1,515 Matching Annotations
  1. Feb 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles
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    pmc.ncbi.nlm.nih.gov/articles/PMC11820142/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11816549/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11817321/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo CRISPR–Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821541/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bat genomes illuminate adaptations to viral tolerance and disease resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821529/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811203/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circadian period is compensated for repressor protein turnover rates in single cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11348271/
  10. www.cell.com www.cell.com
    Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma
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    cell.com/cancer-cell/abstract/S1535-6108(25)00027-3
  11. www.sciencedirect.com www.sciencedirect.com
    RIOK3 mediates the degradation of 40S ribosomes
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    sciencedirect.com/science/article/pii/S1097276525000486
  12. aacrjournals.org aacrjournals.org
    MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
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    aacrjournals.org/clincancerres/article/30/22/5154/749570/MEK-Inhibitors-Lead-to-PDGFR-Pathway-Upregulation
  13. aacrjournals.org aacrjournals.org
    A novel human SDHA‑knockout cell line model for the functional analysis of clinically‑relevant SDHA variants
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    aacrjournals.org/clincancerres/article/30/23/5399/750191/A-Novel-Human-SDHA-Knockout-Cell-Line-Model-for
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11346591/
  16. www.sciencedirect.com www.sciencedirect.com
    GUK1 activation is a metabolic liability in lung cancer
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    sciencedirect.com/science/article/pii/S0092867425000935
  17. 52.53.155.43 52.53.155.43
    Single cell variation and rapid emergence of phenotypic heterogeneity in cell lines- a cautionary tale for devotees of CRISPR-Cas9.
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    52.53.155.43/6c385708921a0bf3be8e1bc925dfecc0377aeb77/2024.09.27.615490.full-html.html
  18. Jan 2025
  19. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/c74348c45bccaf197fb20d31d8b35ab413c8424c/PDF-html.html
  20. link.springer.com link.springer.com
    Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells
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    link.springer.com/article/10.1007/s11033-025-10272-1
  21. elifesciences.org elifesciences.org
    PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
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    elifesciences.org/articles/102852
  22. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741350/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11160912/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11756136/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats
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    pmc.ncbi.nlm.nih.gov/articles/PMC11734463/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735100/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional regulation of adipocyte lipolysis by IRF2BP2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11698119/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WWC proteins–mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11753430/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell cycle progression of under-replicated cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707533/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11740687/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanisms of KRAS inhibitor resistance in KRAS-mutant colorectal cancer harboring Her2 amplification and aberrant KRAS localization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704227/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A
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    pmc.ncbi.nlm.nih.gov/articles/PMC11747100/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Herpesviruses mimic zygotic genome activation to promote viral replication
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735616/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse
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    pmc.ncbi.nlm.nih.gov/articles/PMC11759703/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11758775/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VCP regulates early tau seed amplification via specific cofactors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707990/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-base m6A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4+ T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11722377/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695977/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707192/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617306/
  42. www.sciencedirect.com www.sciencedirect.com
    MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1
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    sciencedirect.com/science/article/pii/S2666379124006931
  43. www.sciencedirect.com www.sciencedirect.com
    C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes
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    sciencedirect.com/science/article/pii/S1097276524007330
  44. www.sciencedirect.com www.sciencedirect.com
    TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress
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    sciencedirect.com/science/article/pii/S2211124724015183
  45. 52.53.155.43 52.53.155.43
    Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function
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    52.53.155.43/bb3fc3d48d1d1a3ea4bd88205a0b31e5070fc2a9/PDF-html.html
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
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    pmc.ncbi.nlm.nih.gov/articles/PMC11701132/
  47. www.sciencedirect.com www.sciencedirect.com
    Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9
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    sciencedirect.com/science/article/pii/S1534580724007342
  48. www.sciencedirect.com www.sciencedirect.com
    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  49. www.cell.com www.cell.com
    The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
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    cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
  50. www.tandfonline.com www.tandfonline.com
    Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
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    tandfonline.com/doi/full/10.1080/15548627.2024.2443300
  51. Dec 2024
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response
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    pmc.ncbi.nlm.nih.gov/articles/PMC11675146/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Intrinsic Immunogenicity Suppressor SETDB1 Worsens the Prognosis of Patients with Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11675013/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Upregulated YTHDC1 mediates trophoblastic dysfunction inducing preterm birth in ART conceptions through enhanced RPL37 translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671673/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11661309/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11178506/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654995/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652373/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671023/
  61. www.pnas.org www.pnas.org
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1
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    pnas.org/doi/abs/10.1073/pnas.2402849121
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PP2A B55α Inhibits Epithelial-Mesenchymal Transition Via Regulation of Slug Expression in Non-Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11670312/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LMAN1 serves as a cargo receptor for thrombopoietin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665562/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652640/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17
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    pmc.ncbi.nlm.nih.gov/articles/PMC11648071/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654918/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667163/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11660903/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11663225/
  70. www.sciencedirect.com www.sciencedirect.com
    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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    sciencedirect.com/science/article/pii/S1097276524009511
  71. www.sciencedirect.com www.sciencedirect.com
    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    sciencedirect.com/science/article/pii/S2405471224003375
  72. www.sciencedirect.com www.sciencedirect.com
    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    sciencedirect.com/science/article/pii/S1535610824004434
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retargeting target-directed microRNA-decay sites to highly expressed viral or cellular miRNAs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11662681/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532483/
  75. www.sciencedirect.com www.sciencedirect.com
    Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells
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    sciencedirect.com/science/article/pii/S1534580724007214
  76. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11605321/
  78. elifesciences.org elifesciences.org
    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    elifesciences.org/reviewed-preprints/102852
  79. www.sciencedirect.com www.sciencedirect.com
    Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice
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    sciencedirect.com/science/article/pii/S2211124724014207
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11612623/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Control of cell proliferation by memories of mitosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11621110/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11616604/
  83. www.sciencedirect.com www.sciencedirect.com
    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
  84. www.science.org www.science.org
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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    science.org/doi/10.1126/science.adq8587
  85. www.nature.com www.nature.com
    Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
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    nature.com/articles/s42255-024-01166-w
  86. Nov 2024
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11583848/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting
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    pmc.ncbi.nlm.nih.gov/articles/PMC11579293/
  89. www.sciencedirect.com www.sciencedirect.com
    Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
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  180. Aug 2024
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression
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    Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair
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    A genetic basis for sex differences in Xp11 translocation renal cell carcinoma
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