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  1. Dec 2022
  2. bio.libretexts.org bio.libretexts.org
    11.2: Protein Trafficking
    2
    1. owendavies 04 Dec 2022
      nuclear pore complex.

      Nuclear pore complex or NPC. There is a size exclusion. <60kDa to pass through unassisted.

      BL2301 Protein trafficking Nucleocytoplasmic transport
    2. owendavies 02 Dec 2022
      The SRP is a G-protein and exchanges its bound GDP for a GTP upon binding to a protein’s signal sequence.

      As soon as this sequence is translated, the SRP binds it. Elongation is temporarily arrested. SRP-ribosome complex binds to the SRP receptor on the ER membrane. Translation now continues into the lumen of the ER. The SPR and its receptor are recycled.

      BL2301 Protein trafficking
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    bio.libretexts.org/Bookshelves/Cell_and_Molecular_Biology/Book:_Cells_-_Molecules_and_Mechanisms_(Wong)/11:_Protein_Modification_and_Trafficking/11.02:_Protein_Trafficking
  3. bio.libretexts.org bio.libretexts.org
    17.8: Synthesis of Integral Membrane Proteins
    1
    1. owendavies 02 Dec 2022
      a stop-transfer sequence (a hydrophobic domain within the polypeptide chain) traps the protein in the fatty acid interior
      BL2301 Integral membrane proteins Protein trafficking
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    bio.libretexts.org/Under_Construction/Cell_and_Molecular_Biology_(Bergtrom)/17:_Membrane_Function/17.08:_Synthesis_of_Integral_Membrane_Proteins