1,029 Matching Annotations
  1. Feb 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
    1
    1. scibot 28 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1038/s41467-024-45902-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10894237/
  3. 52.53.155.43 52.53.155.43
    can-23-0555-html.html
    4
    1. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-0555

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    2. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-0555

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    3. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-0555

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    4. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-0555

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    52.53.155.43/e8db3efafb8a8253e8641e16f59e9a4a6a668dad/can-23-0555-html.html
  4. 52.53.155.43 52.53.155.43
    419-html.html
    3
    1. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-1082

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    2. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-1082

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    3. scibot 23 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.can-23-1082

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    52.53.155.43/9ee9b923ebb85a391d8ef40b8ed2af8f0d12ae03/419-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
    1
    1. scibot 22 Feb 2024
      Addgene Cat # 52961

      DOI: 10.1016/j.celrep.2024.113780

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    sciencedirect.com/science/article/pii/S2211124724001086
  6. www.biorxiv.org www.biorxiv.org
    New submission 27/09/2023, 09:17:54
    1
    1. scibot 21 Feb 2024
      52961

      DOI: 10.1101/2023.07.31.551317

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    biorxiv.org/content/10.1101/2023.07.31.551317v1
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6
    1
    1. scibot 21 Feb 2024
      52961

      DOI: 10.1101/2024.02.03.24302252

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    ncbi.nlm.nih.gov/pmc/articles/PMC10863003/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
    1
    1. scibot 21 Feb 2024
      52961

      DOI: 10.1038/s41392-024-01754-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10866945/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells
    1
    1. scibot 21 Feb 2024
      52961

      DOI: 10.1016/j.aninu.2024.01.001

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    ncbi.nlm.nih.gov/pmc/articles/PMC10867561/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
    1
    1. scibot 21 Feb 2024
      pLentiCRISPR v2

      DOI: 10.1038/s41467-024-45852-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873312/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
    1
    1. scibot 21 Feb 2024
      52961

      DOI: 10.1038/s41467-024-45633-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873344/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1
    1
    1. scibot 21 Feb 2024
      lentiCRISPRV2

      DOI: 10.1186/s12967-024-04970-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10874581/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A landscape of gene expression regulation for synovium in arthritis
    1
    1. scibot 21 Feb 2024
      Addgene_52961

      DOI: 10.1038/s41467-024-45652-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10869817/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
    1
    1. scibot 18 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1038/s43018-023-00539-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10867901/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
    1
    1. scibot 16 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.CAN-22-2220

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524031/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos
    1
    1. scibot 15 Feb 2024
      lenti-CRISPRv2

      DOI: 10.1038/s41420-024-01838-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10861449/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
    1
    1. scibot 15 Feb 2024
      52961

      DOI: 10.1063/5.0159330

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    ncbi.nlm.nih.gov/pmc/articles/PMC10864035/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma
    1
    1. scibot 15 Feb 2024
      plasmid_52961

      DOI: 10.3390/cells13030216

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    ncbi.nlm.nih.gov/pmc/articles/PMC10854781/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
    1
    1. scibot 15 Feb 2024
      Addgene_52961

      DOI: 10.1038/s41698-024-00508-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10861500/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
    1
    1. scibot 15 Feb 2024
      Addgene_52961

      DOI: 10.1101/2024.02.06.579191

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    pmc.ncbi.nlm.nih.gov/articles/PMC10871221/
  21. www.biorxiv.org www.biorxiv.org
    Circadian period is compensated for repressor protein turnover rates in single cells
    1
    1. scibot 15 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2024.02.06.579141

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    biorxiv.org/content/10.1101/2024.02.06.579141v1
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
    1
    1. scibot 15 Feb 2024
      Addgene_52961

      DOI: 10.1038/s41419-024-06422-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10861560/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
    1
    1. scibot 13 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44504-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762260/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
    1
    1. scibot 13 Feb 2024
      lentiCRISPR v2

      DOI: 10.1038/s41467-023-44412-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
    1
    1. scibot 13 Feb 2024
      lentiCRISPR v2

      DOI: 10.1038/s41467-023-44466-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761827/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive Plasma Membrane Turnover in T-REx293 cells via Ordered Membrane Domain Endocytosis under Mitochondrial Control
    1
    1. scibot 13 Feb 2024
      52961

      DOI: 10.1101/2024.01.17.576124

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    ncbi.nlm.nih.gov/pmc/articles/PMC10827192/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation
    1
    1. scibot 13 Feb 2024
      52961

      DOI: 10.1371/journal.ppat.1011934

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    ncbi.nlm.nih.gov/pmc/articles/PMC10846743/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
    1
    1. scibot 10 Feb 2024
      Addgene_52961

      DOI: 10.1016/j.isci.2024.109015

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    ncbi.nlm.nih.gov/pmc/articles/PMC10847737/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism
    1
    1. scibot 09 Feb 2024
      plasmid_52961

      DOI: 10.1016/j.isci.2024.109107

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879702/
  30. www.biorxiv.org www.biorxiv.org
    RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
    2
    1. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.10.570873

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    2. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.10.570873

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    biorxiv.org/content/10.1101/2023.12.10.570873v1
  31. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
    1. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    2. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    3. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-43650-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762000/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44624-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764363/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44502-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764958/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44580-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766649/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44572-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766965/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis
    1
    1. scibot 08 Feb 2024
      LentiCRISPRv2

      DOI: 10.1186/s12964-023-01456-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10768284/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.3390/cancers16010224

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    ncbi.nlm.nih.gov/pmc/articles/PMC10778361/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
    1
    1. scibot 08 Feb 2024
      Addgene_52961

      DOI: 10.1038/s41419-023-06395-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766628/
  40. www.sciencedirect.com www.sciencedirect.com
    p53 promotes antiviral innate immunity by driving hexosamine metabolism
    1
    1. scibot 07 Feb 2024
      Addgene_52961

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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
    1
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      52961

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
    1
    1. scibot 05 Feb 2024
      52961

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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
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      52961

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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity
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      52961

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  46. www.biorxiv.org www.biorxiv.org
    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression
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    1. scibot 05 Feb 2024
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splicing of latrophilin-3 controls synapse formation
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      52961

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1
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  51. www.nature.com www.nature.com
    Activation of recombinases at specific DNA loci by zinc-finger domain insertions
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      RRID:Addgene_52961

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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein
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      52,961

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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EPAC1 enhances brown fat growth and beige adipogenesis
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin
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      52961

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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis
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      52961

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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer
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      Addgene_52961

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  58. Jan 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
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    1. scibot 31 Jan 2024
      plasmid_52961

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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
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    1. scibot 30 Jan 2024
      Addgene, Watertown, MA, #52961

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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL
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      plasmid_52961

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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
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    1. scibot 30 Jan 2024
      plasmid_52961

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas
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      plasmid_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810843/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway
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    1. scibot 29 Jan 2024
      Addgene_52961

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  65. www.sciencedirect.com www.sciencedirect.com
    ATG14 plays a critical role in hepatic lipid droplet homeostasis
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      RRID: Addgene_52,961

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    sciencedirect.com/science/article/pii/S0026049523002974
  66. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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      Addgene_52961

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  67. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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      Addgene_52961

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  69. www.sciencedirect.com www.sciencedirect.com
    Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins
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      RRID:Addgene_52961

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  70. www.sciencedirect.com www.sciencedirect.com
    Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
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      RRID:Addgene_52961

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  71. www.biorxiv.org www.biorxiv.org
    RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
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  72. Dec 2023
  73. www.sciencedirect.com www.sciencedirect.com
    Human inherited CCR2 deficiency underlies progressive polycystic lung disease
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      plasmid_52961

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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein
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      DOI: 10.1128/jvi.00255-23

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  75. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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      RRID:Addgene_52961

      DOI: 10.1016/j.neuron.2023.11.020

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  76. www.sciencedirect.com www.sciencedirect.com
    Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth
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  77. www.sciencedirect.com www.sciencedirect.com
    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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      plasmid_52961

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  78. www.sciencedirect.com www.sciencedirect.com
    FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration
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  79. www.sciencedirect.com www.sciencedirect.com
    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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      plasmid_52961

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  80. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases
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      RRID:Addgene_52961

      DOI: 10.1172/JCI161142

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  82. www.biorxiv.org www.biorxiv.org
    Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint
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      plasmid_52961

      DOI: 10.1101/2021.04.21.440825

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    biorxiv.org/content/10.1101/2021.04.21.440825v1
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors
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      RRID:Addgene_52961

      DOI: 10.1158/2767-9764.CRC-23-0350

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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity
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      DOI: 10.1371/journal.pbio.3002381

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  85. www.sciencedirect.com www.sciencedirect.com
    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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  86. www.nature.com www.nature.com
    Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
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  87. link.springer.com link.springer.com
    Drug dependence in cancer is exploitable by optimally constructed treatment holidays
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  88. www.biorxiv.org www.biorxiv.org
    De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma
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  89. 52.53.155.43 52.53.155.43
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  90. www.sciencedirect.com www.sciencedirect.com
    Generation of a human embryonic stem cell reporter line, TMEM119-EGFP, for the visualisation of in vitro differentiated human microglia
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  91. Nov 2023
  92. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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  93. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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  94. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
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  95. www.science.org www.science.org
    Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer
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  96. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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  97. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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  98. Oct 2023
  99. www.sciencedirect.com www.sciencedirect.com
    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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  102. www.sciencedirect.com www.sciencedirect.com
    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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  103. www.biorxiv.org www.biorxiv.org
    Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination
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  104. www.biorxiv.org www.biorxiv.org
    Synaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function
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    Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer
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  106. www.cell.com www.cell.com
    MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
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    cell.com/cell-reports/abstract/S2211-1247(23)01034-3
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells
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  108. Sep 2023
  109. www.sciencedirect.com www.sciencedirect.com
    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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  111. www.embopress.org www.embopress.org
    IκB kinase-α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy
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  112. www.tandfonline.com www.tandfonline.com
    A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation
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  113. dx.doi.org dx.doi.org
    RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
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  115. dx.doi.org dx.doi.org
    Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation
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  117. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
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  119. Aug 2023
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
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  122. www.nature.com www.nature.com
    Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
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  123. www.sciencedirect.com www.sciencedirect.com
    Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
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  124. link.springer.com link.springer.com
    The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication
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    Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Porcine reproductive and respiratory syndrome virus upregulates SMPDL3B to promote viral replication by modulating lipid metabolism
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  127. 52.53.155.43 52.53.155.43
    Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses
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  128. 52.53.155.43 52.53.155.43
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle
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  131. www.sciencedirect.com www.sciencedirect.com
    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
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  132. Jul 2023
  133. www.embopress.org www.embopress.org
    Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
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    Interferon inhibits a model RNA virus via a limited set of inducible effector genes
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  135. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer
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  137. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
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    Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prenatal Δ9-tetrahydrocannabinol exposure in males leads to motivational disturbances related to striatal epigenetic dysregulation
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  141. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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  142. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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  143. 52.53.155.43 52.53.155.43
    qiad076-html.html
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-reactivity of anti-human programmed cell death ligand 1 (PD-L1) monoclonal antibody, clone 28-8 against feline PD-L1
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  145. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
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  146. Jun 2023
  147. www.sciencedirect.com www.sciencedirect.com
    Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth
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  148. 52.53.155.43 52.53.155.43
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  149. www.sciencedirect.com www.sciencedirect.com
    A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy
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  150. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
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  151. www.nature.com www.nature.com
    The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
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  152. www.sciencedirect.com www.sciencedirect.com
    Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
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    FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting fatty acid reprogramming suppresses CARM1-expressing ovarian cancer
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  155. www.biorxiv.org www.biorxiv.org
    Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism
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  156. www.biorxiv.org www.biorxiv.org
    IKKα kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy
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  157. www.embopress.org www.embopress.org
    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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  158. www.sciencedirect.com www.sciencedirect.com
    Acetate controls endothelial-to-mesenchymal transition
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  159. www.sciencedirect.com www.sciencedirect.com
    A mitochondrial iron-responsive pathway regulated by DELE1
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics
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  161. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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  162. aacrjournals.org aacrjournals.org
    EBV-upregulated B7-H3 inhibits NK cell-mediated antitumor function and contributes to nasopharyngeal carcinoma progression
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    aacrjournals.org/cancerimmunolres/article/11/6/830/726521/EBV-Upregulated-B7-H3-Inhibits-NK-cell-Mediated
  163. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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  164. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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  165. www.sciencedirect.com www.sciencedirect.com
    Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2
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  166. www.embopress.org www.embopress.org
    STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
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  168. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dual VEGFA/BRAF targeting boosts PD-1 blockade in melanoma through GM-CSF-mediated infiltration of M1 macrophages
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  169. May 2023
  170. www.sciencedirect.com www.sciencedirect.com
    EWSR1 maintains centromere identity
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  171. www.sciencedirect.com www.sciencedirect.com
    CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis
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  172. www.biorxiv.org www.biorxiv.org
    Copyback viral genomes trigger stress granule formation independent of the antiviral response to interfere with viral translation in acute and persistent infections
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  173. www.sciencedirect.com www.sciencedirect.com
    Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
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      DOI: 10.1016/j.celrep.2023.112538

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    sciencedirect.com/science/article/pii/S2211124723005491
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization
    1
    1. scibot 21 May 2023
      plasmid_52961

      DOI: 10.7554/eLife.85167

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    ncbi.nlm.nih.gov/pmc/articles/PMC10191626/
  175. www.biorxiv.org www.biorxiv.org
    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    1. scibot 18 May 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.05.11.540429

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    biorxiv.org/content/10.1101/2023.05.11.540429v1
  176. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin-independent proteasomal degradation driven by C-degron pathways
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    1. scibot 18 May 2023
      Addgene_52961

      DOI: 10.1016/j.molcel.2023.04.023

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    sciencedirect.com/science/article/pii/S1097276523003179
  177. www.sciencedirect.com www.sciencedirect.com
    Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis
    1
    1. scibot 17 May 2023
      Plasmid_52961

      DOI: 10.1016/j.isci.2023.106791

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    sciencedirect.com/science/article/pii/S2589004223008684
  178. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
    2
    1. scibot 10 May 2023
      RRID: Addgene_52961

      DOI: 10.1016/j.celrep.2023.112484

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      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112484

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    sciencedirect.com/science/article/pii/S2211124723004953
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized metrics for orthogonal combinatorial CRISPR screens
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    1. scibot 09 May 2023
      RRID:Addgene_52961

      DOI: 10.1038/s41598-023-34597-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10164157/
  180. www.mdpi.com www.mdpi.com
    Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses
    1
    1. scibot 06 May 2023
      52961

      DOI: 10.3390/cells10102600

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    mdpi.com/2073-4409/10/10/2600/htm
  181. www.nature.com www.nature.com
    Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
    2
    1. scibot 06 May 2023
      plasmid_52961

      DOI: 10.1038/s41467-023-38316-9

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      RRID:Addgene_5296153

      DOI: 10.1038/s41467-023-38316-9

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    nature.com/articles/s41467-023-38316-9
  182. www.sciencedirect.com www.sciencedirect.com
    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
    1
    1. scibot 05 May 2023
      Plasmid_52961

      DOI: 10.1016/j.celrep.2022.111092

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    sciencedirect.com/science/article/pii/S2211124722008944
  183. journals.asm.org journals.asm.org
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
    1
    1. scibot 05 May 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.01055-22

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    journals.asm.org/doi/10.1128/mbio.01055-22
  184. www.mdpi.com www.mdpi.com
    Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells
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    1. scibot 04 May 2023
      plasmid_52961

      DOI: 10.3390/ijms24097792

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    mdpi.com/1422-0067/24/9/7792
  185. journals.asm.org journals.asm.org
    Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
    1
    1. scibot 04 May 2023
      RRID:Addgene_52961

      DOI: 10.1128/jvi.00093-23

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    journals.asm.org/doi/10.1128/jvi.00093-23
  186. Apr 2023
  187. www.nature.com www.nature.com
    Development of anti-feline PD-1 antibody and its functional analysis
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    1. scibot 25 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1038/s41598-023-31543-6

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    nature.com/articles/s41598-023-31543-6
  188. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
    1
    1. scibot 21 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1158/2326-6066.CIR-22-0056

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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  189. www.sciencedirect.com www.sciencedirect.com
    A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer
    1
    1. scibot 21 Apr 2023
      Addgene_52961

      DOI: 10.1016/j.isci.2023.106525

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    sciencedirect.com/science/article/pii/S2589004223006028
  190. www.sciencedirect.com www.sciencedirect.com
    VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms
    1
    1. scibot 20 Apr 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2023.112209

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    sciencedirect.com/science/article/pii/S2211124723002206
  191. www.biorxiv.org www.biorxiv.org
    Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons
    1
    1. scibot 20 Apr 2023
      Addgene_52961

      DOI: 10.1101/2023.04.05.535694

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    biorxiv.org/content/10.1101/2023.04.05.535694v1
  192. www.sciencedirect.com www.sciencedirect.com
    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
    1
    1. scibot 19 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2023.03.002

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    sciencedirect.com/science/article/pii/S1535610823000508
  193. www.nature.com www.nature.com
    Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis
    1
    1. scibot 18 Apr 2023
      Plasmid_52961

      DOI: 10.1038/s41467-023-37924-9

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    nature.com/articles/s41467-023-37924-9
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-suppressor scanning for systematic discovery of drug resistance mutations
    1
    1. scibot 12 Apr 2023
      Addgene_52961

      DOI: 10.1002/cpz1.614

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    ncbi.nlm.nih.gov/pmc/articles/PMC10073897/
  195. www.sciencedirect.com www.sciencedirect.com
    The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
    1
    1. scibot 06 Apr 2023
      Plasmid_52961

      DOI: 10.1016/j.immuni.2023.03.003

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    sciencedirect.com/science/article/pii/S1074761323001231
  196. Mar 2023
  197. www.biorxiv.org www.biorxiv.org
    Alternative splicing of its 5’ untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies
    1
    1. scibot 31 Mar 2023
      plasmid_52961

      DOI: 10.1101/2023.02.19.529123

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    biorxiv.org/content/10.1101/2023.02.19.529123v2
  198. www.biorxiv.org www.biorxiv.org
    Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
    1
    1. scibot 31 Mar 2023
      Addgene_52961

      DOI: 10.1101/2023.03.24.534139

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    biorxiv.org/content/10.1101/2023.03.24.534139v1