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Aug 2024
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SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

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1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114536
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
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SMYD5 is a regulator of the mild hypothermia response

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ncbi.nlm.nih.gov/pmc/articles/PMC11401508/
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Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs

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1. scibot 17 Aug 2024
  
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  DOI: 10.1038/s41551-024-01204-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310080/
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Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

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1. scibot 17 Aug 2024
  
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  DOI: 10.1002/advs.202309004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11321652/
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A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

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1. scibot 13 Aug 2024
  
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  DOI: 10.1038/s43018-024-00740-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11286358/
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2024.04.26.591029v1.full-html.html

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  DOI: 10.1101/2024.04.26.591029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11071485/
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Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription

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1. scibot 13 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.113816
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
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PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C

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1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.celrep.2023.113041
  
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cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
Jul 2024
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Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency

1
1. scibot 31 Jul 2024
  
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  DOI: 10.1007/s12185-024-03783-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284192/
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1

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1. scibot 27 Jul 2024
  
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  DOI: 10.1038/s41556-021-00813-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9022944/
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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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1. scibot 20 Jul 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.91766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
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The extracellular matrix integrates mitochondrial homeostasis

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.cell.2024.05.057
  
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sciencedirect.com/science/article/pii/S009286742400638X
www.embopress.org www.embopress.org

DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

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1. scibot 18 Jul 2024
  
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  plasmid_52962
  
  DOI: 10.1038/s44321-024-00088-0
  
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embopress.org/doi/10.1038/s44321-024-00088-0
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DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

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1. scibot 18 Jul 2024
  
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  plasmid_52962
  
  DOI: 10.1038/s44321-024-00088-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11251193/
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Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

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1. scibot 16 Jul 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1101/2024.07.09.602803
  
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biorxiv.org/content/10.1101/2024.07.09.602803v1
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Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis

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1. scibot 12 Jul 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2024.114477
  
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sciencedirect.com/science/article/pii/S2211124724008064
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Homologous recombination promotes mitotic death to suppress the innate immune response

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1. scibot 09 Jul 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1101/2024.05.04.592546
  
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biorxiv.org/content/10.1101/2024.05.04.592546v1
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Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets

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1. scibot 04 Jul 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1136/jitc-2024-009410
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11218003/
Jun 2024
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Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E

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1. scibot 30 Jun 2024
  
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  DOI: 10.3390/v16060898
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11209299/
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An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity

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1. scibot 30 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110131
  
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cell.com/iscience/abstract/S2589-0042(24)01356-7
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A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

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1. scibot 21 Jun 2024
  
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  DOI: 10.1101/2024.05.23.595417
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142209/
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Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential

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1. scibot 21 Jun 2024
  
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  DOI: 10.21203/rs.3.rs-4462139/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11160910/
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Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation

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1. scibot 20 Jun 2024
  
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  DOI: 10.1126/sciimmunol.adi1023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11182672/
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The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation

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1. scibot 15 Jun 2024
  
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  DOI: 10.1186/s13075-024-03350-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11165854/
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Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

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1. scibot 10 Jun 2024
  
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  DOI: 10.1038/s44320-024-00032-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148184/
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A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells

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1. scibot 07 Jun 2024
  
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  DOI: 10.1126/sciadv.adj1564
  
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  52962
  
  DOI: 10.1126/sciadv.adj1564
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
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A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

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1. scibot 06 Jun 2024
  
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  AddgeneCat# 52962
  
  DOI: 10.1016/j.xcrm.2024.101592
  
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  RRID:Addgene_52962 DOI:10.1016/j.xcrm.2024.101592
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sciencedirect.com/science/article/pii/S2666379124002842
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Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta

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  DOI: 10.1016/j.isci.2024.109921
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
May 2024
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The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes

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1. scibot 12 May 2024
  
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  Addgene_52962
  
  DOI: 10.1128/mbio.03429-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11078001/
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

1
1. scibot 09 May 2024
  
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  Addgene Cat# 52962
  
  DOI: 10.1016/j.celrep.2024.114211
  
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sciencedirect.com/science/article/pii/S2211124724005394
www.nature.com www.nature.com

De novo generation of multi-target compounds using deep generative chemistry

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  RRID:Addgene_52962
  
  DOI: 10.1038/s41467-024-47120-y
  
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nature.com/articles/s41467-024-47120-y
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Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition

1
1. scibot 05 May 2024
  
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  plasmid_52962
  
  DOI: 10.1038/s12276-024-01205-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11058268/
elifesciences.org elifesciences.org

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

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1. scibot 03 May 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.90683
  
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elifesciences.org/articles/90683
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Pooled multicolour tagging for visualizing subcellular protein dynamics

1
1. scibot 03 May 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s41556-024-01407-w
  
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nature.com/articles/s41556-024-01407-w
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

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1. scibot 02 May 2024
  
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  Addgene, #52962
  
  DOI: 10.1158/2643-3230.BCD-23-0014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10618724/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.04.006
  
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MYADM binds human parechovirus 1 and is essential for viral entry

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Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency

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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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  AddgeneCat# 52962
  
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Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma

1
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ncbi.nlm.nih.gov/pmc/articles/PMC11039739/
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ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

2
1. scibot 23 Apr 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996491/
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Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity

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Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens

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ncbi.nlm.nih.gov/pmc/articles/PMC10948361/
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HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14

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A fast-acting lipid checkpoint in G1 prevents mitotic defects

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ncbi.nlm.nih.gov/pmc/articles/PMC10948896/
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Activation of the insulin receptor by insulin-like growth factor 2

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Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

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Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma

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onlinelibrary.wiley.com/doi/10.1002/jcb.30542
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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

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  DOI: 10.1016/j.celrep.2024.114041
  
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sciencedirect.com/science/article/pii/S2211124724003693
Mar 2024
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CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects

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Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry

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A gut-derived hormone regulates cholesterol metabolism

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  DOI: 10.1016/j.cell.2024.02.024
  
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Genetic determinants of micronucleus formation in vivo

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ncbi.nlm.nih.gov/pmc/articles/PMC10917660/
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Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells

1
1. scibot 17 Mar 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
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A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells

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ncbi.nlm.nih.gov/pmc/articles/PMC10896345/
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Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC10528687/
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Functionally-instructed modifiers of response to ATR inhibition in experimental glioma

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ncbi.nlm.nih.gov/pmc/articles/PMC10935927/
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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In vivo CRISPR screening directly targeting testicular cells

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sciencedirect.com/science/article/pii/S2666979X24000375
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Extracting, filtering and simulating cellular barcodes using CellBarcode tools

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ncbi.nlm.nih.gov/pmc/articles/PMC10899113/
Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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  AddgeneCat#52962
  
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Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery

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  DOI: 10.1126/sciadv.adk3127
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10889360/
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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

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  DOI: 10.1126/sciadv.adj4767
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
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Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1

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ncbi.nlm.nih.gov/pmc/articles/PMC10761827/
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Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

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  DOI: 10.1101/2023.12.03.569825
  
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biorxiv.org/content/10.1101/2023.12.03.569825v1
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Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

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  Plasmid_52962
  
  DOI: 10.1101/2024.01.14.575614
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10827061/
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

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ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
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Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

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ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
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Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo

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  DOI: 10.1038/s41467-024-44931-x
  
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METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation

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  52962
  
  DOI: 10.1186/s13045-024-01526-9
  
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Two-step evolution of HIV-1 budding system leading to pandemic in the human population

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sciencedirect.com/science/article/pii/S2211124724000251
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Cell surface RNAs control neutrophil recruitment

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  AddgeneCat# 52962
  
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Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia

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  RRID:Addgene_52962
  
  DOI: 10.1038/s41598-024-52020-8
  
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Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

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sciencedirect.com/science/article/pii/S2211124723016406
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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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  Cat# 52962, Addgene
  
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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

1
1. scibot 20 Dec 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1158/0008-5472.CAN-22-2948
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
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Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.immuni.2023.11.008
  
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

1
1. scibot 15 Dec 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.87098
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
Nov 2023
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Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.xcrm.2023.101264
  
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2023.113352
  
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The promiscuous development of an unconventional Qa1b-restricted T cell population

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  RRID:Addgene_52962
  
  DOI: 10.3389/fimmu.2023.1250316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10644506/
Oct 2023
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Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

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  RRID:Addgene_52962
  
  DOI: 10.1101/2023.10.16.562592
  
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biorxiv.org/content/10.1101/2023.10.16.562592v1
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Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

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  RRID:Addgene_52962
  
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ADAR1 Biology Can Hinder Effective Antiviral RNA Interference

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  RRID:Addgene_52962
  
  DOI: 10.1128/jvi.00245-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10134826/
Sep 2023
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Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

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  plasmid_52962
  
  DOI: 10.1038/s41375-022-01755-2
  
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nature.com/articles/s41375-022-01755-2
Aug 2023
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Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

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  plasmid_52962
  
  DOI: 10.1101/2023.07.26.550648
  
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BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

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  RRID:Addgene_52962
  
  DOI: 10.1158/1541-7786.MCR-22-0594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9898120/
Jul 2023
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Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities

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  RRID:Addgene_52962
  
  DOI: 10.1038/s41594-023-01041-4
  
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nature.com/articles/s41594-023-01041-4
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Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation

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  RRID:Addgene_52962
  
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Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus

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  plasmid_52962
  
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APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer

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  plasmid_52962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350004/
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

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  Plasmid_52962
  
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cir-22-0815-html.html

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  DOI: 10.1158/2326-6066.CIR-22-0815
  
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52.53.155.43/0c7b493d1804c631a7718bd69d23acbb033c9efb/cir-22-0815-html.html
Jun 2023
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QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

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  DOI: 10.1016/j.cell.2023.05.047
  
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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

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Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

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  plasmid_52962
  
  DOI: 10.1101/2023.06.14.544493
  
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biorxiv.org/content/10.1101/2023.06.14.544493v1
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IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

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  DOI: 10.1016/j.immuni.2022.10.021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
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(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

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  RRID:Addgene_52962
  
  DOI: 10.1158/2159-8290.CD-22-0825
  
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aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
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RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition

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1. scibot 03 Jun 2023
  
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  RRID: Addgene_52962
  
  DOI: 10.1158/0008-5472.CAN-22-1549
  
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aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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  DOI: 10.1016/j.cell.2023.05.003
  
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sciencedirect.com/science/article/pii/S0092867423005226
May 2023
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Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

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  RRID:Addgene_52962
  
  DOI: 10.1101/2023.05.18.541265
  
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biorxiv.org/content/10.1101/2023.05.18.541265v1
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A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

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  DOI: 10.1073/pnas.2210623120
  
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pnas.org/doi/abs/10.1073/pnas.2210623120
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Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition

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1. scibot 05 May 2023
  
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  Addgene#52962
  
  DOI: 10.1016/j.celrep.2022.111117
  
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sciencedirect.com/science/article/pii/S2211124722009238
Apr 2023
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IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling

1
1. scibot 22 Apr 2023
  
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  plasmid_52962
  
  DOI: 10.1016/j.cellsig.2023.110684
  
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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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  DOI: 10.1158/2326-6066.CIR-22-0056
  
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aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
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Proteomic discovery of chemical probes that perturb protein complexes in human cells

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  DOI: 10.1016/j.molcel.2023.03.026
  
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Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens

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Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

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  DOI: 10.1101/2023.02.13.528260
  
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biorxiv.org/content/10.1101/2023.02.13.528260v1
Mar 2023
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Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer

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aacrjournals.org/cancerdiscovery/article/11/12/3214/674718/Rlf-Mycl-Gene-Fusion-Drives-Tumorigenesis-and
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FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

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  DOI: 10.1038/s41586-021-04144-4
  
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The protective role of conjunctival goblet cell mucin sialylation

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  DOI: 10.1038/s41467-023-37101-y
  
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In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

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Feb 2023
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An adverse tumor-protective effect of IDO1 inhibition

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91-html.html

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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

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  DOI: 10.1016/j.celrep.2023.112076
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
Jan 2023
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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

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  DOI: 10.1016/j.celrep.2023.112027
  
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Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

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Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

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  RRID:Addgene_52962
  
  DOI: 10.1111/jnc.15751
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15751
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METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

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  DOI: 10.1016/j.stem.2022.12.006
  
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Dec 2022
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

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embopress.org/doi/10.15252/emmm.202115631
Nov 2022
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

1
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  DOI: 10.1016/j.celrep.2022.111675
  
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sciencedirect.com/science/article/pii/S2211124722015492
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Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation

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  DOI: 10.1073/pnas.2122188119
  
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pnas.org/doi/abs/10.1073/pnas.2122188119
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

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  DOI: 10.1016/j.celrep.2022.111581
  
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Sep 2022
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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

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  DOI: 10.1038/s41467-022-32758-3
  
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nature.com/articles/s41467-022-32758-3
Aug 2022
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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

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  DOI: 10.1016/j.celrep.2022.111268
  
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Cancer genes disfavoring T cell immunity identified via integrated systems approach

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  DOI: 10.1016/j.celrep.2022.111153
  
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sciencedirect.com/science/article/pii/S2211124722009627
Jul 2022
www.jneurosci.org www.jneurosci.org

Modulating the excitability of olfactory output neurons affects whole-body metabolism

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  DOI: 10.1523/JNEUROSCI.0190-22.2022
  
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jneurosci.org/content/42/30/5966
Jun 2022
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Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells

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  DOI: 10.15252/embr.202154133
  
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embopress.org/doi/10.15252/embr.202154133
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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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  DOI: 10.1016/j.xcrm.2022.100655
  
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Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model

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  DOI: 10.1007/s10120-022-01307-8
  
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link.springer.com/article/10.1007/s10120-022-01307-8
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The SETDB1–TRIM28 complex suppresses antitumor immunity

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  RRID:Addgene_52962
  
  DOI: 10.1158/2326-6066.CIR-21-0754
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
May 2022
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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

1
1. scibot 18 May 2022
  
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  DOI: 10.7554/eLife.76541
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9094746/
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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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  DOI: 10.1158/2159-8290.CD-21-1006
  
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aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
Apr 2022
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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

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  DOI: 10.1016/j.celrep.2022.110637
  
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Mar 2022
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Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection

1
1. scibot 30 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110559
  
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Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

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  DOI: 10.7554/eLife.77444
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8942469/
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Partial p53 reactivation is sufficient to induce cancer regression

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  DOI: 10.1186/s13046-022-02269-6
  
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link.springer.com/article/10.1186/s13046-022-02269-6
Feb 2022
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ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells

1
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  DOI: 10.1016/j.canlet.2022.215601
  
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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells

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sciencedirect.com/science/article/pii/S2451945622000022
Jan 2022
www.nature.com www.nature.com

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

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  DOI: 10.1038/s42003-021-02953-x
  
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ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection

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  AddgeneCAT#52962
  
  DOI: 10.1016/j.isci.2021.103720
  
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sciencedirect.com/science/article/pii/S2589004221016904
Sep 2021
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Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition

1
1. scibot 04 Sep 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.3390/cancers13164227
  
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Aug 2021
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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

1
1. scibot 14 Aug 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.molcel.2019.03.025
  
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Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance

1
1. scibot 11 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2017.10.008
  
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Untitled document

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  DOI: 10.1038/s41598-018-37940-6
  
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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

2
1. scibot 05 Aug 2021
  
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  RRID:Addgene_529
  
  DOI: 10.1016/j.celrep.2021.109460
  
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2. scibot 01 Aug 2021
  
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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

1
1. scibot 01 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.celrep.2019.12.014
  
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sciencedirect.com/science/article/pii/S221112471931664X
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

1
1. scibot 29 Jul 2021
  
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  RRID: Addgene_52962
  
  DOI: 10.1016/j.cell.2019.10.034
  
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CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

1
1. scibot 28 Jul 2021
  
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  RRID:Addgene_ 52962
  
  DOI: 10.7554/eLife.43653
  
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Untitled document

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1. scibot 28 Jul 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2017.10.008
  
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cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 27 Jul 2021
  
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  RRID_Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

1
1. scibot 14 Jul 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2021.109378
  
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sciencedirect.com/science/article/pii/S2211124721007762
Jun 2021
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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

1
1. scibot 30 Jun 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.molcel.2021.06.020
  
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

1
1. scibot 25 Jun 2021
  
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  52962
  
  DOI: 10.1016/j.cell.2021.05.038
  
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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

1
1. scibot 25 Jun 2021
  
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  Cat#52962
  
  DOI: 10.1016/j.ccell.2021.06.003
  
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sciencedirect.com/science/article/pii/S1535610821002865
May 2021
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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

1
1. scibot 14 May 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cub.2021.04.075
  
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sciencedirect.com/science/article/pii/S0960982221006229
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Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

1
1. scibot 09 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.stem.2020.12.005
  
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sciencedirect.com/science/article/pii/S1934590920305890
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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

1
1. scibot 07 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2020.06.023
  
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sciencedirect.com/science/article/pii/S1097276520304251
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SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts

1
1. scibot 07 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2020.05.011
  
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sciencedirect.com/science/article/pii/S1097276520303129
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A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability

1
1. scibot 05 May 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.devcel.2020.07.022
  
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sciencedirect.com/science/article/pii/S1534580720305979
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Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

1
1. scibot 03 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2021.02.025
  
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sciencedirect.com/science/article/pii/S1097276521001350
Apr 2021
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

1
1. scibot 30 Apr 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.cmet.2020.12.003
  
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sciencedirect.com/science/article/pii/S1550413120306586
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Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors

1
1. scibot 28 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.chom.2020.05.012
  
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sciencedirect.com/science/article/pii/S1931312820302948
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Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

1
1. scibot 27 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.cels.2020.08.010
  
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sciencedirect.com/science/article/pii/S2405471220302945
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Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

1
1. scibot 24 Apr 2021
  
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  addgene_52962
  
  DOI: 10.1016/j.cell.2020.06.006
  
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sciencedirect.com/science/article/pii/S0092867420306930
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CRL4 AMBRA1 is a master regulator of D-type cyclins

1
1. scibot 22 Apr 2021
  
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  plasmid_52962
  
  DOI: 10.1038/s41586-021-03445-y
  
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nature.com/articles/s41586-021-03445-y
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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

1
1. scibot 20 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.ccell.2020.06.006
  
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

1
1. scibot 17 Apr 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2020.04.017
  
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sciencedirect.com/science/article/pii/S1535610820302166
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The dystonia gene THAP1 controls DNA double-strand break repair choice

1
1. scibot 15 Apr 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.molcel.2021.03.034
  
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sciencedirect.com/science/article/pii/S109727652100229X
Mar 2021
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

1
1. scibot 17 Mar 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.celrep.2021.108859
  
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sciencedirect.com/science/article/pii/S221112472100173X
Feb 2021
elifesciences.org elifesciences.org

Diverse viral proteases activate the NLRP1 inflammasome

1
1. scibot 28 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.60609
  
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elifesciences.org/articles/60609
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

1
1. scibot 26 Feb 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.cell.2020.09.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7489987/
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Vitamin B6 Addiction in Acute Myeloid Leukemia

1
1. scibot 24 Feb 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2019.12.002
  
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sciencedirect.com/science/article/pii/S1535610819305720
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TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cell.2020.12.005
  
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cell.com/cell/abstract/S0092-8674(20)31627-5
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N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1371/journal.ppat.1009244
  
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journals.plos.org/plospathogens/article
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 23 Feb 2021
  
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  RRID:_Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation

1
1. scibot 11 Feb 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2020.03.001
  
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sciencedirect.com/science/article/pii/S153561082030101X
Jan 2021
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Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

1
1. scibot 29 Jan 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.chom.2020.12.009
  
  Resource: RRID:Addgene_52962
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

sciencedirect.com/science/article/pii/S1931312820306715
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

1
1. scibot 29 Jan 2021
  
  in Public
  
  RRID:Addgene_52962
  
  DOI: 10.1016/j.cell.2020.12.006
  
  Resource: RRID:Addgene_52962
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRID:Addgene_52962

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7796900/
www.sciencedirect.com www.sciencedirect.com

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

1
1. scibot 20 Jan 2021
  
  in Public
  
  Addgene_52962
  
  DOI: 10.1016/j.xcrm.2020.100188
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_52962
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RRID:Addgene_52962

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URL

sciencedirect.com/science/article/pii/S2666379120302433
www.sciencedirect.com www.sciencedirect.com

The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

1
1. scibot 15 Jan 2021
  
  in Public
  
  Plasmid_52962
  
  DOI: 10.1016/j.chom.2020.04.024
  
  Resource: RRID:Addgene_52962
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_52962
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RRID:Addgene_52962

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scibot

URL

sciencedirect.com/science/article/pii/S1931312820302511
www.sciencedirect.com www.sciencedirect.com

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

1
1. scibot 07 Jan 2021
  
  in Public
  
  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108532
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

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sciencedirect.com/science/article/pii/S2211124720315217
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

1
1. scibot 09 Dec 2020
  
  in Public
  
  RRID:Addgene_52962
  
  DOI: 10.1038/s41419-020-03231-0
  
  Resource: RRID:Addgene_52962
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7705021/
www.sciencedirect.com www.sciencedirect.com

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

1
1. scibot 07 Dec 2020
  
  in Public
  
  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108444
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_52962
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720314339
Nov 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells

1
1. scibot 18 Nov 2020
  
  in Public
  
  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2020.09.014
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7737474/
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

2
1. scibot 14 Nov 2020
  
  in Public
  
  Addgene #52962
  
  DOI: 10.1016/j.celrep.2020.108371
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  Curator comments: lentiCas9-Blast
  
  What is this?
  
  RRID:Addgene_52962
2. scibot 14 Nov 2020
  
  in Public
  
  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108371
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_52962
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

pubmed.ncbi.nlm.nih.gov/33176151/
www.sciencedirect.com www.sciencedirect.com

G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

1
1. scibot 12 Nov 2020
  
  in Public
  
  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108341
  
  Resource: RRID:Addgene_52962
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
  What is this?
  
  RRID:Addgene_52962 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_52962

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720313309

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