1,029 Matching Annotations
  1. Mar 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy
    1
    1. scibot 29 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1158/2767-9764.CRC-22-0208

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    ncbi.nlm.nih.gov/pmc/articles/PMC7613873/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade
    1
    1. scibot 26 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1038/s41467-023-36878-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10033639/
  4. www.sciencedirect.com www.sciencedirect.com
    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
    1
    1. scibot 16 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2023.02.005

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    sciencedirect.com/science/article/pii/S1535610823000338
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer
    1
    1. scibot 16 Mar 2023
      Addgene_52961

      DOI: 10.18632/genesandcancer.231

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    ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
  6. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
    1
    1. scibot 09 Mar 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2023.112219

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    sciencedirect.com/science/article/pii/S2211124723002309
  7. www.biorxiv.org www.biorxiv.org
    KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein
    1
    1. scibot 09 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.03.01.530732

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    biorxiv.org/content/10.1101/2023.03.01.530732v1
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus
    1
    1. scibot 05 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.03114-22

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    ncbi.nlm.nih.gov/pmc/articles/PMC9973313/
  9. www.biorxiv.org www.biorxiv.org
    LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes
    1
    1. scibot 03 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.01.31.526513

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    biorxiv.org/content/10.1101/2023.01.31.526513v1
  10. www.biorxiv.org www.biorxiv.org
    SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
    1
    1. scibot 03 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.01.14.524054

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    biorxiv.org/content/10.1101/2023.01.14.524054v1
  11. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
    1
    1. scibot 02 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112185

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    sciencedirect.com/science/article/pii/S2211124723001961
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery
    1
    1. scibot 02 Mar 2023
      Addgene_52961

      DOI: 10.7554/eLife.80640

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    ncbi.nlm.nih.gov/pmc/articles/PMC9946446/
  13. Feb 2023
  14. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
    1
    1. scibot 23 Feb 2023
      RRID: Addgene_52961

      DOI: 10.1016/j.xcrm.2023.100941

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    sciencedirect.com/science/article/pii/S2666379123000332
  15. www.sciencedirect.com www.sciencedirect.com
    Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes
    1
    1. scibot 23 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.bpj.2023.02.006

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    sciencedirect.com/science/article/pii/S000634952300098X
  16. www.nature.com www.nature.com
    ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
    1
    1. scibot 11 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1038/s12276-023-00945-x

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    nature.com/articles/s12276-023-00945-x
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
    1
    1. scibot 11 Feb 2023
      Addgene_52961

      DOI: 10.1371/journal.ppat.1011101

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    ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
    1
    1. scibot 08 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112076

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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
    1
    1. scibot 04 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1158/2326-6066.CIR-22-0088

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357105/
  20. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
    1
    1. scibot 02 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1186/s12964-022-01033-9

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-022-01033-9
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
    1
    1. scibot 01 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1007/s00395-023-00978-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC9879848/
  22. Jan 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
    1
    1. scibot 25 Jan 2023
      RRID:Addgene_52961

      DOI: 10.3389/fcell.2022.1080626

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    ncbi.nlm.nih.gov/pmc/articles/PMC9852825/
  24. www.nature.com www.nature.com
    Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma
    1
    1. scibot 21 Jan 2023
      plasmid_52961

      DOI: 10.1038/s41467-023-35796-7

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    nature.com/articles/s41467-023-35796-7
  25. www.sciencedirect.com www.sciencedirect.com
    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
    1
    1. scibot 21 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112012

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    sciencedirect.com/science/article/pii/S2211124723000232
  26. journals.asm.org journals.asm.org
    LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus
    1
    1. scibot 19 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.03114-22

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    journals.asm.org/doi/10.1128/mbio.03114-22
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
    1
    1. scibot 15 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1158/2159-8290.CD-22-0427

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827116/
  28. 52.53.155.43 52.53.155.43
    SSRN-id4265019-html.html
    3
    1. scibot 14 Jan 2023
      RRID:Addgene_52961

      DOI: 10.2139/ssrn.4265019

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      RRID:Addgene_52961

      DOI: 10.2139/ssrn.4265019

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    3. scibot 14 Jan 2023
      RRID:Addgene_529

      DOI: 10.2139/ssrn.4265019

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    52.53.155.43/7fa70c9c4ef484c26f104e85bcdc5ead50c41c8f/SSRN-id4265019-html.html
  29. link.springer.com link.springer.com
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
    1
    1. scibot 14 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1007/s00125-022-05856-6

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    link.springer.com/article/10.1007/s00125-022-05856-6
  30. 52.53.155.43 52.53.155.43
    SSRN-id4267401-html.html
    1
    1. scibot 14 Jan 2023
      RRID:Addgene_5296

      DOI: 10.1016/s0140-6736(11)60281-x

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    52.53.155.43/bc0966ab9ec7f3ddd2e8c12d6f5511c81b996a3a/SSRN-id4267401-html.html
  31. www.mdpi.com www.mdpi.com
    Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability
    1
    1. scibot 12 Jan 2023
      RRID:Addgene_52961

      DOI: 10.3390/cancers15020369

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    mdpi.com/2072-6694/15/2/369
  32. www.sciencedirect.com www.sciencedirect.com
    DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling
    1
    1. scibot 12 Jan 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2022.111986

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    sciencedirect.com/science/article/pii/S2211124722018903
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
    1
    1. scibot 11 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1371/journal.ppat.1010800

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    ncbi.nlm.nih.gov/pmc/articles/PMC9829182/
  34. www.sciencedirect.com www.sciencedirect.com
    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
    1
    1. scibot 10 Jan 2023
      Addgene_52961

      DOI: 10.1016/j.immuni.2022.11.014

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    sciencedirect.com/science/article/pii/S1074761322006045
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
    1
    1. scibot 07 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1158/2159-8290.CD-21-1671

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    ncbi.nlm.nih.gov/pmc/articles/PMC9437570/
  36. www.sciencedirect.com www.sciencedirect.com
    Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis
    1
    1. scibot 07 Jan 2023
      Plasmid_52961

      DOI: 10.1016/j.celrep.2022.111948

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    sciencedirect.com/science/article/pii/S2211124722018496
  37. www.sciencedirect.com www.sciencedirect.com
    Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis
    1
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      RRID:Addgene_52961

      DOI: 10.1016/j.joca.2022.12.010

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    sciencedirect.com/science/article/pii/S1063458423000018
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting
    1
    1. scibot 06 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1080/19768354.2022.2151509

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    ncbi.nlm.nih.gov/pmc/articles/PMC9809370/
  39. www.sciencedirect.com www.sciencedirect.com
    Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response
    1
    1. scibot 05 Jan 2023
      Plasmid_52961

      DOI: 10.1016/j.molcel.2022.12.007

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    sciencedirect.com/science/article/pii/S1097276522011649
  40. www.sciencedirect.com www.sciencedirect.com
    Functional partitioning of transcriptional regulators by patterned charge blocks
    1
    1. scibot 05 Jan 2023
      Addgene_52961

      DOI: 10.1016/j.cell.2022.12.013

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    sciencedirect.com/science/article/pii/S0092867422015264
  41. www.sciencedirect.com www.sciencedirect.com
    Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy
    1
    1. scibot 04 Jan 2023
      Plasmid_52961

      DOI: 10.1016/j.molcel.2022.12.002

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    sciencedirect.com/science/article/pii/S1097276522011376
  42. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
    1
    1. scibot 02 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2022.12.003

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    cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
  43. Dec 2022
  44. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    4
    1. scibot 31 Dec 2022
      RRID:Addgene_52961

      DOI: 10.15252/embj.2022111961

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    2. scibot 31 Dec 2022
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      DOI: 10.15252/embj.2022111961

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    3. scibot 31 Dec 2022
      Addgene_5296

      DOI: 10.15252/embj.2022111961

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    4. scibot 31 Dec 2022
      Addgene_5296

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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the metabolic role of STAT3 in canine osteosarcoma
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy
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  47. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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  48. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
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  50. www.sciencedirect.com www.sciencedirect.com
    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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  51. www.nature.com www.nature.com
    SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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  53. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
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  55. www.tandfonline.com www.tandfonline.com
    Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting
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    Specific and efficient gene knockout and overexpression in mouse interscapular brown adipocytes in vivo
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  57. www.sciencedirect.com www.sciencedirect.com
    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
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  58. Nov 2022
  59. www.sciencedirect.com www.sciencedirect.com
    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
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  60. www.liebertpub.com www.liebertpub.com
    Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation
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  61. www.sciencedirect.com www.sciencedirect.com
    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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  62. www.nature.com www.nature.com
    Arc controls alcohol cue relapse by a central amygdala mechanism
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  63. www.researchsquare.com www.researchsquare.com
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  64. www.sciencedirect.com www.sciencedirect.com
    Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation
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  65. www.sciencedirect.com www.sciencedirect.com
    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosome Docking to WIPI1 Rings and ER-connected Phagophores Occurs During DNAJB12 and GABARAP-Dependent Selective Autophagy of Misfolded P23H-Rhodopsin
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  67. elifesciences.org elifesciences.org
    Genome-wide base editor screen identifies regulators of protein abundance in yeast
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  68. www.sciencedirect.com www.sciencedirect.com
    Multiphase coalescence mediates Hippo pathway activation
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  69. 52.53.155.43 52.53.155.43
    The lysosome membrane protein, Sidt2: A novel insulin granule membrane protein regulates β cell dedifferentiation by a new pathway involving insulin secretion
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  70. 52.53.155.43 52.53.155.43
    Arc controls alcohol cue relapse by a central amygdala mechanism
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  71. www.nature.com www.nature.com
    HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex
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  72. Oct 2022
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons
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  75. Sep 2022
  76. www.sciencedirect.com www.sciencedirect.com
    De novo sphingolipid biosynthesis necessitates detoxification in cancer cells
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Zinc-finger antiviral protein-mediated inhibition of porcine epidemic diarrhea virus growth is antagonized by the coronaviral nucleocapsid protein
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    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
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    CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation
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  80. www.nature.com www.nature.com
    Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
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  82. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function
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  83. www.sciencedirect.com www.sciencedirect.com
    S1-END-seq reveals DNA secondary structures in human cells
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
    1
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  85. Aug 2022
  86. www.sciencedirect.com www.sciencedirect.com
    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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  87. www.sciencedirect.com www.sciencedirect.com
    Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance
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      AddgeneCat#52961

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  88. 52.53.155.43 52.53.155.43
    cd-21-1671-html.html
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  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation
    1
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      DOI: 10.1002/advs.202202834

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  90. www.sciencedirect.com www.sciencedirect.com
    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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    The redox cycling of STAT2 maintains innate immune homeostasis
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  92. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
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    Discovery of compounds that reactivate p53 mutants in vitro and in vivo
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
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  95. www.sciencedirect.com www.sciencedirect.com
    Prominin1 and Notch Regulate Ciliary Length and Dynamics in Multiciliated Cells of the Airway Epithelium.
    2
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  96. www.sciencedirect.com www.sciencedirect.com
    Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
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  97. Jul 2022
  98. 52.53.155.43 52.53.155.43
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  99. www.sciencedirect.com www.sciencedirect.com
    FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia
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    Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer
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  102. Jun 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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  106. www.sciencedirect.com www.sciencedirect.com
    Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma
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  107. aacrjournals.org aacrjournals.org
    Vitamin D Receptor activation attenuates Hippo pathway effectors and cell survival in metastatic neuroblastoma
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  108. www.nature.com www.nature.com
    BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
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  109. ar.iiarjournals.org ar.iiarjournals.org
    LXRβ Activation Inhibits the Proliferation of Small-cell Lung Cancer Cells by Depleting Cellular Cholesterol
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  110. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast
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  113. elifesciences.org elifesciences.org
    Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
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    RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  118. www.nature.com www.nature.com
    HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function
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  119. www.sciencedirect.com www.sciencedirect.com
    Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  122. May 2022
  123. link.springer.com link.springer.com
    Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation
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  124. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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  128. www.sciencedirect.com www.sciencedirect.com
    Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells
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  129. aacrjournals.org aacrjournals.org
    Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
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  130. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development
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  133. www.science.org www.science.org
    The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development
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  134. www.sciencedirect.com www.sciencedirect.com
    Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit
    2
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      RRID: Addgene 52961

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    sciencedirect.com/science/article/pii/S0021925822004446
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
    1
    1. scibot 05 May 2022
      RRID:Addgene_52961

      DOI: 10.1096/fj.202200154R

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    ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
  136. Apr 2022
  137. www.sciencedirect.com www.sciencedirect.com
    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
    1
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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1534580722002507
  138. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
    1
    1. scibot 23 Apr 2022
      RRID:Addgene_52961

      DOI: 10.1038/s41392-022-00946-8

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    nature.com/articles/s41392-022-00946-8
  139. www.sciencedirect.com www.sciencedirect.com
    Establishing transgenic murine esophageal organoids
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      AddgeneCat#52961

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    sciencedirect.com/science/article/pii/S2666166722001976
  140. aacrjournals.org aacrjournals.org
    CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses
    1
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      plasmid_52961

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    aacrjournals.org/cancerimmunolres/article/10/4/525/689540/CDK2-Inhibition-Enhances-Antitumor-Immunity-by
  141. www.sciencedirect.com www.sciencedirect.com
    In vitro and in vivo assay of the ER lipid scramblase TMEM41B
    1
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      Addgene Cat# 52961

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  142. www.sciencedirect.com www.sciencedirect.com
    Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity
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      AddgeneCat# 52961

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    sciencedirect.com/science/article/pii/S1550413122001267
  143. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1534580722002295
  144. www.sciencedirect.com www.sciencedirect.com
    Rapid establishment of human colonic organoid knockout lines
    1
    1. scibot 14 Apr 2022
      plasmid_52961

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    sciencedirect.com/science/article/pii/S2666166722001885
  145. www.nature.com www.nature.com
    CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
    1
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    nature.com/articles/s41467-022-29469-0
  146. www.nature.com www.nature.com
    Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy
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  147. www.sciencedirect.com www.sciencedirect.com
    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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  148. www.sciencedirect.com www.sciencedirect.com
    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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      RRID:Addgene_52961

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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a CHIP isogenic human iPSC-derived cortical neuron model for functional proteomics
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8980993/
  150. Mar 2022
  151. academic.oup.com academic.oup.com
    Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor
    1
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac178/6553119
  152. www.sciencedirect.com www.sciencedirect.com
    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    sciencedirect.com/science/article/pii/S2451945622000940
  153. www.nature.com www.nature.com
    PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
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      RRID:Addgene_52961

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  154. www.sciencedirect.com www.sciencedirect.com
    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    sciencedirect.com/science/article/pii/S2211124722002066
  155. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
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  156. www.nature.com www.nature.com
    Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
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      DOI: 10.1038/s41596-021-00669-0

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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
    1
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      DOI: 10.7554/eLife.65421

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  159. www.sciencedirect.com www.sciencedirect.com
    Recruitment of DNA to tumor-derived microvesicles
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    sciencedirect.com/science/article/pii/S221112472200170X
  160. Feb 2022
  161. www.sciencedirect.com www.sciencedirect.com
    Systematic illumination of druggable genes in cancer genomes
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  162. www.sciencedirect.com www.sciencedirect.com
    HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
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  163. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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  164. www.sciencedirect.com www.sciencedirect.com
    Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells
    2
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Correction of a Factor VIII genomic inversion with designer-recombinases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8776779/
  166. www.sciencedirect.com www.sciencedirect.com
    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
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  167. www.sciencedirect.com www.sciencedirect.com
    ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression
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  168. Jan 2022
  169. elifesciences.org elifesciences.org
    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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      DOI: 10.7554/eLife.73137

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  170. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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  171. www.sciencedirect.com www.sciencedirect.com
    Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors
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  172. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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  173. www.sciencedirect.com www.sciencedirect.com
    Modeling cell protrusion predicts how Myosin II and actin turnover affect adhesion-based signaling
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  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    https://biorxiv.org/cgi/content/10.1101/2021.12.10.472112
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  175. Dec 2021
  176. www.sciencedirect.com www.sciencedirect.com
    Assessing kinetics and recruitment of DNA repair factors using high content screens
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
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  178. www.sciencedirect.com www.sciencedirect.com
    Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts
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      DOI: 10.3389/fcell.2021.778887

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    ncbi.nlm.nih.gov/pmc/articles/PMC8639228/
  180. Nov 2021
  181. www.sciencedirect.com www.sciencedirect.com
    HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
    1
    1. scibot 30 Nov 2021
      Cat# 52961

      DOI: 10.1016/j.molcel.2021.10.028

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    sciencedirect.com/science/article/pii/S1097276521009485
  182. onlinelibrary.wiley.com onlinelibrary.wiley.com
    β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia
    1
    1. scibot 30 Nov 2021
      addgene_52961

      DOI: 10.1111/jcmm.17060

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    onlinelibrary.wiley.com/doi/10.1111/jcmm.17060
  183. www.sciencedirect.com www.sciencedirect.com
    PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ
    1
    1. scibot 23 Nov 2021
      Addgene, Cat# 52961

      DOI: 10.1016/j.chembiol.2021.11.001

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    sciencedirect.com/science/article/pii/S2451945621004785
  184. www.nature.com www.nature.com
    Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
    1
    1. scibot 21 Nov 2021
      RRID:Addgene_52961

      DOI: 10.1038/s41467-021-26823-6

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    nature.com/articles/s41467-021-26823-6
  185. www.sciencedirect.com www.sciencedirect.com
    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
    1
    1. scibot 10 Nov 2021
      plasmid_52961

      DOI: 10.1016/j.celrep.2021.109979

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    sciencedirect.com/science/article/pii/S2211124721014583
  186. Oct 2021
  187. www.sciencedirect.com www.sciencedirect.com
    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
    1
    1. scibot 29 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.isci.2021.103224

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    sciencedirect.com/science/article/pii/S2589004221011925
  188. www.sciencedirect.com www.sciencedirect.com
    GCN2 adapts protein synthesis to scavenging-dependent growth
    1
    1. scibot 27 Oct 2021
      Plasmid_52961

      DOI: 10.1016/j.cels.2021.09.014

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    sciencedirect.com/science/article/pii/S2405471221003823
  189. www.sciencedirect.com www.sciencedirect.com
    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
    1
    1. scibot 23 Oct 2021
      52961

      DOI: 10.1016/j.molcel.2021.10.005

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    sciencedirect.com/science/article/pii/S1097276521008340
  190. www.sciencedirect.com www.sciencedirect.com
    NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression
    1
    1. scibot 21 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2021.109856

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    sciencedirect.com/science/article/pii/S2211124721013231
  191. www.sciencedirect.com www.sciencedirect.com
    Aberrant RNA methylation triggers recruitment of an alkylation repair complex
    1
    1. scibot 21 Oct 2021
      Addgene_52961

      DOI: 10.1016/j.molcel.2021.09.024

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    sciencedirect.com/science/article/pii/S1097276521007772
  192. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites
    1
    1. scibot 18 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1111/febs.16202

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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.16202
  193. academic.oup.com academic.oup.com
    A role for AKT1 in nonsense-mediated mRNA decay
    1
    1. scibot 15 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1093/nar/gkab882

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab882/6389627
  194. www.sciencedirect.com www.sciencedirect.com
    Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation
    1
    1. scibot 09 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.devcel.2021.09.015

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    sciencedirect.com/science/article/pii/S1534580721007334
  195. Sep 2021
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Corrigendum: Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro
    1
    1. scibot 30 Sep 2021
      plasmid_52961

      DOI: 10.3389/fimmu.2021.763899

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    ncbi.nlm.nih.gov/pmc/articles/PMC8474018/
  197. www.sciencedirect.com www.sciencedirect.com
    SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling
    1
    1. scibot 28 Sep 2021
      Addgene_52961

      DOI: 10.1016/j.stem.2021.09.004

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    sciencedirect.com/science/article/pii/S1934590921003805
  198. www.sciencedirect.com www.sciencedirect.com
    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
    1
    1. scibot 24 Sep 2021
      52961

      DOI: 10.1016/j.molcel.2021.08.039

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    sciencedirect.com/science/article/pii/S1097276521007292
  199. www.sciencedirect.com www.sciencedirect.com
    MultiEditR: The first tool for detection and quantification of multiple RNA editing sites from Sanger sequencing demonstrates comparable fidelity to RNA-seq
    1
    1. scibot 24 Sep 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.omtn.2021.07.008

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    sciencedirect.com/science/article/pii/S2162253121001761
  200. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
    1
    1. scibot 23 Sep 2021
      Addgene_52961

      DOI: 10.1016/j.molcel.2021.08.034

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    sciencedirect.com/science/article/pii/S1097276521007140
  201. www.nature.com www.nature.com
    Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
    1
    1. scibot 16 Sep 2021
      RRID:Addgene_52961

      DOI: 10.1038/s41467-021-25473-y

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    nature.com/articles/s41467-021-25473-y
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZFP36L2 Role in Thyroid Functionality
    1
    1. scibot 14 Sep 2021
      RRID:Addgene_52961

      DOI: 10.3390/ijms22179379

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    ncbi.nlm.nih.gov/pmc/articles/PMC8431063/
  203. www.sciencedirect.com www.sciencedirect.com
    The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
    1
    1. scibot 11 Sep 2021
      Cat# 52961

      DOI: 10.1016/j.cmet.2021.08.012

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    sciencedirect.com/science/article/pii/S1550413121003752
  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition
    1
    1. scibot 04 Sep 2021
      RRID:Addgene_52961

      DOI: 10.3390/cancers13164227

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    ncbi.nlm.nih.gov/pmc/articles/PMC8394935/
  205. jeccr.biomedcentral.com jeccr.biomedcentral.com
    Chemoresistance is mediated by ovarian cancer leader cells in vitro
    1
    1. scibot 03 Sep 2021
      Addgene_52961

      DOI: 10.1186/s13046-021-02086-3

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    jeccr.biomedcentral.com/articles/10.1186/s13046-021-02086-3
  206. Aug 2021
  207. link.springer.com link.springer.com
    Derivation and characterization of an HIV-1 mutant that rescues IP6 binding deficiency
    1
    1. scibot 31 Aug 2021
      RRID:Addgene_52961

      DOI: 10.1186/s12977-021-00571-3

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    link.springer.com/article/10.1186/s12977-021-00571-3
  208. www.sciencedirect.com www.sciencedirect.com
    KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
    1
    1. scibot 31 Aug 2021
      RRID:Addgene_52961

      DOI: 10.1182/bloodadvances.2020002819

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    sciencedirect.com/science/article/pii/S2473952921004171
  209. www.sciencedirect.com www.sciencedirect.com
    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
    1
    1. scibot 25 Aug 2021
      Addgene 52961

      DOI: 10.1016/j.celrep.2021.109596

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    sciencedirect.com/science/article/pii/S2211124721010342
  210. www.sciencedirect.com www.sciencedirect.com
    Establishment of a GFP::LMNB1 knockin cell line (CSUi002-A-1) from a dystonia patient-specific iPSC by CRISPR/Cas9 editing
    1
    1. scibot 19 Aug 2021
      addgene_52961

      DOI: 10.1016/j.scr.2021.102505

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    sciencedirect.com/science/article/pii/S1873506121003524