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  1. Jul 2019
    1. The effect ofthe covariates on survival is to act multiplicatively on some unknown baseline hazardrate, which makes it difficult to model covariate effects that change over time. Secondly,if covariates are deleted from a model or measured with a different level of precision, theproportional hazards assumption is no longer valid. These weaknesses in the Cox modelhave generated interest in alternative models. One such alternative model is Aalen’s(1989) additive model. This model assumes that covariates act in an additive manneron an unknown baseline hazard rate. The unknown risk coefficients are allowed to befunctions of time, so that the effect of a covariate may vary over time.