Thus, thechallenges mentioned emphasize the necessity of new delivery systems and formulationstrategies
all of these clinical issues connect to issues w/ traditional drug development
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pdfs.semanticscholar.org pdfs.semanticscholar.org
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Consequently, additional modifications (e.g., cyclization, DAAs) are oftenrequired, making the screening process more time-consuming and the manufacturingprocess more costly and complex
Yeah, I remember this. takes so mych longer than you would intitially expect
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ESKAPE pathogens
Didn't know about C.auris that was new info to me
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Antimicrobial resistance (AMR)
Using AI to combat it is so cool!
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From a biochemical perspective, the plasma membrane controlsfluidity, permeability and possesses the ability to respond to stress
basic membrane functions
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In the case of biofilms, QS is important for biofilm formation andcommunication or coordination within the biofilm
QS can dictate which EPS components are excreted and what gene expression is up/down regulated to maintain biofilm
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Another mechanism of resistance against AMPs is biofilm formation, which is acommon virulence factor from ESKAPE pathogens
biofilms would prevent AMPs from accessing the membrane
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- Sep 2026
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pdfs.semanticscholar.org pdfs.semanticscholar.org
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antimicrobialactivity emerges not only from amino acid composition but also from structural elementssuch as secondary structure, amphipathicity, solvent accessibility and conformational stabil-ity
a variety of interacting factors impact antimicrobial capabilities
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toxicity toward mammalian cells, poor serum stability, limited bioavailability
familiar/can explain this in the context of traditional drug development; translational barriers are significanrt
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