1. scibot 16 May 2025
  
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  52961
  
  DOI: 10.1016/j.jbc.2025.108369
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997380/
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Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

1
1. scibot 16 May 2025
  
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  Addgene#52961
  
  DOI: 10.1016/j.celrep.2025.115657
  
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sciencedirect.com/science/article/pii/S2211124725004280
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ERBB4 selectively amplifies TGF-β pro-metastatic responses

1
1. scibot 16 May 2025
  
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.celrep.2024.115210
  
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sciencedirect.com/science/article/pii/S2211124724015614
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Lineage-specific CDK activity dynamics characterize early mammalian development

1
1. scibot 16 May 2025
  
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  Addgene_52961
  
  DOI: 10.1016/j.celrep.2025.115558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12070373/
Apr 2025
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Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

1
1. scibot 24 Apr 2025
  
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  lentiCRISPRv2 (52961
  
  DOI: 10.1080/15548627.2024.2443300
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12013414/
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Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

1
1. scibot 24 Apr 2025
  
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  Addgene 52961
  
  DOI: 10.1016/j.molcel.2025.04.002
  
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sciencedirect.com/science/article/pii/S1097276525003053
elifesciences.org elifesciences.org

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

1
1. scibot 24 Apr 2025
  
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  plasmid_52961
  
  DOI: 10.7554/eLife.106492.1
  
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elifesciences.org/reviewed-preprints/106492
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 19 Apr 2025
  
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  52961; Addgene
  
  DOI: 10.1111/febs.70099
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
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The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin

1
1. scibot 19 Apr 2025
  
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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2025.03.026
  
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sciencedirect.com/science/article/pii/S109727652500303X
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
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  Addgene_52961
  
  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

1
1. scibot 18 Apr 2025
  
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  plasmid_52961
  
  DOI: 10.1101/2025.03.10.642426
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952453/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 13 Apr 2025
  
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  Addgene_52961
  
  DOI: 10.1101/2025.04.04.647324
  
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52.53.155.43/4c68cb20c96f9831d654e32b29866141bc56f76e/PDF-html.html
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

1
1. scibot 11 Apr 2025
  
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.ccell.2025.03.031
  
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sciencedirect.com/science/article/pii/S1535610825001321
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Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling

1
1. scibot 10 Apr 2025
  
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  Addgene, cat. no. 52961
  
  DOI: 10.1038/s41594-025-01522-8
  
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nature.com/articles/s41594-025-01522-8
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1-s2.0-S2589004225006248-main-html.html

1
1. scibot 10 Apr 2025
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.isci.2025.112363
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
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A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression

1
1. scibot 07 Apr 2025
  
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  52961
  
  DOI: 10.1186/s40164-025-00626-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11951516/
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Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling

1
1. scibot 07 Apr 2025
  
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  lenti-Rv2
  
  DOI: 10.1186/s12885-025-13881-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11931876/
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Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest

1
1. scibot 07 Apr 2025
  
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  pLentiCRISPRv2
  
  DOI: 10.1128/msphere.00692-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11934320/
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G0S2 modulates normal vitreous-induced proliferation in endothelial cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11971441/
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Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression

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pmc.ncbi.nlm.nih.gov/articles/PMC11947120/
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LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes

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pmc.ncbi.nlm.nih.gov/articles/PMC11929817/
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Intrinsic OASL expression licenses interferon induction during influenza A virus infection

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pmc.ncbi.nlm.nih.gov/articles/PMC11956916/
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KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
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Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo

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pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
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A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine

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pmc.ncbi.nlm.nih.gov/articles/PMC11933316/
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Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma

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pmc.ncbi.nlm.nih.gov/articles/PMC11968822/
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Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs

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pmc.ncbi.nlm.nih.gov/articles/PMC11926384/
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Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene Zeste White 10 in Hepatocellular Carcinoma

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  lentiCRISPRv2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11954606/
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Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion

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pmc.ncbi.nlm.nih.gov/articles/PMC11955114/
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Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy

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pmc.ncbi.nlm.nih.gov/articles/PMC11954966/
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Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance

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pmc.ncbi.nlm.nih.gov/articles/PMC11966756/
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A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11965687/
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The impact of a high fat diet and platelet activation on pre-metastatic niche formation

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pmc.ncbi.nlm.nih.gov/articles/PMC11965330/
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Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction

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pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
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NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

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biorxiv.org/content/10.1101/2025.03.29.646096v1
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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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sciencedirect.com/science/article/pii/S2211124725002232
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Dicer deficiency affects microglial function during demyelination and impairs remyelination

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sciencedirect.com/science/article/pii/S0969996125000956
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Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

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sciencedirect.com/science/article/pii/S2666379125001119
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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

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sciencedirect.com/science/article/pii/S1097276525001947
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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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Knocking out Arl13b completely abolishes primary ciliogenesis

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biorxiv.org/content/10.1101/2025.03.17.643595v1
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Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

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A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11900931/
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The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor

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  lentiCRISPRv2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11899812/
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Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis

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pmc.ncbi.nlm.nih.gov/articles/PMC11912599/
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Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4

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  DOI: 10.1186/s12929-025-01129-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11912690/
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Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway

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  DOI: 10.1186/s10020-025-01141-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11907909/
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RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens

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  DOI: 10.1128/jvi.02008-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915864/
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STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein

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  plentiCRISPRv2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915848/
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Ectopic expression of testis-specific transcription elongation factor in driving cancer

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  DOI: 10.1126/sciadv.ads4200
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908497/
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

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  DOI: 10.1093/narcan/zcaf009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11923746/
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FABP4 as a therapeutic host target controlling SARS-CoV-2 infection

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  DOI: 10.1038/s44321-024-00188-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11904229/
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Comprehensive genomic dependency landscape of a human colon cancer organoid

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pmc.ncbi.nlm.nih.gov/articles/PMC11906589/
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A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

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  DOI: 10.1038/s41421-025-00774-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11894195/
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Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11914223/
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Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1

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  Addgene_52961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898276/
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Single-cell delineation of strain-specific HIV-1 Vif activities using dual reporter sensor cells and live cell imaging

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  plasmid_52961
  
  DOI: 10.1128/jvi.01579-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915839/
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Succinate dehydrogenase activity supports de novo purine synthesis

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  Plasmid_52961
  
  DOI: 10.1101/2025.02.26.640389
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888382/
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Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles

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  plasmid_52961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11919600/
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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

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  AddgeneCat# 52961
  
  DOI: 10.1016/j.cmet.2025.02.008
  
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sciencedirect.com/science/article/pii/S155041312500066X
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MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers

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  plasmid_52961
  
  DOI: 10.1038/s41467-025-57758-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914251/
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The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

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1. scibot 13 Mar 2025
  
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  RRID:Addgene_52961
  
  DOI: 10.1167/iovs.66.3.16
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11895853/
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KSHV hijacks the antiviral kinase IKKε to initiate lytic replication

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  DOI: 10.1371/journal.ppat.1012856
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11781660/
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A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

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  DOI: 10.1371/journal.ppat.1012571
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11856660/
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Regulation of CXCR4 function by S1P1 through heteromerization

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  DOI: 10.1186/s12964-025-02099-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11863771/
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MicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth

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  52961
  
  DOI: 10.1186/s12935-025-03711-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11869434/
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Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection

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  52961
  
  DOI: 10.1128/jvi.01026-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11852722/
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Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci

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  52961
  
  DOI: 10.1101/2025.02.20.639228
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870499/
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CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation

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  52961
  
  DOI: 10.1101/2025.02.11.637707
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844498/
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Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex

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  52961
  
  DOI: 10.1101/2025.02.07.636951
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11839100/
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Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

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  52961
  
  DOI: 10.1101/2025.02.06.636906
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11839035/
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The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells

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  52961
  
  DOI: 10.1093/nar/gkaf093
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850227/
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OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

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  52961
  
  DOI: 10.1038/s44319-024-00361-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
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The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

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  52961
  
  DOI: 10.1038/s44319-024-00339-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850942/
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Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation

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  52961
  
  DOI: 10.1038/s42255-024-01201-w
  
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nature.com/articles/s42255-024-01201-w
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

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  52961
  
  DOI: 10.1038/s41586-024-08532-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
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Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus

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  DOI: 10.1038/s41467-025-57373-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876664/
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HBV-associated hepatocellular carcinomas inhibit antitumor CD8+ T cell via the long noncoding RNA HDAC2-AS2

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  lentiCRISPRv2
  
  DOI: 10.1038/s41467-025-57367-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11871238/
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Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells

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  52961
  
  DOI: 10.1038/s41467-025-57351-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11873286/
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Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development

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  104371
  
  DOI: 10.1038/s41467-025-57165-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11847947/
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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

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  52961
  
  DOI: 10.1038/s41467-025-56130-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
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TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

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  DOI: 10.1038/s41421-024-00766-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
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FTO deficiency facilitates epithelia dysfunction in oral lichen planus

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  52961
  
  DOI: 10.1016/j.omtn.2025.102463
  
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  RRID:Addgene_52961 DOI:10.1016/j.omtn.2025.102463
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pmc.ncbi.nlm.nih.gov/articles/PMC11847738/
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CHIP protects lysosomes from CLN4 mutant-induced membrane damages

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  Addgene_52961
  
  DOI: 10.1101/2025.02.18.638932
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870535/
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Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2

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  Plasmid_52961
  
  DOI: 10.1038/s41598-025-91559-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876635/
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Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

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  plasmid_52961
  
  DOI: 10.1038/s41590-025-02088-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876074/
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Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II

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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2025.02.006
  
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sciencedirect.com/science/article/pii/S109727652500111X
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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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  plasmid_52961
  
  DOI: 10.1016/j.celrep.2025.115397
  
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sciencedirect.com/science/article/pii/S2211124725001688
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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  RRID:Addgene_52961
  
  DOI: 10.1016/j.immuni.2025.02.007
  
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sciencedirect.com/science/article/pii/S107476132500072X
Feb 2025
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Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D

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  plasmid_52961
  
  DOI: 10.1128/jvi.01230-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11852847/
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.celrep.2025.115340
  
  Resource: RRID:Addgene_52961
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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sciencedirect.com/science/article/pii/S2211124725001111
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus

1
1. scibot 24 Feb 2025
  
  in Public
  
  lentiCRISPRv2
  
  DOI: 10.1080/19768354.2025.2465325
  
  Resource: RRID:Addgene_52961
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11834782/
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Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity

1
1. scibot 24 Feb 2025
  
  in Public
  
  52961
  
  DOI: 10.1038/s41467-025-56894-8
  
  Resource: RRID:Addgene_52961
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11830767/
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PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

1
1. scibot 23 Feb 2025
  
  in Public
  
  52961
  
  DOI: 10.1084/jem.20241184
  
  Resource: RRID:Addgene_52961
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11837972/
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

1
1. scibot 23 Feb 2025
  
  in Public
  
  Addgene_52961
  
  DOI: 10.1101/2025.01.26.634889
  
  Resource: RRID:Addgene_52961
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

1
1. scibot 23 Feb 2025
  
  in Public
  
  plasmid_52961101
  
  DOI: 10.1038/s41467-025-56772-3
  
  Resource: None
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRIDCUR:Unresolved RRIDCUR:Incorrect RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11836288/
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A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions

1
1. scibot 21 Feb 2025
  
  in Public
  
  Addgene_52961
  
  DOI: 10.1016/j.celrep.2025.115346
  
  Resource: RRID:Addgene_52961
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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sciencedirect.com/science/article/pii/S2211124725001172
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mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:Addgene_52961
  
  DOI: 10.1016/j.canlet.2025.217565
  
  Resource: RRID:Addgene_52961
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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sciencedirect.com/science/article/pii/S0304383525001296
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FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy

1
1. scibot 18 Feb 2025
  
  in Public
  
  52961
  
  DOI: 10.1038/s41467-025-56633-z
  
  Resource: RRID:Addgene_52961
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11788441/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche

1
1. scibot 18 Feb 2025
  
  in Public
  
  lentiCRISPR v2
  
  DOI: 10.1038/s41467-025-56347-2
  
  Resource: RRID:Addgene_52961
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11799300/
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Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

1
1. scibot 18 Feb 2025
  
  in Public
  
  Addgene_52961
  
  DOI: 10.1371/journal.ppat.1012918
  
  Resource: RRID:Addgene_52961
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11801639/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer

1
1. scibot 18 Feb 2025
  
  in Public
  
  Addgene_52961
  
  DOI: 10.1038/s42003-024-07413-w
  
  Resource: RRID:Addgene_52961
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_52961
  
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  RRID:Addgene_52961
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pmc.ncbi.nlm.nih.gov/articles/PMC11794516/

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